Colon　cancer,　characterized　by　its　high　incidence　and　mortality　rates,　continues　to　present　a　significant　challenge　in　cancer　treatment.　To　address　this,　we　present　a　novel　ZnCe　based　nanocarrier　featuring　stacked　mesopores　and　rough　surface,　indocyanine　Green　(ICG)　is　encapsulated　within　these　mesopores　(ZnCe&ICG).　This　innovative　nanoplatform　demonstrates　effective　accumulation　in　tumor　regions　and　can　be　triggered　to　generate　efficacious　reactive　oxygen　species　(ROS)　in　the　weakly　acidic　and　high　H2O2　conditions　typical　of　tumor　microenvironments.　Enhanced　fluorescent　imaging　using　improved　tumor-to-background　ratio　has　proven　effective　in　precisely　delineating　tumor　margins　from　surrounding　healthy　tissue.　With　the　guidance　of　this　second　near-infrared　region　(NIR　II,　1000–1700　nm)　fluorescence　imaging　technique,　tumors　are　completely　excised,　resulting　in　negligible　instances　of　in　situ　recurrence　or　metastasis　observed　30　days　following　surgery.　Notably,　under　808　nm　laser　irradiation,　the　nanoplatform　exhibits　a　high　photothermal　conversion　efficiency,　leading　to　localized　heating　that　further　amplifies　ROS　production　via　multi　ion　synergetic　catalysis　for　tumor　cell　killing.　These　results　underscore　the　potential　of　tumor　microenvironment-responsive　ZnCe-based　nanocomposite　as　a　fluorescence　imaging　contrast　agent　and　chemodynamic　agent　for　cancer　treatment,　particularly　when　combined　with　NIR　light　activation.　©　2025　Elsevier　Inc.