Postoperative　abdominal　adhesions　are　the　most　common　complication　following　abdominopelvic　surgery,　posing　a　significant　burden　on　patients,　clinicians,　and　society.　However,　current　physical　barriers　often　involve　a　tradeoff　between　preventing　these　adhesions　and　inhibiting　inflammation.　Herein,　a　one-stone-two-birds　strategy　is　presented　to　address　this　challenge　through　an　injectable　intertwined　hydrogel　containing　sulfobetaine,　modified　aminocaproic　acid　(A6ACA),　and　ZnO　nanoparticles　(PSA-ZnO　hydrogel).　This　intertwined　network　is　stabilized　by　multiple　intermolecular　coordination　bonds,　including　hydrogen　bonds　and　electrostatic　interactions—enabling　facile　injection　and　resistance　to　abdominal　creep　stress.　Experimental　results　demonstrate　that　PSA-ZnO　hydrogel　fully　reduce　the　severity　of　peritoneal　adhesions　in　treated　rats　at　both　7-　and　14-days　post-surgery,　outperforming　commercially　available　hyaluronic　acid　(HA)　gel　due　to　its　superior　antifouling,　antibacterial　(＞　95%　clearance　of　E.　coli　and　S.　aureus,),　hemostatic　(55　s),　and　wound　healing　properties　(IL-6　and　TNF-α　decreased　and　VEGF　increased).　Unlike　conventional　barriers,　PSA-ZnO　prevents　foreign　body　formation　by　inhibiting　blood　clot　organization　and　pathologic　fibrin　accumulation　at　wound　sites.　This　integrated　approach　offers　a　clinically　translatable　solution　for　complete　prevention　of　postoperative　adhesions　and　inflammation,　with　the　potential　to　improve　patient　outcomes　and　reduce　healthcare　burdens.　©　2025　The　Author(s).　Advanced　Science　published　by　Wiley-VCH　GmbH.