Graphene　exhibits　excellent　shielding　and　impermeability,　making　it　a　superior　filler　for　promising　anticorrosion　applications.　However,　unmodified　graphene　tends　to　aggregate,　leading　to　structural　defects　and　accelerated　electrochemical　corrosion　of　coatings.　In　this　study,　tetraphenylethene-poly(N-isopropylacrylamide)　was　developed　by　grafting　poly(N-isopropylacrylamide)　onto　tetraphenylethene　for　use　as　an　exfoliation　agent　and　modifier.　Low-defect　modified　graphene　(TPG),　comprising　2–3　layers　of　graphene　flakes　with　excellent　dispersion　stability,　was　efficiently　synthesized　via　microfluidization　process.　To　prevent　the　electrochemical　corrosion　of　coatings,　a　nacre-like　bio-inspired　graphene　coating　(B-TPG/EP)　with　alternating　layers　of　epoxy　resin　(EP)　and　TPG/EP　was　designed　and　prepared　using　a　spin-coating　method.　The　results　showed　that　after　immersion　in　a　3.5　wt%　NaCl　solution　for　42　days,　the　impedance　value　of　B-TPG1%/EP　composite　coating　remained　at　1.04　×　1011　Ω　cm2,　which　is　two　orders　of　magnitude　higher　than　that　of　the　TPG1%/EP　composite　coating　and　eight　orders　of　magnitude　higher　than　that　of　the　EP　coating,　demonstrating　excellent　anti-corrosion　performance.　This　study　demonstrates　a　novel　method　for　graphene　modification,　which　is　characterized　by　its　simplicity　and　high　efficiency　in　the　preparation　process.　Simultaneously,　inspired　by　biological　principles,　it　develops　a　durable　anti-corrosion　coating　for　metals,　which　carries　significant　potential　for　industrial　applications.　©　2025