Objectives:　Few　studies　have　provided　a　detailed　analysis　of　stress　distribution　on　the　components　of　multi-unit　abutment　(MUA)-implants　complex,　particularly　the　abutment　screw　and　prosthetic　screw,　which　are　among　the　most　fragile　parts　of　the　restoration.　Our　objective　was　to　investigate　the　differences　of　stress　distribution　on　the　components　of　MUA-implants　complex　under　varies　loading　conditions　using　finite　element　analysis.　Materials　and　methods:　We　constructed　MUA-implant　complexes　with　different　abutment　angulations　(0°,　17°,　and　30°).　A　static　force　of　200 N　was　applied　along　the　axis　of　the　prosthetic　abutment,　accompanied　by　varying　lateral　forces　(0 N,　30 N,　and　100 N).　Results:　When　subjected　to　a　200 N　axial　load,　implants　with　a　30°　angulated　abutment　experienced　nearly　2.5　times　the　stress　(1185 MPa)　compared　to　straight　abutments　(437 MPa).　The　maximum　stress　of　the　straight　MUA-implant　was　8　times　higher　under　a　100 N　lateral　force　(2389 MPa)　compared　to　that　without　lateral　force.　Prosthetic　screws　suffered　higher　stress　concentration　than　the　abutment　screw　and　stress　was　mostly　located　near　the　first　thread　of　the　prosthetic　screw.　Conclusions:　There　is　a　distinct　stress　distribution　pattern　between　the　prosthetic　screw　and　abutment　screw,　with　the　former　experiencing　higher　stress　concentration　than　the　latter.　Clinical　relevance:　The　present　study　indicates　that　prosthetic　screws　are　more　vulnerable　to　mechanical　complications　and　cautions　should　be　raised　to　balance　biting　force　to　minimize　the　risks　of　mechanical　complications　in　patients　with　angulated　MUA-implants　complex.　©　The　Author(s),　under　exclusive　licence　to　Springer-Verlag　GmbH　Germany,　part　of　Springer　Nature　2025.