Mesoporous　bioactive　glasses　(MBGs)　are　gaining　recognition　in　bone　tissue　engineering　for　their　osteoblast　differentiation-inducing　properties　and　customizable　structures.　However,　the　challenge　of　peri-implantitis　has　hindered　their　broader　application.　To　address　this,　double　transition　metal　TiNbCTx　MXene　acted　as　near-infrared　(NIR)　photothermal　agent,　has　been　integrated　with　MBG　nanospheres　to　develop　novel　multifunctional　TiNbCTx/MBG　(TNC/MBG)　nanocomposites　in　this　work.　The　results　demonstrate　that　the　TNC/MBG　composites　feature　uniform　mesoporous　spherical　MBG　nanoparticles　on　TiNbCTx　nanosheets,　boasting　a　significantly　enhanced　specific　surface　area　of　up　to　444.74　m2 g−1　and　a　more　negative　zeta　potential　than　pristine　MBG.　Importantly,　the　TNC/MBG　nanocomposites　can　effectively　promote　apatite　formation,　as　well　as　the　proliferation　and　viability　of　MC3T3-E1　cells.　Moreover,　it　is　highlighted　that　the　TNC/MBG　nanocomposites　display　remarkable　photothermal　conversion　efficiency　and　stability,　leading　to　over　95%　antibacterial　inhibition　rates　against　both　S.　aureus　and　E.　coli　under　NIR　irradiation.　These　findings　offer　an　appealing　strategy　to　develop　multifunctional　TNC/MBG　nanocomposites　with　enhanced　biological　activity　and　robust　antibacterial　properties,　which　shows　great　potential　for　various　biomedical　applications.　©　2025　Wiley-VCH　GmbH.