This　work　underscores　the　critical　importance　of　enhancing　the　mass　transfer　performance　of　catalyst　particles　for　the　production　of　n-butyl　levulinate　(BL)　from　levulinic　acid　(LA).　The　lattice　Boltzmann　method　was　proposed　to　investigate　the　relationship　between　pore　structure　and　mass　transfer,　thereby　guiding　the　rational　design　of　high-performance　catalyst.　Furthermore,　a　novel　catalyst　regulation　strategy　was　introduced,　utilizing　UiO-66　as　a　template　to　fabricate　a　series　of　catalysts,　UiOxD40H160-SO3H.　This　strategy　allows　for　the　regulation　of　the　pore　structure　of　resin　catalysts　over　a　broader　range　and　successfully　enhanced　the　mass　transfer　performance.　Among　the　synthesized　catalysts,　the　LA　conversion　efficiency　with　UiO0.4D40H160-SO3H　under　mild　reaction　conditions　increased　by　an　average　of　18.1%　compared　to　the　previously　reported　best-performing　Dowex　50Wx2　resin　catalyst.　These　findings　provide　valuable　new　insights　into　the　production　of　BL　while　also　highlighting　the　potential　of　the　proposed　catalyst　design　strategy　for　industrial　applications.