Pressure　ulcers,　resulting　from　prolonged　external　pressure　or　shear　forces　on　skin　and　underlying　tissues　over　bony　prominences,　lead　to　tissue　ischemia　and　impaired　lymphatic　drainage.　Without　timely　intervention,　these　wounds　can　progress　to　severe　complications　including　cellulitis,　chronic　infections,　and　osteomyelitis.　In　this　study,　we　developed　a　chitosan/sodium　β-glycerophosphate/gelatin　(CS/β-GP/GEL)　thermosensitive　hydrogel　system　to　enhance　the　therapeutic　efficacy　of　adipose-derived　mesenchymal　stem　cells　(ADSCs)　in　pressure　ulcer　healing.　The　incorporation　of　gelatin　addresses　the　limitations　of　conventional　CS/β-GP　hydrogels,　such　as　low　mechanical　strength　and　poor　biocompatibility.　The　optimized　CS/β-GP/GEL　hydrogel　exhibits　good　injectability,　suitable　gel　formation　time　and　pH,　facilitating　efficient　ADSCs　encapsulation.　Furthermore,　the　hydrogel　demonstrates　good　water　absorption　capacity,　degradability,　and　rheological　properties,　making　it　suitable　for　biomedical　applications.　In　vitro　studies　confirmed　the　hydrogel＇s　high　cytocompatibility,　supporting　ADSCs　viability　and　proliferation.　Additionally,　the　CS/β-GP/GEL@ADSC　composite　demonstrated　pro-angiogenic　properties,　suppressed　reactive　oxygen　species-mediated　apoptosis,　and　facilitated　the　accumulation　of　M2-type　macrophages.　In　vivo　evaluations　revealed　that　the　CS/β-GP/GEL@ADSC　composite　had　high　histocompatibility　and　accelerated　pressure　ulcer　healing　in　a　rat　model,　mediated　through　enhanced　angiogenesis,　M2-dominant　macrophage　polarization,　and　improved　extracellular　matrix　remodeling.　These　findings　highlight　the　potential　of　CS/β-GP/GEL@ADSC　as　a　promising　therapeutic　strategy　for　pressure　ulcer　management.　©　2025　Elsevier　B.V.