Rationale:The　opportunistic　pathogen　Corynebacterium　striatum　has　been　generating　more　clinical　infections　in　recent　years,　but　secondary　infections　at　different　parts　caused　by　it　have　been　reported　more　rarely.Patient　concerns:This　case　details　a　52-year-old　male　patient　who　got　an　infection　that　advanced　to　multiple　osteomyelitis　and　soft　tissue　abscess　after　block　therapy　for　external　humeral　epicondylitis　of　the　right　arm.　Unexpectedly,　the　chronic　ulcerated　region　of　the　patient＇s　neck　was　infested　with　Corynebacterium　striatum　due　to　inadequate　treatment　of　the　main　infection,　resulting　in　a　secondary　infection　of　the　neck　mass.Diagnoses:Microbiological　cultures　of　the　pus　from　the　right　elbow　and　neck　indicated　an　infection　with　Corynebacterium　striatum　at　both　sites.Interventions:We　initiated　antimicrobial　therapy　with　linezolid　(600　mg)　in　conjunction　with　Fosfomycin　(4　g)　every　12　hours.Outcomes:After　4　weeks　of　treatment,　the　infected　lesion　was　resolved　as　evidenced　by　a　repeat　magnetic　resonance　imaging　compared　to　the　prior　scan.Lessons:This　case　not　only　demonstrates　the　significant　pathogenicity　of　Corynebacterium　striatum　but　also　warns　that　traumatic　locations,　such　as　swellings　resulting　from　chronic　ulcers　in　the　neck,　may　become　prospective　targets　for　this　bacterium.