Stem　cell　therapy　has　emerged　as　a　promising　approach　for　treating　various　retinal　diseases,　particularly　degenerative　retinal　diseases　such　as　geographic　atrophy　in　age-related　macular　degeneration　(AMD),　retinitis　pigmentosa　(RP),　and　Stargardt　disease.　A　wide　variety　of　imaging　techniques　have　been　employed　in　both　preclinical　and　clinical　settings　to　assess　the　efficacy　and　safety　of　stem　cell　therapy　for　retinal　diseases.　These　techniques　can　be　classified　into　two　categories:　methods　for　imaging　stem　cells　and　those　for　the　overall　morphology　and　function　of　the　retina.　The　techniques　employed　for　stem　cell　imaging　include　optical　imaging,　magnetic　resonance　imaging　(MRI),　and　radionuclide　imaging.　Additional　imaging　techniques　include　fundus　photography,　fluorescein　angiography,　and　fundus　autofluorescence.　Each　technique　has　its　own　advantages　and　disadvantages,　and　thus,　the　use　of　multimodal　imaging　can　help　to　overcome　the　shortcomings　and　achieve　a　more　comprehensive　evaluation　of　stem　cell　therapy　in　retinal　disease.　This　review　discusses　the　characteristics　of　the　main　techniques　and　cell-labeling　techniques　applied　in　stem　cell　therapy,　with　a　particular　focus　on　the　applications　of　multimodal　imaging.　Furthermore,　this　review　discusses　the　challenges　and　prospects　of　multimodal　imaging　in　stem　cell　therapy　for　retinal　disease.　©　2025　by　the　authors.