Anoikis　is　a　programmed　cell　death　that　occurs　when　cells　detach　from　the　extracellular　matrix　(ECM).　Its　role　in　psoriasis　remains　unclear.　This　study　aims　to　explore　the　relationship　between　psoriasis　and　apoptosis,　focusing　on　anoikis-related　mechanisms.　Differentially　expressed　genes　(DEGs)　in　psoriasis　were　identified　using　the　GEO　database　and　overlapped　with　anoikis-related　genes　from　GeneCards　to　find　differentially　expressed　anoikis-related　genes　(DE-ARGs).　A　PPI　network　was　constructed,　revealing　eight　hub　DE-ARGs.　These　were　then　analyzed　using　GO,　KEGG　and　ssGSEA.　Immune　infiltration　cells　and　molecules　were　examined,　and　single-cell　data　analysis,　immunohistochemistry,　qRT-PCR,　Western　blotting,　gene　mapping,　and　drug　prediction　were　performed.　Eighteen　DE-ARGs　were　identified,　with　STAT3　and　BIRC5　as　key　DEGs.　Enrichment　analysis　showed　DE-ARGs　were　related　to　the　regulation　of　anoikis　and　positive　regulation　of　epithelial　cell　proliferation.　Notable　differences　in　dendritic　and　mast　cells　were　observed　between　psoriasis　lesions　and　no-lesion　samples.　Elevated　expression　of　BIRC5　and　STAT3　in　psoriasis　lesions　was　confirmed　through　qRT-PCR,　western　blotting　and　immunohistochemistry.　This　study　establishes　a　relationship　between　anoikis　and　psoriasis,　where　STAT3　and　BIRC5　play　important　roles.　STAT3　and　BIRC5　may　serve　as　potential　targets　for　the　prevention　and　treatment　of　psoriasis.