Chronic　wound　healing　remains　a　major　challenge　in　diabetes　management　due　to　prolonged　inflammation,　autonomic　neuropathy,　and　bacterial　infections.　In　particular,　multidrug-resistant　bacterial　infections　are　important　to　the　development　of　diabetic　wounds,　leading　to　persistent　inflammation　and　delayed　healing.　To　address　this　issue,　we　developed　a　self-adaptive　nanozyme　designed　to　modulate　infectious　and　inflammatory　microenvironments　by　doping　Ce　and　Ag　into　mesoporous　silicon　nanomaterials　(MSNs).　The　resulting　CA@MSNs　exhibited　strong　bacterial　capture　capabilities　via　electrostatic　attraction.　Additionally,　the　synergistic　effects　of　Ce　and　Ag　endowed　CA@MSNs　with　peroxidase　(POD)-like　activity,　enabling　the　generation　of　reactive　oxygen　species　(ROS)　to　eradicate　bacteria　in　infectious　microenvironments.　Notably,　CA@MSNs　also　demonstrated　the　ability　to　scavenge　a　broad　spectrum　of　ROS,　including　hydroxyl　free　radicals,　hydrogen　peroxide,　and　superoxide　radicals,　in　inflammatory　microenvironments.　This　dual　functionality　helped　mitigate　inflammation　and　promote　endothelial　cell　migration.　Consequently,　treatment　with　CA@MSNs　significantly　reduced　inflammation,　enhanced　fibroblast　activation,　and　facilitated　collagen　deposition,　ultimately　accelerating　the　healing　of　methicillin-resistant　Staphylococcus　aureus　(MRSA)-infected　wounds　in　diabetic　mice.　In　conclusion,　this　study　presents　a　promising　therapeutic　strategy　for　chronic　diabetic　wounds,　offering　a　novel　approach　to　overcoming　infection-related　healing　delays.