Fluoride　pollution　is　a　serious　environmental　problem　that　is　a　risk　to　human　health.　Hence,　the　effective　elimination　of　fluoride　is　urgent.　Herein,　a　novel　trimetallic　Zr-La-Ce　MOF　was　fabricated　with　a　hydrothermal　method　and　adapted　to　eliminate　fluoride　from　water　media.　Characterization　showed　that　the　adsorbent　presented　a　flower-like　morphological　structure　with　a　large　specific　surface　area　of　682　m2　g-1.　The　adsorption　property　was　further　evaluated　by　examining　the　impact　of　fluoride　concentration,　solution　pH,　and　coexisting　anions.　The　adsorption　capacity　of　Zr-La-Ce　MOFs　is　above　110　mg　g-1　at　pH　2-9,　indicating　that　Zr-La-Ce　MOFs　have　a　wide　applied　pH　range,　and　the　coexisting　ions　have　a　tiny　impact　on　the　fluoride　removal　performance,　demonstrating　an　excellent　fluoride　selectivity.　The　sorption　process　adhered　well　to　the　Langmuir　model　and　pseudo-second　order　kinetic　model,　and　the　maximum　Langmuir　sorption　capacity　was　167.61　mg　g-1.　Practical　application　investigation,　regeneration　performance　evaluation,　and　safety　experiments　demonstrated　that　the　Zr-La-Ce　MOFs　had　excellent　recycling　performance,　with　the　treated　water　lower　than　1　mg　L-1,　and　no　precipitation　of　metal　ions,　which　has　certain　potential　for　practical　application　and　can　provide　insights　and　references　for　the　preparation　of　multimetal　MOFs.　©　2025　American　Chemical　Society.