As　a　model　compound　for　lignin　derivatives,　anisole　and　its　conversion　are　crucial　for　the　upgrading　of　biomass　resources.　Anisole　molecule　contains　a　characteristic　aryl　ether　bond　(Caryl-O-CH3);　therefore,　the　selective　cleavage　of　the　C-O　bond　to　efficiently　produce　high-value　chemicals　poses　a　significant　challenge.　Constructing　bimetallic　synergistic　active　sites　through　tuning　the　metal-support　interface　is　considered　an　effective　strategy.　In　this　work,　the　WO3-promoted　Pt/SiO2　catalysts　were　investigated　to　enhance　the　performance　of　anisole　hydrodeoxygenation　(HDO)　to　hydrocarbons.　Experimental　results　demonstrate　that　WO3　significantly　promotes　HDO　selectivity,　increasing　from　37.8%　to　86.8%　at　250　°C.　Moreover,　moderate　doping　improves　low-temperature　(3　suppresses　anisole　conversion.　Characterization　results　reveal　that　WO3　stabilizes　metallic　Pt　and　facilitates　H2　dissociation.　Concurrently,　strong　hydrogen　spillover　between　Pt　and　WO3　promotes　oxygen　vacancy　formation　on　WO3.　This　transforms　disordered　adsorption　of　anisole　on　SiO2　into　directed　adsorption　of　the　anisole’s　oxygen　species　onto　WO3.　This　work　achieves　high　anisole　HDO　selectivity　through　the　Pt-WO3　interface　tuning,　offering　novel　insights　for　efficient　lignin　conversion.　©　2025　by　the　authors.