The　dissolution　of　complex　silicate　minerals　has　a　significant　influence　on　the　flotation　of　quartz,　but　its　effect　and　mechanism　have　not　been　clarified.　In　this　work,　the　inhibition　effect　and　mechanism　of　actinolite　on　quartz　flotation　using　dodecylamine　(DDA)　as　a　collector　were　investigated　via　micro-flotation,　mineral　dissolution,　adsorption　tests,　wrapping　angle　tests,　Atomic　Force　Microscope　(AFM)　measurement,　Fourier　Transform　Infrared　Spectroscopy　(FTIR),　zeta　potential　characterization,　contact　angle　tests,　X-ray　Photoelectron　Spectroscopy　(XPS)　analyses,　and　solution　chemistry　calculation.　Micro-flotation　tests　showed　that　actinolite　adversely　affected　the　flotation　of　quartz　and　the　unfavorable　effect　increases　with　decreasing　particle　size　and　increasing　content.　The　results　of　the　surface　analysis　showed　that　the　dissolved　metal　ions　(i.e.,　Ca2+,　Mg2+,　and　Fe3+)　from　actinolite　can　be　adsorbed　on　the　quartz　surface,　hindering　the　adsorption　of　DDA　on　the　quartz　surface,　reducing　the　hydrophobicity　of　the　quartz　surface,　and　thus　decreasing　the　recovery　of　quartz.　In　addition,　in　the　system　of　actinolite-quartz,　the　adsorption　of　DDA　on　actinolite　and　quartz　is　competitive,　and　the　adsorption　of　more　DDA　on　the　surface　of　actinolite,　which　has　a　larger　specific　surface　area,　will　weaken　the　adsorption　of　DDA　on　the　surface　of　quartz　and　hinder　the　attachment　of　quartz　particles　on　the　surface　of　bubbles,　thus　inhibiting　the　flotation　of　quartz.　In　summary,　the　inhibition　of　quartz　flotation　by　actinolite　arises　from　a　combination　of　metal　ions　dissolved　in　actinolite　adsorbed　on　the　quartz　surface　and　competition　between　actinolite　and　quartz　for　adsorbed　DDA.