Finding　an　optimal　isolator　arrangement　for　asymmetric　structures　using　traditional　conceptual　design　methods　that　can　significantly　minimize　torsional　response　while　ensuring　efficient　horizontal　seismic　isolation　is　cumbersome　and　inefficient.　Thus,　this　work　develops　a　multi-objective　optimization　method　to　enhance　the　torsional　resistance　of　asymmetric　base-isolated　structures.　The　primary　objective　is　to　simultaneously　minimize　the　interstory　rotation　of　the　superstructure,　the　rotation　of　the　isolation　layer,　and　the　interstory　displacement　of　the　superstructure　without　exceeding　the　isolator　displacement　limits.　A　fast　non-dominated　sorting　genetic　algorithm　(NSGA-II)　is　employed　to　satisfy　this　optimization　objective.　Subsequently,　the　isolator　arrangement,　encompassing　both　positions　and　categories,　is　optimized　according　to　this　multi-objective　optimization　method.　Additionally,　an　optimization　design　platform　is　developed　to　streamline　the　design　operation.　This　platform　integrates　the　input　of　optimization　parameters,　the　output　of　optimization　results,　the　finite　element　analysis,　and　the　multi-objective　optimization　method　proposed　herein.　Finally,　the　application　of　this　multi-objective　optimization　method　and　its　associated　platform　are　demonstrated　on　two　asymmetric　base-isolated　structures　of　varying　heights　and　plan　configurations.　The　results　indicate　that　the　optimal　isolator　arrangement　derived　from　the　optimization　method　can　further　improve　the　control　over　the　lateral　and　torsional　responses　of　asymmetric　base-isolated　structures　compared　to　conventional　conceptual　design　methods.　Notably,　the　interstory　rotation　of　the　optimal　base-isolated　structure　is　significantly　reduced,　constituting　only　approximately　33.7%　of　that　observed　in　the　original　base-isolated　structure.　The　proposed　platform　facilitates　the　automatic　generation　of　the　optimal　design　scheme　for　the　isolators　of　asymmetric　base-isolated　structures,　offering　valuable　insights　and　guidance　for　the　burgeoning　field　of　intelligent　civil　engineering　design.　©　Institute　of　Engineering　Mechanics,　China　Earthquake　Administration　2025.