The　removal　of　water　pollutants　through　adsorption　by　porous　materials　has　been　demonstrated　to　be　an　effective　method　due　to　its　relatively　low　cost,　simple　design,　ease　of　operation,　and　regeneration　capabilities.　In　this　study,　we　assembled　three　robust　porous　organic　cages　(POCs),　namely　CPOC-109,　CPOC-110,　and　CPOC-111,　from　the　same　tetraformyl-functionalized　calix[4]resorcinarene　(C4RACHO)　cap　and　three　different　types　of　diamino　linkers,　with　the　number　of　sulfur　atoms　ranging　from　0　to　2.　Single　X-ray　crystallographic　analysis　reveals　that　all　three　CPOCs　exhibit　[2　+　4]　lantern-shaped　structures　with　large　intrinsic　cavities,　having　heights　and　cavity　volumes　ranging　from　1.74　to　1.80　nm　and　1023.42　to　1157.66　Å3,　respectively.　Furthermore,　77　K　N2　gas　adsorption　measurements　suggest　that　all　CPOCs　exhibit　high　porosity,　with　Brunauer-Emmett-Teller　(BET)　specific　surface　areas　reaching　up　to　700　m2　g-1.　Leveraging　their　porous　nature　and　rich　coordination　sites　(N,　O,　and　S),　the　application　of　these　CPOCs　for　the　adsorptive　removal　of　Hg(II)　from　aqueous　solutions　was　explored.　Notably,　CPOC-111　demonstrated　superior　Hg(II)　adsorption　capacity　(220.26　mg/g)　compared　to　CPOC-109　and　CPOC-110.　Additionally,　CPOC-111　exhibited　excellent　cycling　performance　and　maintained　good　adsorption　stability　within　a　broad　pH　range　of　3　to　11.　This　study　serves　as　a　compelling　example　of　using　POC　adsorbents　for　the　removal　of　Hg(II)　ions　from　water　and　highlights　the　potential　for　expanding　the　application　of　POC　materials　in　environmental　remediation　and　pollution　control.　©　2025　American　Chemical　Society.