Janus　hydrogels,　distinguished　by　their　dual-sided　structure　with　distinct　physical　and　chemical　properties,　have　garnered　significant　attention　in　the　medical　field,　particularly　for　applications　in　drug　delivery,　tissue　engineering,　and　wound　healing.　Their　ability　to　simultaneously　perform　multiple　functions,　such　as　targeted　drug　release　and　biomimetic　tissue　interaction,　positions　them　as　a　promising　platform　for　advanced　therapeutic　strategies.　The　growing　interest　in　these　hydrogels　is　primarily　driven　by　their　multifunctionality　and　capacity　to　address　complex　biological　needs.　This　review　delves　into　the　design,　fabrication　methods,　and　applications　of　Janus　hydrogels　in　medicine,　focusing　on　their　potential　to　overcome　the　limitations　of　conventional　therapies　and　providing　a　comprehensive　overview　of　their　role　in　contemporary　biomedical　applications.　©　2025　by　the　authors.