The　innate　immunity　helps　the　individuals　in　the　exposed　compartment　return　into　the　ones　in　the　susceptible　compartment　when　a　pathogen　or　virus　invades　the　local　population　of　having　four　compartments:　the　susceptible,　the　exposed,　the　infected　and　the　recovered.　In　this　study,　we　propose　a　stochastic　SEIR　model　with　innate　immunity　and　treatment.　Here,　Holling　type　II　functional　responses　are　used　to　describe　the　saturated　effects　of　the　innate　immunity　and　treatment.　Then,　we　obtain　the　extinction　of　the　exposed　and　the　infected　when　the　basic　reproduction　number　R0　＜　1　and　the　exponential　decline　rate　ν　＜　0　are　valid.　Moreover,　we　conclude　that　when　innate　immunity　and　treatment　increase,　the　time　that　the　exposed　and　the　infected　approach　zero　reduces.　We　also　find　that　the　deterministic　SEIR　model　reaches　extinction　a　bit　faster　than　the　stochastic　SEIR　model.　Further,　the　persistence　in　the　mean　and　stationary　distribution　of　stochastic　SEIR　model　are　obtained　under　suitable　conditions.　Finally,　the　numerical　investigations　with　two　methods　and　a　case　study　of　Fuzhou　COVID-19　epidemic　of　2022　are　discussed.　©　2025,　Wilmington　Scientific　Publisher.　All　rights　reserved.