Bacterial　infections　pose　an　increasing　threat　to　human　health.　Chemodynamic　therapy　(CDT),　which　utilizes　nanozymes　to　catalyze　H2O2　into　highly　toxic　hydroxyl　radicals　(·OH),　offers　a　promising　disinfection　strategy　because　of　its　high　efficacy,　broad-spectrum　antibacterial　activity,　and　low　risk　of　inducing　drug　resistance.　Herein,　we　developed　a　self-powered　CDT　nanocomposite,　CaO2@PCN-222(Fe),　via　a　facile　one-pot　synthesis　for　wound　disinfection.　In　infected　wounds,　the　CaO2　component　of　the　composite　gradually　hydrolyzes　to　H2O2,　while　the　PCN-222(Fe)　component　acts　as　peroxidase　mimics　to　efficiently　catalyze　the　generated　H2O2　into　·OH,　thus　achieving　self-powered　CDT.　In　vitro　assays　confirmed　that　the　minimum　bactericidal　concentration　of　the　composite　against　Staphylococcus　aureus　is　as　low　as　31.25　μg　mL-1.　Furthermore,　in　vivo　assays　demonstrated　that　the　composite　could　effectively　accelerate　infected　wound　healing.　To　broaden　application　scenarios,　the　composite　was　further　integrated　into　poly(vinylidene　fluoride)　(PVDF)　to　form　CaO2@PCN-222(Fe)@PVDF　mixed　matrix　membranes　(MMMs),　which　inherit　the　self-powered　CDT　capability,　exhibiting　high　antimicrobial　activity　and　promoting　infected　wound　healing.　Notably,　no　significant　toxicity　was　observed　for　CaO2@PCN-222(Fe)　and　its　MMMs.　This　work　presents　an　efficient　self-powered　CDT　modality,　combining　the　advantages　of　CaO2　and　peroxidase　mimics　for　treating　bacterial　infections　and　promoting　infected　wound　healing.　©　2025　American　Chemical　Society.