Marine　biodiversity　is　of　critical　importance　to　global　ecosystems.　The　Indo-Pacific　Convergence　Zone　(IPCZ),　a　global　marine　biodiversity　hotspot,　faces　escalating　threats　from　human　activities　and　climate　change.　This　underscores　the　pressing　need　to　develop　effective　conservation　strategies　for　marine　biodiversity　in　the　IPCZ.　This　study　integrates　spatial　analysis　of　ecological　sensitivity　(coral　reefs,　mangroves,　and　seagrass)　and　anthropogenic　pressures　(shipping/fishing　intensity)　to　identify　biodiversity　hotspots　and　conservation　gaps.　Using　datasets　from　UNEP-WCMC,　OBIS,　and　Global　Fishing　Watch,　we　applied　GIS-based　multi-criteria　evaluation　to　5408　grid　cells　(0.5°　resolution)　across　the　IPCZ.　Results　revealed　that　14.7%　of　the　study　area　constitutes　biodiversity　hotspots,　primarily　in　coastal　Philippines,　Indonesia’s　Lesser　Sunda　Islands,　and　northern　Australia.　However,　only　6%　of　the　IPCZ　is　currently　protected,　with　merely　13.88%　of　hotspots　overlapping　existing　marine　protected　areas　(MPAs).　Anthropogenic　pressure　hotspots　(e.g.,　Malacca　Strait)　showed　limited　spatial　overlap　with　biodiversity　hotspots,　suggesting　species　displacement　from　high-disturbance　zones.　Priority　conservation　areas　were　delineated　by　balancing　ecological　significance　and　economic　activity　conflicts.　We　propose　targeted　strategies,　including　buffer　zones,　seasonal　no-take　areas,　and　green　shipping　technologies,　to　reconcile　conservation　with　sustainable　development.　This　framework　provides　actionable　insights　for　enhancing　MPA　networks　in　biogeographic　transition　zones.　©　2025　by　the　authors.