Ethyl　acetate　(EA)　is　a　stable　oxygenated　volatile　organic　compound　(VOC)　that　is　challenging　to　fully　degrade　due　to　its　strong　chemical　bonds.　High-entropy　metal　oxides　(HEOs)　with　their　active　lattice　oxygens　and　diverse　metal–oxygen　bonds　hold　great　potential　for　efficient　degradation　of　EA.　However,　synthesizing　HEOs　without　phase　separation　remains　a　significant　challenge.　In　this　study,　we　developed　an　electrospinning　method　to　synthesize　spinel-type　high-entropy　(CoMnNiFeZn)Ox　catalysts,　achieving　90%　EA　conversion　at　266　°C　with　a　CO2　selectivity　of　100%.　The　catalyst　demonstrated　a　high　turnover　frequency　of　101.5　±　0.8　h−1　based　on　the　total　metal　content.　The　optimal　1　mmol-HEO　catalyst　demonstrated　excellent　stability　in　both　five-cycle　and　thermal　stability　tests.　An　18O　isotope-labelled　experiment　confirmed　that　the　oxidation　of　EA　follows　the　Marsvan-Krevelen　mechanism,　with　high　lattice　oxygen　mobility　significantly　enhancing　catalytic　activity.　Furthermore,　in　situ　diffuse　reflectance　infrared　Fourier　transform　spectroscopy　provided　insights　into　the　roles　of　different　metal–oxygen　bonds　in　the　catalytic　mechanism.　This　work　deepens　the　understanding　of　metal–oxygen　bond　interactions　in　the　oxidation　of　oxygenated　VOCs　and　offers　a　viable　approach　for　synthesizing　HEOs.　(Figure　presented.)　©　Science　China　Press　2025.