Background:　Septic　cardiomyopathy　is　an　acute　myocardial　injury　caused　by　sepsis　with　high　mortality.　Tricuspid　annular　plane　systolic　excursion　(TAPSE)　is　an　important　parameter　for　evaluating　right　ventricular　systolic　function,　but　its　relationship　with　prognosis　in　septic　cardiomyopathy　has　not　been　clearly　elucidated.　Methods:　This　retrospective　cohort　study　included　93　patients　diagnosed　with　septic　cardiomyopathy　admitted　to　the　intensive　care　unit　(ICU).　All　patients　underwent　TAPSE　measurements　within　24 h　of　admission　and　were　divided　into　abnormal　(TAPSE　＜　1.6 cm,　n = 33)　and　normal　(TAPSE　≥　1.6 cm,　n = 60)　groups.　The　primary　outcome　was　28-day　all-cause　mortality.　Kaplan–Meier　survival　analysis　was　used　to　compare　survival　rates　between　the　two　groups,　and　Cox　proportional　hazards　regression　models　were　used　to　assess　the　independent　association　between　TAPSE　and　28-day　mortality.　Receiver　operating　characteristic　(ROC)　curve　analysis　was　used　to　evaluate　the　predictive　value　of　TAPSE　for　prognosis　in　septic　cardiomyopathy.　Results:　Among　the　93　patients,　25　(26.8%)　died　within　28 days　after　ICU　admission.　The　mean　TAPSE　value　in　non-survivors　was　significantly　lower　than　in　survivors　(1.24 ± 0.21　vs.　1.72 ± 0.20 cm,　p ＜ 0.001).　Multivariate　Cox　regression　analysis　showed　that,　after　adjusting　for　age,　sex,　lactate　level,　APACHE　II　score,　left　ventricular　ejection　fraction,　and　troponin　I,　TAPSE　was　independently　associated　with　28-day　mortality.　Dose–response　relationship　analysis　indicated　a　negative　linear　relationship　between　TAPSE　values　and　28-day　mortality,　with　each　0.1 cm　decrease　in　TAPSE　associated　with　a　40%　increase　in　mortality　risk　(HR = 0.6,　95%　CI:　0.48–0.74,　p ＜ 0.001).　ROC　curve　analysis　showed　that　TAPSE　had　an　AUC　of　0.881　(95%　CI:　0.800–0.963)　for　predicting　28-day　mortality,　with　the　cut-off　determined　by　Youden’s　index　of　1.55 cm,　corresponding　to　a　sensitivity　of　80.0%　and　specificity　of　80.9%.　Conclusion:　TAPSE　is　independently　associated　with　28-day　mortality　in　patients　with　septic　cardiomyopathy　and　can　serve　as　a　valuable　indicator　for　assessing　short-term　prognosis　in　these　patients.　Incorporating　TAPSE　assessment　into　routine　examinations　for　septic　cardiomyopathy　patients　may　assist　in　identifying　high-risk　patients　early　for　clinical　monitoring.　Copyright　©　2025　Liu,　He,　Lin,　Lin,　Jiang,　Huang,　Shang　and　Wang.