Deep　eutectic　polymer　electrolytes　(DEPEs)　have　emerged　as　highly　promising　next-generation　electrolytes,　offering　unparalleled　electrochemical　performance　and　safety.　Their　excellence　stems　from　a　synergistic　blend　of　the　robust　mechanical　stability　of　solid　polymer　electrolytes　and　the　exceptional　interfacial　wettability　and　superior　thermal　resilience　of　deep　eutectic　electrolytes.　However,　conventional　DEPEs　frequently　exhibit　suboptimal　Li+　conductivity　due　to　strong　coordination　between　Li+　and　oxygen-containing　polymer　moieties.　Inspired　by　the　concept　of　＇gene-editing＇　in　biology,　we　propose　a　novel　deep　eutectic　polymer　electrolyte　(GEPE)　with　precisely　tailored　molecular　architectures　This　approach　exploits　the　steric　hindrance　and　electron-withdrawing　inductive　effects　from　isophorone　diisocyanate-derived　segments　to　reduce　Li+-polymer　interactions,　thereby　enabling　an　extraordinary　ionic　conductivity　of　3.00　mS　cm(-)(1)　at　25　degrees　C　and　a　Li+　transference　number　of　0.61.　Remarkably,　GEPE　exhibits　extraordinary　cycling　stability　in　Li||Li　symmetric　cells　for　over　3000　h,　demonstrating　dendrite-free　Li　metal　deposition　during　prolonged　cycling.　Moreover,　the　assembled　lithium　metal　batteries　demonstrate　exceptional　electrochemical　performance　when　incorporating　diverse　cathodes,　including　LiNi0.5Co0.2Mn0.3O2,　LiNi0.8Co0.1Mn0.1O2,　and　LiFePO4.　Notably,　the　Li|GEPE|LiFePO4　cells　achieve　an　impressive　nearly　100%　Coulombic　efficiency　and　remarkable　long-term　stability　over　10　000　cycles　at　5C.