The　construction　of　multicomponent　transition　metal　oxide　catalysts　can　effectively　increase　the　surface　defects　of　catalysts,　and　bring　a　synergistic　effect　from　different　components,　thus　enhancing　the　generation　of　reactive　oxygen　species　and　improving　the　catalytic　activity　of　catalysts　for　volatile　organic　compounds　(VOCs)　oxidation.　In　this　article,　CuO/Co3O4　catalysts　with　abundant　oxygen　vacancies　for　the　degradation　of　ethyl　acetate　was　prepared　by　a　simple　impregnation　method.　The　effect　of　the　ratio　of　Co/Cu　on　the　redox　capacity,　oxygen　vacancy,　active　oxygen　species　and　catalytic　oxidation　activity　of　ethyl　acetate　were　studied.　The　90%　conversion　and　mineralization　temperatures　of　ethyl　acetate　for　the　optimal　catalyst　Co3O4-20Cu　are　211　and　214　degrees　C　(WHSV　=　60,000　mL/(gh),　1000　ppm　ethyl　acetate),　which　also　shows　good　stability　and　excellent　water　vapor　resistance.　Compared　with　pure　Co3O4,　the　CuO/Co3O4　catalysts　have　more　oxygen　vacancies,　provide　more　reactive　oxygen　species,　allowing　the　catalyst　better　low-temperature　reduction.　Through　in　situ　DRIFTS　study,　the　intermediates　of　ethyl　acetate　decomposition　were　analyzed,　then　a　possible　catalytic　oxidation　mechanism　of　ethyl　acetate　on　the　Co3O4-20Cu　catalyst　was　proposed.　In　addition,　we　prepared　a　Co3O4-20Cu/cordierite　monolithic　catalyst　on　the　basis　of　Co3O4-20Cu,　exhibiting　a　good　catalytic　activity　in　degradation　of　ethyl　acetate.