Cold atmospheric plasma combined with nanoparticles in cancer therapy - Details

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This　review　explores　the　application　of　cold　atmospheric　plasma　(CAP)　and　nanoparticles　(NPs)　in　cancer　therapy,　highlighting　their　potential　to　enhance　treatment　efficacy　and　minimize　side　effects.　CAP　generates　reactive　oxygen　and　nitrogen　species　that　selectively　induce　apoptosis　in　cancer　cells,　while　NPs　improve　drug　delivery,　enhance　targeting　precision,　and　reduce　adverse　effects　on　healthy　tissues.　By　summarizing　various　types　of　NPs,　including　gold,　silver,　magnetic,　and　other　NPs,　we　evaluate　their　individual　and　combined　effects　with　CAP　across　different　cancer　models.　Our　findings　suggest　that　combined　CAP-NPs　significantly　enhance　therapeutic　outcomes　by　increasing　cancer　cell　sensitivity　and　minimizing　damage　to　surrounding　tissues.　This　synergistic　approach　not　only　aligns　with　previous　research　on　CAP＇s　selective　toxicity　but　also　reveals　new　possibilities　for　optimizing　cancer　treatment　through　targeted　NP　delivery.　Further　clinical　research　is　needed　to　establish　the　safety　and　efficacy　of　this　combination,　paving　the　way　for　novel,　patient-specific　treatment　strategies　with　improved　outcomes.　©　2025　The　Author(s).　Interdisciplinary　Medicine　published　by　Wiley-VCH　GmbH　on　behalf　of　Nanfang　Hospital,　Southern　Medical　University.

Keyword：

cancer therapy cold atmospheric plasma nanoparticles reactive nitrogen species reactive oxygen species

Community：

[ 1 ] [Wang Y.]Department of Chemistry, College of Sciences, Northeastern University, Shenyang, China
[ 2 ] [Wang Y.]Paul C Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
[ 3 ] [Cao F.]Paul C Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
[ 4 ] [Martins G.A.]Paul C Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
[ 5 ] [Fang Q.]Paul C Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
[ 6 ] [Fang Q.]Advanced Therapeutic Center, National Innovation Center for Advanced Medical Devices, Shenzhen, China
[ 7 ] [Lin Y.]Division of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong
[ 8 ] [Chen Z.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Institute of Food Safety and Environment Monitoring, College of Chemistry, Fuzhou University, Fuzhou, China
[ 9 ] [Chen G.]Department of Biomedical Engineering, Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada
[ 10 ] [Chen Z.]Paul C Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
[ 11 ] [Chen Z.]Advanced Therapeutic Center, National Innovation Center for Advanced Medical Devices, Shenzhen, China
[ 12 ] [Chen Z.]Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen, China

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Interdisciplinary Medicine

ISSN： 2832-6237

Year： 2025

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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