Fluorinated　compounds　are　scarce　in　nature,　albeit　they　are　in　high　demand　in　pharmaceuticals,　agrochemicals,　and　materials.　Fluorinated　amides　serve　as　prevalent　structural　motifs　in　pharmaceuticals　and　bioactive　molecules.　However,　enantioselective　synthesis　of　fluorinated　amides　remains　challenging.　Herein,　we　develop　a　visible-light-driven　ene-reductase　system　that　effectively　generates　carbon-centered　radicals　from　fluorine-containing　brominated　amides.　The　system　further　enables　their　enantioselective　hydroalkylation　with　alkenes,　achieving　high　stereocontrol.　Diversified　alpha-fluorinated　amides　with　high　yield　(up　to　91%)　and　distal　chirality　(gamma-to　F,　up　to　97%　enantiomeric　excess)　are　produced　by　optimizing　the　reaction　system　and　performing　enzyme　engineering.　This　work　advances　photoenzymatic　strategies　for　the　integration　of　fluorinated　chemical　inputs　and　creates　an　opportunity　for　the　asymmetric　synthesis　of　valuable　fluorinated　compounds.