Glioma,　marked　by　high　incidence　and　mortality,　remains　a　major　challenge　in　cancer　therapy.　Traditional　therapies　based　on　reactive　oxygen　species　(ROS)　encounter　significant　limitations,　particularly　due　to　their　low　catalytic　efficiency,　which　hinders　their　broader　use.　To　overcome　this,　we　introduce　a　novel　NiCe-based　nanocarrier　featuring　stacked　mesopores　and　a　rough　surface.　Indocyanine　green　(ICG)　is　encapsulated　within　the　mesopores　(NiCe@I),　and　cyclo(RGDfK)　peptides　(RGD)　are　conjugated　on　the　surface　(NiCe@IG).　This　advanced　nanoplatform　exhibits　efficient　and　targeted　accumulation　at　tumor　sites　and　is　designed　to　generate　potent　ROS　in　the　tumor　microenvironment,　characterized　by　weak　acidity　and　elevated　H2O2　levels.　Under　808　nm　laser　irradiation,　the　nanoplatform　demonstrates　high　photothermal　conversion　efficiency,　inducing　localized　heating　that　enhances　ROS　production　through　multi-ion　synergistic　catalysis,　leading　to　effective　tumor　cell　destruction.　These　findings　highlight　the　potential　of　the　NiCe-based　nanocomposite　as　a　tumor　microenvironment-responsive　contrast　agent　for　fluorescence　imaging　and　a　chemodynamic　agent　for　cancer　therapy,　particularly　when　activated　by　NIR　light.　©　2025　The　Authors