This　study　aimed　to　investigate　the　predictive　effect　of　static　lung　compliance　(SLC)　and　airway　resistance　(AR)　in　patients　undergoing　minimally　invasive　cardiac　surgery　(MICS)　with　unilateral　pulmonary　edema　(UPE).　A　total　of　245　patients　who　underwent　MICS　via　cardiopulmonary　bypass　and　minimal　right　lateral　thoracic　incision　port　access　were　enrolled,　with　immediate　postoperative　SLC　and　AR　data　collected　upon　intensive　care　unit　(ICU)　admission.　Cutoff　values　for　grouping　patients　into　high　(H-)　and　low　(L-)　compliance/resistance　categories　were　determined　using　receiver-operating　characteristic　curves　and　Youden　indexes.　The　primary　outcome　was　the　incidence　of　radiographically　and　clinically　defined　UPE　within　the　first　24　hours　postoperatively,　while　the　secondary　outcomes　included　duration　of　mechanical　ventilation,　length　of　ICU　stay,　total　hospitalization　days,　in-hospital　mortality,　and　the　highest　sequential　organ　failure　assessment　(SOFA)　and　acute　physiology　and　chronic　health　evaluation　II　(APACHE-II)　scores　within　the　first　24　hours　post-surgery.　Results　showed　that　patients　in　the　L-compliance　group　(SLC　＜　40　mL/cmH2O)　had　longer　durations　of　mechanical　ventilation,　length　of　ICU　stay,　and　total　hospitalization　days,　along　with　higher　SOFA　and　APACHE-II　scores　compared　to　those　in　the　H-compliance　group　(SLC　＞=　40　mL/cmH2O)　(P　＜.05),　although　there　was　no　significant　difference　in　in-hospital　mortality.　Conversely,　patients　in　the　H-resistance　group　(AR　＞=　11　cm　H2O/[L.s])　exhibited　longer　durations　of　mechanical　ventilation,　length　of　ICU　stay,　and　total　hospitalization　days,　as　well　as　significantly　higher　SOFA,　APACHE-II　scores,　but　lower　in-hospital　mortality　rates　than　those　in　the　L-resistance　group　(AR　＜　11　cm　H2O/[L.s])　(P　＜.05).　In　summary,　immediate　postoperative　SLC　＜　40　mL/cm　H2O　and　AR　＞　11　cm　H2O/(L.s)　are　potentially　valuable　indicators　for　predicting　postoperative　UPE　in　patients　undergoing　MICS.