For　traditional　strategies　to　construct　SO2　and　H2O　co-resistant　systems　in　low-temperature　NH3　selective　catalytic　reduction　(NH3-SCR)　catalysts,　the　primary　challenge　lies　in　mitigating　the　partial　loss　of　redox　activity　at　active　sites.　Herein,　we　present　an　approach　to　construct　a　protective　system　based　on　interface　engineering　principles,　effectively　safeguarding　Cu　active　sites　in　ZnO/FeCu-SSZ-13　under　SO2　and　H2O　exposure.　The　core　innovation　stems　from　the　creation　of　a　strong　interface　effect　originated　from　Zn-O-Al　bonds　formed　between　ZnO　and　the　framework　Al　on　the　FeCu-SSZ-13　surface.　This　interface　effect　can　regulate　the　electronic　structure　of　Zn[sbnd]O　bonds　on　ZnO　component,　producing　abundant　basic　sites　around　the　Cu　active　sites,　enabling　the　preferential　adsorption　of　SO2　and　its　oxidation　into　ZnSO4,　thereby　virtually　eliminating　the　redox　ability　loss　of　Cu　active　sites.　As　a　result,　ZnO/FeCu-SSZ-13　achieves　exceptional　low-temperature　NH3-SCR　performance,　maintaining　over　90　%　NOx　conversion　even　in　the　presence　of　SO2　and　H2O.　Our　work　opens　a　new　avenue　for　developing　low-temperature　NH3-SCR　catalysts　with　desired　SO2　and　H2O　resistance,　offering　valuable　insights　for　advancing　catalytic　performance　in　challenging　reaction　conditions.　©　2025　Elsevier　B.V.