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学者姓名：魏巧华
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Abstract ：
The yolk-shell structure has become a research hotspot in the field of photocatalysis in recent years due to its stability, movable yolk, and internal voids. However, yolk-shell has not been fully explored and applied in photoelectrochemical (PEC) immunoassays. In this work, a smartphone-based portable PEC immunoassay was constructed by using high-entropy yolk-shell Au@(ZnCdMnGaCu)(x)S as a photosensitive material, showing satisfactory detection with the assistance of localized surface plasmon resonance (LSPR). Specifically, a typical sandwich reaction introduces a detection antibody modified and labeled with gold nanoparticles (Au NPs) of alkaline phosphatase (ALP) into the system with the presence of prostate-specific antigen (PSA). Ascorbic acid (AA) content increased with increasing PSA and showed a linear enhancement of photocurrent at PSA concentrations of 0.01-50 ng mL(-1) with a limit of detection of 8.94 pg mL(-1). Additionally, the proposed assay technology not only provides a portable detection system for the immediate detection of tumor markers, but also offers a promising paradigm for the development of high-entropy materials.
Keyword ：
High-entropy yolk-shell Au@(ZnCdMnGaCu)(x)S High-entropy yolk-shell Au@(ZnCdMnGaCu)(x)S Localized surface plasmon resonance Localized surface plasmon resonance Photoelectrochemical immunoassay Photoelectrochemical immunoassay Portable inspection system Portable inspection system Prostate-specific antigen Prostate-specific antigen Smartphone Smartphone
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| GB/T 7714 | Wan, Xinyu , Wang, Xin , Wang, Haiyang et al. Localized surface plasmon resonance-enhanced photoelectrochemical immunoassay based on high-entropy yolk-shell Au@(ZnCdMnGaCu)xS [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2025 , 422 . |
| MLA | Wan, Xinyu et al. "Localized surface plasmon resonance-enhanced photoelectrochemical immunoassay based on high-entropy yolk-shell Au@(ZnCdMnGaCu)xS" . | SENSORS AND ACTUATORS B-CHEMICAL 422 (2025) . |
| APA | Wan, Xinyu , Wang, Xin , Wang, Haiyang , Wei, Qiaohua , Tang, Dianping . Localized surface plasmon resonance-enhanced photoelectrochemical immunoassay based on high-entropy yolk-shell Au@(ZnCdMnGaCu)xS . | SENSORS AND ACTUATORS B-CHEMICAL , 2025 , 422 . |
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Photocurrent-polarity conversion strategies are typically realized by constructing complex photovoltaic electrodes or changing the relevant conditions, but most involve poor photogenerated carrier transfer efficiency and cumbersome experimental steps. To this end, a photoelectrochemical (PEC) biosensor by utilizing ascorbic acid (AA)-induced photocurrent-polarity-switching was proposed for the detection of carcinoembryonic antigen (CEA). Under light excitation, the electron donor AA was oxidized by the photogenerated holes of photoactive material Co-NC/CdS, resulting in the conversion of cathodic photocurrent to the anodic direction. In the presence of the target CEA, alkaline phosphatase (ALP) was introduced into the microplates by the sandwiched immunoreaction, which then catalyzed the production of AA from ascorbic acid-2-phosphate (AAP). Finally, the catalytic product AA was transferred onto Co-NC/CdS-modified screen-printed carbon electrode, thus activating photocurrent-polarity-switching platform. The anodic photocurrent values gradually increased with increasing CEA concentration in the range of 0.02-80 ng mL(-1) and reached a limit of detection (LOD) of 8.47 pg mL(-1) (S/N = 3). In addition, the results of actual sample detection prove the reliability of the constructed PEC biosensor. Importantly, this work relies on a mobile smartphone wireless Bluetooth device coupled with the PEC biosensor for immediate detection, providing another idea for detecting CEA in clinical diagnosis.
Keyword ：
Carcinoembryonic antigen Carcinoembryonic antigen Photocurrent-polarity-switching Photocurrent-polarity-switching Photoelectrochemical immunoassay Photoelectrochemical immunoassay Point-of-care Point-of-care Wireless bluetooth Wireless bluetooth
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| GB/T 7714 | Wang, Xin , Wang, Haiyang , Wan, Xinyu et al. Smartphone-based point-of-care photoelectrochemical immunoassay coupling with ascorbic acid-triggered photocurrent-polarity conversion switching [J]. | BIOSENSORS & BIOELECTRONICS , 2025 , 267 . |
| MLA | Wang, Xin et al. "Smartphone-based point-of-care photoelectrochemical immunoassay coupling with ascorbic acid-triggered photocurrent-polarity conversion switching" . | BIOSENSORS & BIOELECTRONICS 267 (2025) . |
| APA | Wang, Xin , Wang, Haiyang , Wan, Xinyu , Wei, Qiaohua , Zeng, Yongyi , Tang, Dianping . Smartphone-based point-of-care photoelectrochemical immunoassay coupling with ascorbic acid-triggered photocurrent-polarity conversion switching . | BIOSENSORS & BIOELECTRONICS , 2025 , 267 . |
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Accurate and rapid identification of expired and spoiled food is crucial for food conservation, reducing resource wastage, and preventing food poisoning. This paper presents a portable electrochemical sensing platform supported by a miniature electrochemical workstation and an intelligent pH recognition system, enabling detection of L-lactic acid (L-LA) in food products without enzyme involvement. The system was based on a Cu2O@CuO multifaceted extended spatial hexapod structure. The synthesized Cu2O@CuO was characterized by a welldefined multifaceted structure. Significant enzyme-free catalysis was exhibited, and pH responses dominated by anthocyanins were identified through an intelligent image acquisition system. Additionally, we developed an electrochemical detection device for pH assistance during target testing, addressing the limitations of current electrochemical sensors' complex signal acquisition components using 3D-printed fabrication techniques and smartphones. The proposed multifunctional electrochemical workbench based on Cu2O@CuO was found to offer a preferable linear detection range of 0.1-1000 mu M for L-LA, with a low detection limit of 0.027 mu M. The visualization of pH determination was introduced as a novel approach for developing advanced electrochemical workbenches. In conclusion, pH-assisted portable electrochemical detection systems hold great potential for immediate food safety identification, particularly in resource-limited areas, facilitating prompt diagnosis and ensuring food safety.
Keyword ：
3D-printed device 3D-printed device Electrochemical detection Electrochemical detection Enzyme-free catalysis Enzyme-free catalysis Food quality evaluation Food quality evaluation Visualization Visualization
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| GB/T 7714 | Wu, Di , Wei, Qiaohua , Yu, Zhichao et al. Miniature dual-channel electrochemical 3D-printed sensing platform for enzyme-free screening of L-lactic acid in foodstuffs accompanying pH recognition [J]. | FOOD CHEMISTRY , 2025 , 465 . |
| MLA | Wu, Di et al. "Miniature dual-channel electrochemical 3D-printed sensing platform for enzyme-free screening of L-lactic acid in foodstuffs accompanying pH recognition" . | FOOD CHEMISTRY 465 (2025) . |
| APA | Wu, Di , Wei, Qiaohua , Yu, Zhichao , Gao, Yuan , Knopp, Dietmar , Tang, Dianping . Miniature dual-channel electrochemical 3D-printed sensing platform for enzyme-free screening of L-lactic acid in foodstuffs accompanying pH recognition . | FOOD CHEMISTRY , 2025 , 465 . |
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Due to unique framework structures, Prussian blue analogs (PBAs) have long been of considerable interest in biosensing. However, the predominantly cubic morphology of most PBAs, along with their inherent elemental and structural limitations, restricts their catalytic performance as the nanozymes. Herein, we designed a dualmetal CuFe/Fe PBA nanozyme composite (CuFe/Fe DMPBA) exhibiting excellent peroxidase (POD)-like activity. The synthesized FePBA was prismatically loaded along the inner core CuFe PBA to build an epitaxially deposited structure. This unique architecture resulted in a substantial enhancement of the POD-like activity of the composite nanozyme compared to its individual components, FePBA and CuFe PBA. Leveraging the superior catalytic performance of the synthesized CuFe/Fe DMPBA, we further developed a highly sensitive and selective colorimetric immunoassay platform for the detection of human epidermal growth factor receptor 2 (HER2), a crucial biomarker of cancer. Under optimized conditions, this nanozyme-based immunoassay platform achieved a limit of detection (LOD) of 0.007 ng mL- 1 and a linear range from 0.01 to 10 ng mL- 1 for HER2 detection. This work not only presents a novel strategy for synthesizing high-performance PBA-based nanozymes, but also provides insights for the rational design and application of PBA materials in bioanalytical sensing.
Keyword ：
Colorimetric immunoassay Colorimetric immunoassay Dual-metal CuFe/Fe nanozyme Dual-metal CuFe/Fe nanozyme Human epidermal growth factor receptor 2 Human epidermal growth factor receptor 2 Nanozyme Nanozyme Prussian blue analogue Prussian blue analogue
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| GB/T 7714 | Lao, Shuqun , Wang, Haiyang , Wu, Di et al. Dual-metal CuFe/Fe cube nanozyme with Prussian blue analogue for highly efficient colorimetric immunoassay [J]. | BIOSENSORS & BIOELECTRONICS , 2025 , 287 . |
| MLA | Lao, Shuqun et al. "Dual-metal CuFe/Fe cube nanozyme with Prussian blue analogue for highly efficient colorimetric immunoassay" . | BIOSENSORS & BIOELECTRONICS 287 (2025) . |
| APA | Lao, Shuqun , Wang, Haiyang , Wu, Di , Wei, Qiaohua , Tang, Dianping . Dual-metal CuFe/Fe cube nanozyme with Prussian blue analogue for highly efficient colorimetric immunoassay . | BIOSENSORS & BIOELECTRONICS , 2025 , 287 . |
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The quantification of intracellular hydrogen peroxide (H2O2) serves as a critical biomarker for characterizing cellular physiological states, providing essential insights into metabolic regulation and signaling pathways. This analytical paradigm not only advances our understanding of pathological mechanisms but also contributes to the development of novel diagnostic approaches and precision therapeutic interventions. Herein, we established an innovative electrochemical microsensing platform capable of discriminating between malignant and normal cells through their distinct inflammatory responses under external stimulation. This innovative methodology integrates three critical technical advancements: (i) optimization of a one-pot microwave synthesis protocol for fabricating high-performance PtZnCd nanoparticles anchored on multi-walled carbon nanotubes (MWCNTs), which serve as the core sensing element; (ii) systematic electrochemical characterization coupled with density functional theory (DFT) calculations demonstrating that this hybrid architecture significantly reduces interfacial charge-transfer resistance while enhancing heterogeneous electron transfer kinetics; (iii) comprehensive biocompatibility evaluations confirming the composite material's favorable cytotoxicity profile and biological safety, supporting its potential for cellular classification applications. Through real-time monitoring of dynamic metabolic fluctuations and intracellular inflammatory microenvironment changes in response to ascorbic acid (AA) and dehydroascorbic acid (DHA) stimulation, we established distinct response signatures that effectively differentiate neoplastic cells from their healthy counterparts. This study introduces an innovative electrochemical sensing paradigm that synergistically combines biocompatible nanocatalysts with inflammatory microenvironment dynamics, establishing a robust platform for dual discrimination between cancerous and normal cells, with significant implications for biomedical research and clinical diagnostics. © 2025 Elsevier B.V.
Keyword ：
Multiwalled carbon nanotubes (MWCN) Multiwalled carbon nanotubes (MWCN)
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| GB/T 7714 | Xu, Man , Yu, Zhichao , Wei, Qiaohua et al. Inflammatory microenvironment-responsive electrochemical biosensing for cancer cell discrimination using PtZnCd-anchored multi-walled carbon nanotubes [J]. | Talanta , 2025 , 294 . |
| MLA | Xu, Man et al. "Inflammatory microenvironment-responsive electrochemical biosensing for cancer cell discrimination using PtZnCd-anchored multi-walled carbon nanotubes" . | Talanta 294 (2025) . |
| APA | Xu, Man , Yu, Zhichao , Wei, Qiaohua , Tang, Dianping . Inflammatory microenvironment-responsive electrochemical biosensing for cancer cell discrimination using PtZnCd-anchored multi-walled carbon nanotubes . | Talanta , 2025 , 294 . |
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A series of gold (I) phoshpine complexes with diverse alkynyl ligands [Au(C equivalent to CR)(PTA)] (R=C6H11OH, 1; C5H9OH, 2; C15H11OH, 3; C19H27O2, 4; C18H23O2, 5; C9H12N, 6; CH2OCH2C6H5, 7; C6H4OCH3, 8; PTA=1,3,5-Triaza-7-phosphaadamantane) have been synthesized and characterized using a range of spectroscopic techniques. Complex 1 and 3 show an infinite one-dimensional S-type and zigzag aurophilic chain, respectively, whereas complex 2 containing 1-ethynyl-1-cyclohexanol gives an approximate linear two-dimensional aurophilic chain, through intra/intermolecular Au(I)& ctdot;Au(I) interactions as well as hydrogen bonding interactions between hydroxy groups of alkynyl ligands and PTA. Solid complexes 1-8 display strongly room/low-temperature emissive of 477-613 nm with the emission lifetime of 0.40-14.0 mu s. All the complexes display higher cytotoxicities against MCF-7, with the cytotoxicity decreasing in the following order 4>8>5>3>7>6>2>1. Complex 4 and 5 stand out for the highest selectivity towards MCF-7 (IC50=0.63-0.78 mu M) compared with normal human embryonic lung fibroblasts (helf) (IC50=14.85-18.13 mu M), which makes those complexes attractive for breast cancer therapy.
Keyword ：
alkynyl gold (I) phoshpine complexes alkynyl gold (I) phoshpine complexes cytotoxicity cytotoxicity luminescence luminescence structure-activity relationships structure-activity relationships
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| GB/T 7714 | Lin, Tingting , Lin, Yanyan , Yao, Junfei et al. Alkynyl Gold(I) Phosphine Complexes: Evaluation of Structure-Activity Relationships for the Alkynyl Ligands on Luminescence and Cytotoxicity [J]. | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY , 2024 , 27 (18) . |
| MLA | Lin, Tingting et al. "Alkynyl Gold(I) Phosphine Complexes: Evaluation of Structure-Activity Relationships for the Alkynyl Ligands on Luminescence and Cytotoxicity" . | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY 27 . 18 (2024) . |
| APA | Lin, Tingting , Lin, Yanyan , Yao, Junfei , Wu, Zhongwei , Fu, Nanyan , Wei, Qiaohua . Alkynyl Gold(I) Phosphine Complexes: Evaluation of Structure-Activity Relationships for the Alkynyl Ligands on Luminescence and Cytotoxicity . | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY , 2024 , 27 (18) . |
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介绍了一个研究型综合化学实验——具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究。本实验基于氧化还原反应和配位反应合成Cu(I)配合物，采用薄层色谱法判断合成反应进程，运用配位滴定法测定其铜含量，利用荧光光度法和荧光定量分析法测定固态荧光以及判断产品的纯度。本实验综合了无机化学、有机化学、分析化学的基础知识和实验技能以及大型仪器的学习和操作，同时体现了发光金属配合物这一科研热点，探究物质结构与性质的关系。通过本实验的实践，学生在巩固所学实验知识和实验技能的同时，训练了运用所学知识解决实际问题的综合能力，有利于学生初步建立科学的思维方式和研究能力。
Keyword ：
发光性能 发光性能 综合化学实验 综合化学实验 铜(I)配合物 铜(I)配合物 铜含量分析 铜含量分析
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| GB/T 7714 | 郑琤 , 郑诗颖 , 张艳萍 et al. 具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究——推荐一个综合化学实验 [J]. | 大学化学 , 2024 , 39 (07) : 322-329 . |
| MLA | 郑琤 et al. "具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究——推荐一个综合化学实验" . | 大学化学 39 . 07 (2024) : 322-329 . |
| APA | 郑琤 , 郑诗颖 , 张艳萍 , 郑寿添 , 魏巧华 . 具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究——推荐一个综合化学实验 . | 大学化学 , 2024 , 39 (07) , 322-329 . |
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介绍了一个研究型综合化学实验——具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究.本实验基于氧化还原反应和配位反应合成Cu(Ⅰ)配合物,采用薄层色谱法判断合成反应进程,运用配位滴定法测定其铜含量,利用荧光光度法和荧光定量分析法测定固态荧光以及判断产品的纯度.本实验综合了无机化学、有机化学、分析化学的基础知识和实验技能以及大型仪器的学习和操作,同时体现了发光金属配合物这一科研热点,探究物质结构与性质的关系.通过本实验的实践,学生在巩固所学实验知识和实验技能的同时,训练了运用所学知识解决实际问题的综合能力,有利于学生初步建立科学的思维方式和研究能力.
Keyword ：
发光性能 发光性能 综合化学实验 综合化学实验 铜含量分析 铜含量分析 铜(Ⅰ)配合物 铜(Ⅰ)配合物
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| GB/T 7714 | 郑琤 , 郑诗颖 , 张艳萍 et al. 具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究 [J]. | 大学化学 , 2024 , 39 (7) : 322-329 . |
| MLA | 郑琤 et al. "具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究" . | 大学化学 39 . 7 (2024) : 322-329 . |
| APA | 郑琤 , 郑诗颖 , 张艳萍 , 郑寿添 , 魏巧华 . 具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究 . | 大学化学 , 2024 , 39 (7) , 322-329 . |
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Developing novel electrocatalysts for achieving high selectivity and faradaic efficiency in the carbon dioxide reduction reaction (CO2RR) poses a major challenge. In this study, a catalyst featuring a nitrogen-doped carbon shell-coated Ni nanoparticle structure is designed for efficient carbon dioxide (CO2) electroreduction to carbon monoxide (CO). The optimal Ni@NC-1000 catalyst exhibits remarkable CO faradaic efficiency (FECO) values exceeding 90% across a broad potential range of -0.55 to -0.9 V (vs. RHE), and attains the maximum FECO of 95.6% at -0.75 V (vs. RHE) in 0.5 M NaHCO3. This catalyst exhibits sustained carbon dioxide electroreduction activity with negligible decay after continuous electrolysis for 20 h. More encouragingly, a substantial current density of 200.3 mA cm(-2) is achieved in a flow cell at -0.9 V (vs. RHE), reaching an industrial-level current density. In situ Fourier transform infrared spectroscopy and theoretical calculations demonstrate that its excellent catalytic performance is attributed to highly active pyrrolic nitrogen sites, promoting CO2 activation and significantly reducing the energy barrier for generating *COOH. To a considerable extent, this work presents an effective strategy for developing high-efficiency catalysts for electrochemical CO2 reduction across a wide potential window.
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| GB/T 7714 | Peng, Ying , Chen, Shuo , Hu, Zhengli et al. Guanine-derived carbon nanosheet encapsulated Ni nanoparticles for efficient CO2 electroreduction [J]. | DALTON TRANSACTIONS , 2024 , 53 (23) : 9724-9731 . |
| MLA | Peng, Ying et al. "Guanine-derived carbon nanosheet encapsulated Ni nanoparticles for efficient CO2 electroreduction" . | DALTON TRANSACTIONS 53 . 23 (2024) : 9724-9731 . |
| APA | Peng, Ying , Chen, Shuo , Hu, Zhengli , Yin, Mengqi , Pei, Lishun , Wei, Qiaohua et al. Guanine-derived carbon nanosheet encapsulated Ni nanoparticles for efficient CO2 electroreduction . | DALTON TRANSACTIONS , 2024 , 53 (23) , 9724-9731 . |
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Background: Measurement of endogenous cellular hydrogen peroxide (H2O2) 2 O 2 ) can provide information on cellular status, and help to understand cellular metabolism and signaling processes, thus contributing to elucidation of disease mechanisms and new diagnostics/therapeutic approaches. Results: In this work, Pt-Cd bimetallic nanozyme was successfully prepared via the solvothermal synthetic method for sensitive detection of H2O2. 2 O 2 . The synthesized Pt-Cd bimetallic nanozyme could exhibited good electrochemical activity. Then, the materials were analyzed for the electrochemical properties and catalytic properties of H2O2 2 O 2 by cyclic voltammetry and chronoamperometry, respectively. Results indicated that the synthesized nanozyme had superior sensitivity (295 mu A mM- 1 cm- 2 ) and selectivity toward H2O2 2 O 2 with a detection limit of 0.21 mu M. Further, the Pt-Cd bimetallic nanozyme displayed good electrochemical properties compared to platinum catalysts alone. The application was extended to determine the produced H2O2 2 O 2 from human hepatocellular carcinoma cells (HepG2) and normal hepatocyte (LO2) samples after ascorbic acid stimulation, thus enabling the early warning of cellular carcinogenesis. Significance: This strategy promises simple, rapid, inexpensive and effective electrochemical sensing and provides a new pathway for the synthesis of bimetallic nanozymes to construct an electrochemical sensor for the sensitive detection of H2O2. 2 O 2 .
Keyword ：
Enzyme-free electrochemical sensor Enzyme-free electrochemical sensor Hepatocellular carcinoma cells Hepatocellular carcinoma cells Intracellularly-originated hydrogen peroxide Intracellularly-originated hydrogen peroxide Pt-Cd bimetallic nanozyme Pt-Cd bimetallic nanozyme
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| GB/T 7714 | Xu, Man , Yu, Zhichao , Wei, Qiaohua et al. Probing trace of intracellularly-originated hydrogen peroxide based Pt-Cd - Cd bimetallic nanozyme on an enzyme-free electrochemical sensor [J]. | ANALYTICA CHIMICA ACTA , 2024 , 1324 . |
| MLA | Xu, Man et al. "Probing trace of intracellularly-originated hydrogen peroxide based Pt-Cd - Cd bimetallic nanozyme on an enzyme-free electrochemical sensor" . | ANALYTICA CHIMICA ACTA 1324 (2024) . |
| APA | Xu, Man , Yu, Zhichao , Wei, Qiaohua , Tang, Dianping . Probing trace of intracellularly-originated hydrogen peroxide based Pt-Cd - Cd bimetallic nanozyme on an enzyme-free electrochemical sensor . | ANALYTICA CHIMICA ACTA , 2024 , 1324 . |
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