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author:

Wang, Kaijie (Wang, Kaijie.) [1] | Alam, Md Jahangir (Alam, Md Jahangir.) [2] | Lan, Xinya (Lan, Xinya.) [3] | Li, Fei (Li, Fei.) [4] | Chen, Jiande D. Z. (Chen, Jiande D. Z..) [5]

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EI

Abstract:

Disorders of gut-brain interaction (DGBI), including irritable bowel syndrome (IBS), have a significant impact on patients, reducing their quality of life and work efficiency. Pharmacological therapy is primarily used as a frontline treatment option for treating IBS. However, owing to the heterogeneous characteristics of IBS and its limited pathophysiological understanding, pharmacological therapy is rather disappointing. Therefore, patients with IBS often use alternative therapies, such as electrical neuromodulation, to treat IBS-related symptoms. Neuromodulation includes invasive and noninvasive methods via implanted electrodes and transcutaneous electrodes, respectively. In this manuscript, we reviewed the therapeutic effects of several electrical neuromodulation approaches, including sacral nerve stimulation, spinal cord stimulation, auricular vagal nerve stimulation, and transcutaneous electrical acustimulation, on the symptoms of IBS. Additionally, we discussed the potential mechanisms, adverse effects, advantages, and disadvantages of different neuromodulation treatment methods. © The Author(s) 2025.

Keyword:

Brain Diseases Electrodes Electrophysiology Noninvasive medical procedures

Community:

  • [ 1 ] [Wang, Kaijie]Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 1150 E Medical Center Dr, Ann Arbor; MI; 48109, United States
  • [ 2 ] [Wang, Kaijie]Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Zhejiang, Hangzhou; 310003, China
  • [ 3 ] [Alam, Md Jahangir]Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 1150 E Medical Center Dr, Ann Arbor; MI; 48109, United States
  • [ 4 ] [Lan, Xinya]Rehabilitation Medicine Center, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China
  • [ 5 ] [Lan, Xinya]Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China
  • [ 6 ] [Li, Fei]Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 1150 E Medical Center Dr, Ann Arbor; MI; 48109, United States
  • [ 7 ] [Chen, Jiande D. Z.]Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 1150 E Medical Center Dr, Ann Arbor; MI; 48109, United States

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Bioelectronic Medicine

Year: 2025

Issue: 1

Volume: 11

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ESI Highly Cited Papers on the List: 0 Unfold All

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30 Days PV: 0

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