Introduction:　We　investigated　the　importance　of　skin　microbiota　in　functional　dyspepsia　(FD)　based　on　the　skin-gut　axis　theory　and　revealed　potential　mechanisms.　This　study　also　validates　recent　popular　FD　treatments.　Methods:　We　used　mendelian　randomization　(MR)　to　analyze　418　gut　bacteria　and　145　skin　bacteria,　identifying　key　symbionts　in　FD　development.　Bibliometric　keyword　analysis　was　conducted　on　current　FD　therapies.　Finally,　we　used　a　mouse　model　of　FD　to　assess　body　weight,　food　intake,　gastric　residue　rate,　small　intestine　transit　rate,　and　fecal　water　content　after　interventions　with　skin-gut　symbionts　and　treatment　methods.　Hematoxylin-eosin　staining　observed　gastric　antrum　tissue　morphology.　RhoA　and　ROCK1　protein　and　mRNA　levels　in　gastric　antrum　tissue　were　detected　by　western　blot　and　real-time　PCR.　Fluorescence　immunoassay　observed　ROCK1　and　vesicular　acetylcholine　transporter　(VAChT)　protein　expression.　Results:　Streptococcus　has　a　causal　relationship　with　FD.　Bibliometric　analysis　highlighted　electroacupuncture　as　a　research　hotspot.　Skin　Streptococcus　colonization　reduced　food　intake,　body　weight,　small　intestine　transit　rate,　and　increased　gastric　residue　rate　in　FD　mice,　decreasing　RhoA,　ROCK1,　and　VAChT　protein　and　mRNA　levels.　Antibiotics　reversed　these　effects.　Electroacupuncture　improved　weight,　appetite,　gastrointestinal　motility,　and　RhoA,　ROCK1,　and　VAChT　protein,　and　mRNA　levels　in　FD　mice.　Conclusion:　The　study　confirmed　the　pathogenic　role　of　skin　Streptococcus　in　FD　and　the　therapeutic　value　of　electroacupuncture　at　Tianshu　acupoint,　potentially　via　RhoA/ROCK1　signaling　pathway　regulation.