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学者姓名：陈鲤群
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Abstract ：
The gut bacteria not only play a crucial role in maintaining human health but also exhibit close associations with the occurrence of numerous diseases. Understanding the physiological and pathological functions of gut bacteria and enabling early diagnosis of gut diseases heavily relies on accurate knowledge about their in vivo distribution. Consequently, there is a significant demand for noninvasive imaging techniques capable of providing real-time localization information regarding gut bacteria. In this work, we developed a second near-infrared (NIR-II) fluorescent nanoprobe labeling-based visualization strategy for real-time tracking of the biodistribution of Gram-negative bacteria in the gastrointestinal tract of mice. By utilizing positively charged silver sulfide quantum dots (Ag2S QDs) as NIR-II nanoprobes and exploiting electrostatic interactions to efficiently label the Gram-negative probiotic Escherichia coli Nissle 1917 with negative surface charges, we have achieved rapid and effective labeling. Leveraging the exceptional NIR-II fluorescent performance of Ag2S QDs, our approach enables high spatiotemporal resolution visualization via NIR-II imaging in mouse gastrointestinal areas where Ag2S QD-labeled probiotics are present, facilitating real-time in vivo tracking capabilities for these labeled probiotics. This work not only establishes a powerful intestinal bacterial imaging strategy but also introduces novel concepts for constructing nanomaterial-bacteria hybrid systems.
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| GB/T 7714 | Chen, Wenwen , Chen, Rong , Sun, Yutong et al. Facile Labeling of Gram-Negative Bacteria with NIR-II Fluorescent Nanoprobes for Intestinal Bacteria Imaging [J]. | ACS OMEGA , 2025 , 10 (2) : 2044-2050 . |
| MLA | Chen, Wenwen et al. "Facile Labeling of Gram-Negative Bacteria with NIR-II Fluorescent Nanoprobes for Intestinal Bacteria Imaging" . | ACS OMEGA 10 . 2 (2025) : 2044-2050 . |
| APA | Chen, Wenwen , Chen, Rong , Sun, Yutong , Wang, Han , Chen, Zhenyu , Chen, Liqun et al. Facile Labeling of Gram-Negative Bacteria with NIR-II Fluorescent Nanoprobes for Intestinal Bacteria Imaging . | ACS OMEGA , 2025 , 10 (2) , 2044-2050 . |
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The complex tumor structure and microenvironment such as abnormal tumor vasculature, dense tumor matrix, and elevated interstitial fluid pressure greatly hinder the penetration and retention of therapeutic agents in solid tumors. The development of an advanced method for robust penetration and retention of therapeutic agents in tumors is of great significance for efficient tumor treatments. In this work, we demonstrated that magnetotactic bacteria AMB-1 with hypoxic metabolism characteristics can actively penetrate the tumor to selectively colonize deep hypoxic regions, which emerge as a promising intelligent drug carrier. Furthermore, AMB-1 presents intrinsic second near-infrared (NIR-II) photothermal performance that can efficiently convert a 1064 nm laser into heat for tumor thermal ablation. We believe that our investigations not only develop a novel bacteria-based photothermal agent but also provide useful insights for the development of advanced tumor microbial therapies.
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| GB/T 7714 | Huang, Guoming , Zhu, Guifen , Lin, Ruipeng et al. Magnetotactic Bacteria AMB-1 with Active Deep Tumor Penetrability for NIR-II Photothermal Tumor Therapy [J]. | ACS OMEGA , 2024 , 9 (21) : 23060-23068 . |
| MLA | Huang, Guoming et al. "Magnetotactic Bacteria AMB-1 with Active Deep Tumor Penetrability for NIR-II Photothermal Tumor Therapy" . | ACS OMEGA 9 . 21 (2024) : 23060-23068 . |
| APA | Huang, Guoming , Zhu, Guifen , Lin, Ruipeng , Chen, Wenwen , Chen, Rong , Sun, Yutong et al. Magnetotactic Bacteria AMB-1 with Active Deep Tumor Penetrability for NIR-II Photothermal Tumor Therapy . | ACS OMEGA , 2024 , 9 (21) , 23060-23068 . |
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The Nab-paclitaxel combined with gemcitabine (AG) regimen is the main chemotherapy regimen for pancreatic cancer, but drug resistance often occurs. Currently, the ability to promote sensitization in drug-resistant cases is an important clinical issue, and the strategy of repurposing conventional drugs is a promising strategy. This study aimed to identify a classic drug that targets chemotherapy resistance's core signaling pathways and combine it with the AG regimen to enhance chemosensitivity. We also aimed to find reliable predictive biomarkers of drug combination sensitivity. Using RNA sequencing, we found that abnormal PI3K/Akt pathway activation plays a central role in mediating resistance to the AG regimen. Subsequently, through internal and external verification of randomly selected AG-resistant patient-derived organoid (PDO) and PDO xenograft models, we discovered for the first time that the classic anti-inflammatory drug sulindac K-80003, an inhibitor of the PI3K/Akt pathway that we focused on, promoted sensitization in half (14/28) of AG-resistant pancreatic ductal adenocarcinoma cases. Through RNA-sequencing, multiplex immunofluorescent staining, and immunohistochemistry experiments, we identified cFAM124A as a novel biomarker through which sulindac K-80003 promotes AG sensitization. Its role as a sensitization marker is explained via the following mechanism: cFAM124A enhances both the mRNA expression of cathepsin L and the activity of the cathepsin L enzyme. This dual effect stimulates the cleavage of RXR alpha, leading to large amounts of truncated RXR alpha, which serves as a direct target of K-80003. Consequently, this process results in the pathological activation of the PI3K/Akt pathway. In summary, our study provides a new treatment strategy and novel biological target for patients with drug-resistant pancreatic cancer.
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| GB/T 7714 | Xie, Cheng-Ke , Liao, Cheng-Yu , Lin, Hong-Yi et al. Sulindac (K-80003) with nab-paclitaxel and gemcitabine overcomes drug-resistant pancreatic cancer [J]. | MOLECULAR CANCER , 2024 , 23 (1) . |
| MLA | Xie, Cheng-Ke et al. "Sulindac (K-80003) with nab-paclitaxel and gemcitabine overcomes drug-resistant pancreatic cancer" . | MOLECULAR CANCER 23 . 1 (2024) . |
| APA | Xie, Cheng-Ke , Liao, Cheng-Yu , Lin, Hong-Yi , Wu, Yong-Ding , Lu, Feng-Chun , Huang, Xiao-Xiao et al. Sulindac (K-80003) with nab-paclitaxel and gemcitabine overcomes drug-resistant pancreatic cancer . | MOLECULAR CANCER , 2024 , 23 (1) . |
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Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with dismal prognosis due to distant metastasis, even in the early stage. Using RNA sequencing and multiplex immunofluorescence, here we find elevated expression of mixed lineage kinase domain-like pseudo-kinase (MLKL) and enhanced necroptosis pathway in PDAC from early liver metastasis T-stage (T1M1) patients comparing with non-metastatic (T1M0) patients. Mechanistically, MLKL-driven necroptosis recruits macrophages, enhances the tumor CD47 'don't eat me' signal, and induces macrophage extracellular traps (MET) formation for CXCL8 activation. CXCL8 further initiates epithelial-mesenchymal transition (EMT) and upregulates ICAM-1 expression to promote endothelial adhesion. METs also degrades extracellular matrix, that eventually supports PDAC liver metastasis. Meanwhile, targeting necroptosis and CD47 reduces liver metastasis in vivo. Our study thus reveals that necroptosis facilitates PDAC metastasis by evading immune surveillance, and also suggest that CD47 blockade, combined with MLKL inhibitor GW806742X, may be a promising neoadjuvant immunotherapy for overcoming the T1M1 dilemma and reviving the opportunity for radical surgery. Early-stage liver metastasis of pancreatic ductal adenocarcinoma (PDAC) makes radical surgery not efficacious. Here, the authors show that MLKL-driven necroptosis contributes to PDAC early-stage metastasis by inducing tumour CD47 upregulation and macrophage extracellular traps formation.
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| GB/T 7714 | Liao, Cheng-Yu , Li, Ge , Kang, Feng-Ping et al. Necroptosis enhances 'don't eat me' signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis [J]. | NATURE COMMUNICATIONS , 2024 , 15 (1) . |
| MLA | Liao, Cheng-Yu et al. "Necroptosis enhances 'don't eat me' signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis" . | NATURE COMMUNICATIONS 15 . 1 (2024) . |
| APA | Liao, Cheng-Yu , Li, Ge , Kang, Feng-Ping , Lin, Cai-Feng , Xie, Cheng-Ke , Wu, Yong-Ding et al. Necroptosis enhances 'don't eat me' signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis . | NATURE COMMUNICATIONS , 2024 , 15 (1) . |
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本发明公开了一种可规模化生产具有活性的DNA聚合酶的方法。所述方法包括以下步骤：1)将携带有目的基因的菌种划线于带氨苄抗性的LB平板上，挑取单菌落培养后作为种子液；2)配置高密度发酵培养基，加入发酵罐中；3)将种子液转接到步骤2)的发酵罐中进行培养；4)当培养至溶氧下降至30%以下时，开始加入补料培养基，控制溶氧为30％以上；5)当培养至细菌菌体湿重距最大菌体湿重4g/L时，一次性加入IPTG诱导，使IPTG终浓度为1±0.1 mM；6)达到最佳诱导时长后停止发酵，放罐，获取菌体。本发明提高了目标产物的发酵稳定性，并且减少了包涵体的产生，可实现规模化生产DNA聚合酶。
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| GB/T 7714 | 陈鲤群 , 高上 , 袁智涛 et al. 一种可规模化生产具有活性的DNA聚合酶的方法 : CN202210959921.5[P]. | 2022-08-11 00:00:00 . |
| MLA | 陈鲤群 et al. "一种可规模化生产具有活性的DNA聚合酶的方法" : CN202210959921.5. | 2022-08-11 00:00:00 . |
| APA | 陈鲤群 , 高上 , 袁智涛 , 王涛 , 姜文倩 , 林峻 . 一种可规模化生产具有活性的DNA聚合酶的方法 : CN202210959921.5. | 2022-08-11 00:00:00 . |
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Glioma stem cells (GSCs) are thought to be responsible for the initiation and progression of glioblastoma (GBM). GBM presents highly invasive growth with a very high recurrence rate, so it has become a clinical problem to be solved urgently. RNAseq demonstrates that thrombospondin 1 (THBS1) acts not only in the angiogenic core of glioma but also with a high degree of invasiveness and infiltration. Nevertheless, defects in the signaling pathway research lead to a poor prognosis in glioma patients. To investigate the relevant molecular mechanism and signal pathway of glioma stem cell behavior mediated by THBS1, U251 astroglioma cells and GSCs were taken as model cells for in vitro experiments. The biological effects of THBS1 on glioma proliferation, migration, and adhesion were evaluated using Cell Counting Kit-8(CCK8) assays, EdU incorporation assays, migration assays, Transwell assays, Western blotting, and RNAseq. We found that the knockout of the THBS1 gene by CRISPR/Cas9 promoted proliferation and migration in U251 cells and GSCs, as well as influencing cell cycle progression by regulating the TNF/MAPK/NF-kappa B and TGF-beta/Smad signaling pathways. Moreover, U251 cells and GSCs showed different re-sponses to THBS1 knockout, suggesting specific and potential targets for GSCs in signaling pathways mediated by THBS1.
Keyword ：
Glioma stem cells Glioma stem cells MAPK MAPK Proliferation Proliferation ? signaling pathways ? signaling pathways TGF TGF Thrombospondin 1 Thrombospondin 1 TNF TNF TRAF2 TRAF2
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| GB/T 7714 | Chen, Liqun , Fang, Wei , Chen, Weizhi et al. Deciphering the molecular mechanism of the THBS1 gene in the TNF signaling axis in glioma stem cells [J]. | CELLULAR SIGNALLING , 2023 , 106 . |
| MLA | Chen, Liqun et al. "Deciphering the molecular mechanism of the THBS1 gene in the TNF signaling axis in glioma stem cells" . | CELLULAR SIGNALLING 106 (2023) . |
| APA | Chen, Liqun , Fang, Wei , Chen, Weizhi , Wei, Yiliu , Ding, Jinwang , Li, Jiafeng et al. Deciphering the molecular mechanism of the THBS1 gene in the TNF signaling axis in glioma stem cells . | CELLULAR SIGNALLING , 2023 , 106 . |
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As the market size of the cosmetics industry increases, the safety and effectiveness of new products face higher requirements. The marine environment selects for species of micro-organisms with metabolic pathways and adaptation mechanisms different from those of terrestrial organisms, resulting in their natural products exhibiting unique structures, high diversity, and significant biological activities. Natural products are usually safe and non-polluting. Therefore, considerable effort has been devoted to searching for cosmetic ingredients that are effective, safe, and natural for marine micro-organisms. However, marine micro-organisms can be difficult, or impossible, to culture because of their special environmental requirements. Metagenomics technology can help to solve this problem. Moreover, using marine species to produce more green and environmentally friendly products through biotransformation has become a new choice for cosmetic manufacturers. In this study, the natural products of marine micro-organisms are reviewed and evaluated with respect to various cosmetic applications.
Keyword ：
biotransformation biotransformation cosmetic applications cosmetic applications marine microbes marine microbes metagenomic technology metagenomic technology natural products natural products
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| GB/T 7714 | Ding, Jinwang , Wu, Baochuan , Chen, Liqun . Application of Marine Microbial Natural Products in Cosmetics [J]. | FRONTIERS IN MICROBIOLOGY , 2022 , 13 . |
| MLA | Ding, Jinwang et al. "Application of Marine Microbial Natural Products in Cosmetics" . | FRONTIERS IN MICROBIOLOGY 13 (2022) . |
| APA | Ding, Jinwang , Wu, Baochuan , Chen, Liqun . Application of Marine Microbial Natural Products in Cosmetics . | FRONTIERS IN MICROBIOLOGY , 2022 , 13 . |
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Tumor hypoxia is a great physiological barrier for tumor treatment. The development of efficient detection and treatment methods for tumor hypoxia has great scientific and clinical significance. In this work, we investigated the potential of magnetotactic bacteria AMB-1 for magnetic resonance imaging (MRI)-guided magnetic hyperthermia treatment of hypoxic tumors. Our investigations reveal that AMB-1 bacteria can selectively migrate to the hypoxic regions of solid tumors due to their anaerobic characteristics, showing active deep tumor penetrability. Moreover, AMB-1 bacteria exhibit high MRI contrast and magnetic heating performances because of the excellent magnetic performance of their magnetosomes. In vivo studies demonstrate that AMB-1 can not only generate T-2-weighted contrast signals in tumor tissue, but also efficiently ablate hypoxic solid tumors through the magnetic hyperthermia effect. We believe that this novel microbial therapy can be a potential weapon for hypoxic tumor treatment.
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| GB/T 7714 | Chen, Xin , Lai, Liwen , Li, Xiang et al. Magnetotactic bacteria AMB-1 with active deep tumor penetrability for magnetic hyperthermia of hypoxic tumors [J]. | BIOMATERIALS SCIENCE , 2022 , 10 (22) : 6510-6516 . |
| MLA | Chen, Xin et al. "Magnetotactic bacteria AMB-1 with active deep tumor penetrability for magnetic hyperthermia of hypoxic tumors" . | BIOMATERIALS SCIENCE 10 . 22 (2022) : 6510-6516 . |
| APA | Chen, Xin , Lai, Liwen , Li, Xiang , Cheng, Xintong , Shan, Xinxin , Liu, Xiangqing et al. Magnetotactic bacteria AMB-1 with active deep tumor penetrability for magnetic hyperthermia of hypoxic tumors . | BIOMATERIALS SCIENCE , 2022 , 10 (22) , 6510-6516 . |
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In the long process of human evolution, the Intestinal Bacteria has become intimately related to human health, producing many metabolites in the intestines that can affect cardiovascular disease. Today, the incidence of cardiovascular disease is rising, its treatment is becoming increasingly important, and new therapeutic targets are needed. Here we describe the effects of trimethylamine oxide (TMAO), lipid metabolism, phenolic compounds, indole sulfate (IS), oleuropein (OL), and hydroxytyrosol (HT) on atherosclerosis, heart failure, hypertension, and other cardiovascular diseases, as well as their mechanism of action. This study provides new ideas, new methods, and new directions for the treatment of cardiovascular disease.
Keyword ：
cardiovascular disease cardiovascular disease Intestinal bacteria Intestinal bacteria mechanism of action mechanism of action metabolic products metabolic products
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| GB/T 7714 | Zhao, Yiyi , Chen, Liqun . Effects of intestinal bacteria on cardiovascular disease [J]. | BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS , 2022 . |
| MLA | Zhao, Yiyi et al. "Effects of intestinal bacteria on cardiovascular disease" . | BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS (2022) . |
| APA | Zhao, Yiyi , Chen, Liqun . Effects of intestinal bacteria on cardiovascular disease . | BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS , 2022 . |
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The Nuclear receptor 4A (NR4A) subfamily, which belongs to the nuclear receptor (NR) superfamily, has three members: NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1). They are gene regulators with broad involvement in various signaling pathways and human disease responses, including autophagy. Here, we provide a concise overview of the current understanding of the role of the NR4A subfamily members in human diseases and review the research into their regulation of cell autophagy. A deeper understanding of these mechanisms has potential to improve drug development processes and disease therapy.
Keyword ：
Autophagy Autophagy Human disease Human disease Nor1 Nor1 NR4A family NR4A family Nur77 Nur77 Nurr1 Nurr1
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| GB/T 7714 | Chen, Liqun , Fan, Fengtian , Wu, Lingjuan et al. The nuclear receptor 4A family members: mediators in human disease and autophagy [J]. | CELLULAR & MOLECULAR BIOLOGY LETTERS , 2020 , 25 (1) . |
| MLA | Chen, Liqun et al. "The nuclear receptor 4A family members: mediators in human disease and autophagy" . | CELLULAR & MOLECULAR BIOLOGY LETTERS 25 . 1 (2020) . |
| APA | Chen, Liqun , Fan, Fengtian , Wu, Lingjuan , Zhao, Yiyi . The nuclear receptor 4A family members: mediators in human disease and autophagy . | CELLULAR & MOLECULAR BIOLOGY LETTERS , 2020 , 25 (1) . |
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