The　aggregation　and　deposition　of　amyloid　proteins　are　considered　key　contributors　to　the　pathogenesis　of　various　diseases.　In　recent　years,　a　variety　of　nanoparticles　have　been　employed　to　modulate　amyloid　protein　aggregation.　Among　them,　silica　nanoparticles　(SNs)　have　emerged　as　particularly　promising　due　to　the　excellent　biocompatibility　of　silicon-based　materials　and　their　favorable　physicochemical　properties,　offering　significant　therapeutic　potential.　This　review　summarizes　recent　studies　on　the　use　of　SNs　to　regulate　the　aggregation　of　amyloid　proteins.　The　effects　of　different　types　and　surface-modified　SNs　on　the　aggregation　behavior　of　various　amyloid　proteins　are　systematically　compared,　aiming　to　provide　valuable　insights　for　future　research　and　potential　therapeutic　applications.　©　2025　Wiley-VCH　GmbH.