Background:　Bacterial　skin　diseases　(BSDs)　represent　a　substantial　public　health　concern　for　children　and　adolescents　worldwide.　The　emergence　of　community-associated　methicillin-resistant　Staphylococcus　aureus　(CA-MRSA)　has　further　complicated　treatment,　efforts,　highlighting　the　urgent　need　for　targeted　policies　aimed　at　prevention　and　management.　Methods:　This　study　utilized　data　from　the　Global　Burden　of　Disease　(GBD)　2021　database,　to　analyze　the　global　burden　of　BSDs　among　individuals　aged　0–19　years　from　1990　to　2021.　Incidence,　prevalence,　and　disability-adjusted　life　years　(DALYs)　were　the　primary　indicators　assessed.　stratified　analysis　conducted　by　gender,　age,　region,　and　socio-demographic　index　(SDI).　Temporal　trends　were　evaluated　using　the　estimated　annual　percentage　change　(EAPC).　Date　analysis　and　visualization　were　performed　using　the　R　programming　language.　Results:　In　2021,　the　global　incidence　of　BSDs　among　children　and　adolescents　reached　338 million　cases,　an　increase　of　49.32%　compared　to　1990　(EAPC　=　0.86);　Prevalence　reached　14.23 million　cases,　an　increase　of　48.27%　(EAPC　=　0.85).　During　the　same　period,　the　DALYs　rate　decreased　by　39.01%　(EAPC　=　-1.9).　Regionally,　the　burden　was　highest　in　sub-Saharan　Africa,　while　the　highest　increase　in　incidence　was　observed　in　high-income　North　America.　SDI-based　stratification　showed　that　DALYs　were　highest　among　infants　in　low　SDI　regions,　while　high　SDI　regions　experienced　a　marked　increase　in　incidence　among　adolescents　aged　15–19　years.　Gender　analysis　found　that　the　incidence　was　higher　among　girls　under　five　years　of　age,　while　the　overall　burden　was　higher　among　boys　aged　15–19　years　compared　to　girls.　Neonates　(0–6　days)　were　identified　as　the　highest-risk　group.　Conclusion:　Although　a　moderate　decline　in　DALYs　rate　was　observed,　the　incidence　and　prevalence　of　BSDs　continued　to　rise　globally,　with　geographic,　age-related,　and　genders　disparities.　These　findings　underscore　the　necessity　of　developing　stratified　and　targeted　intervention　strategies　to　mitigate　the　increasing　burden　of　BSDs　among　children　and　adolescents.　©　The　Author(s)　2025.