Optical　instruments,　electronic　products,　and　medical　fields　urgently　require　the　development　of　robust　and　transparent　anti-fouling　coatings.　However,　traditional　coatings　often　struggle　to　balance　mechanical　properties　with　anti-fouling　performance　and　may　contain　components　that　are　detrimental　to　the　environment.　A　high　cross-linking　density　design　helps　to　enhance　the　mechanical　properties　and　corrosion　resistance　of　coatings　without　the　use　of　environmentally　unfriendly　components.　In　this　work,　we　prepared　a　novel　polyhedral　oligomeric　silsesquioxane　(POSS)　material　with　multiple　epoxy　groups,　EP-POSS,　through　a　click　reaction.　We　selected　an　appropriate　multi-point　amine　curing　agent,　tetraethylenepentamine,　leveraging　its　efficient　curing　with　EP-POSS　to　construct　a　multi-point,　highly　cross-linked　network.　This　process　not　only　strengthens　the　mechanical　strength　and　chemical　resistance　of　the　coating　but　is　also　simple　and　cost-effective.　Environmentally　friendly　polydimethylsiloxane　is　used　to　provide　flexibility　and　liquid　repellency.　The　final　EPOSSPT　coating　boasts　high　transparency　(＞　99　%),　low　surface　roughness　(arithmetic　mean　deviation　(Sa):　∼0.515　nm),　and　excellent　repulsion　to　both　liquid　and　solid　contaminants,　demonstrating　superior　self-cleaning　and　anti-fouling　properties.　It　achieves　a　balance　between　high　hardness　(7H)　and　excellent　flexibility　(7500　bending　cycles　with　a　bending　radius　of　1　mm),　while　also　resisting　wear　and　impact　from　everyday　use.　This　high-transparency,　robust,　and　flexible　coating　has　broad　application　prospects　and　offers　insights　into　the　design　of　new　high-performance　protective　materials.　©　2025