This　study　optimized　the　extraction　of　sesamin　and　4-hydroxy-sesamin　from　Cinnamomum　camphora　residue,　yielding　0.3804　%　under　conditions　of　86　degrees　C,　43　min,　and　a　1:8.39　solid-liquid　ratio.　The　purified　compounds　showed　67.86　%　and　78.87　%　recovery　rates　via　recrystallization.　In　LPS-induced　BV-2　microglia,　4hydroxy-sesamol　(10-40　mu　mol/L)　activated　autophagy,　reduced　iNOS,　COX-2,　IL-6,　IL-1　beta,　TNF-alpha　mRNA　expression,　and　demonstrated　neuroprotection　without　cytotoxicity,　suggesting　its　potential　in　mitigating　neuroinflammation.