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学者姓名：宋继彬
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Abstract ：
The hypoxic microenvironment and radioresistance of tumor cells, as well as the delay in efficacy evaluation, significantly limit the effect of clinical radiotherapy. Therefore, developing effective radiosensitizers with monitoring of tumor response is of great significance for precise radiotherapy. Herein, a novel radiosensitizer (term as: SCuFs) is developed, consisting of traditional Chinese medicine (TCM) compounds salidroside, Cu2+, and hydroxyl radical (center dot OH) activated second near-infrared window fluorescence (NIR-II FL) molecules, which make the radiosensitization effect and boosted chemodynamic therapy (CDT) efficacy. The overexpressed glutathione in the tumor induces the SCuFs dissociation, allowing deep penetration of the drug to the whole tumor region. After X-ray irradiation, salidroside inhibits the Nuclear factor erythroid 2-like 2 (Nrf2)protein expression and blocks cells in the G2/M phase with the highest radiosensitivity, which amplifies the reactive oxygen species (ROS) generation to exacerbate DNA damage, thus achieving radiosensitization. Meanwhile, the upregulated ROS provides sufficient chemical fuel for Cu+-mediated CDT to produce more center dot OH. NIR-II FL imaging can monitor the center dot OH changes during the therapy process, confirming the radiosensitization effect and CDT process related to center dot OH. This study not only achieves effective radiosensitization and cascaded ROS-mediated CDT efficacy, but also provides a useful tool for monitoring therapeutic efficacy, showing great prospects for clinical application.
Keyword ：
activatable probe activatable probe in vivo bioimaging in vivo bioimaging NIR-II fluorescence NIR-II fluorescence radiotherapy radiotherapy self-assembly self-assembly
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| GB/T 7714 | Li, Qingqing , Chen, Qing , Xiao, Shenggan et al. A Salidroside-Based Radiosensitizer Regulates the Nrf2/ROS Pathway for X-Ray Activated Synergistic Cancer Precise Therapy [J]. | ADVANCED MATERIALS , 2025 , 37 (24) . |
| MLA | Li, Qingqing et al. "A Salidroside-Based Radiosensitizer Regulates the Nrf2/ROS Pathway for X-Ray Activated Synergistic Cancer Precise Therapy" . | ADVANCED MATERIALS 37 . 24 (2025) . |
| APA | Li, Qingqing , Chen, Qing , Xiao, Shenggan , Wang, Shuhan , Ge, Xiaoguang , Wang, Qian et al. A Salidroside-Based Radiosensitizer Regulates the Nrf2/ROS Pathway for X-Ray Activated Synergistic Cancer Precise Therapy . | ADVANCED MATERIALS , 2025 , 37 (24) . |
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Chemiluminescence (CL) is a self-illuminating phenomenon fueled by chemical energy instead of extra excited light, which features superiority in sensitivity, signal-to-background ratios, and imaging depth. Strategies to synthesize a CL emission unimolecular skeleton in the second near-infrared window (NIR-II) and a unimolecular probe with direct duplex NIR-II [CL/fluorescence (FL)] emission are lacking. Here, we employ modular synthesis routes to construct a series of directly activated NIR-II CL emission unimolecular probes with a maximum emission wavelength of up to 1060 nm, and use them for real-time and continuous detection of the superoxide anion generated in acetaminophen induced liver injury in a female mice model under both NIR-II CL and NIR-II FL imaging channels. Thus, this study establishes a directly activatable NIR-II CL emission unimolecular skeleton, validating the scalability of this duplex NIR-II CL/FL imaging platform in bioactive molecule detection and disease diagnosis.
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| GB/T 7714 | Chen, Zhongxiang , Li, Qian , Wu, Ying et al. Molecular Engineering of Direct Activated NIR-II Chemiluminescence Platform for In Vivo Chemiluminescence-fluorescence Duplex Imaging [J]. | NATURE COMMUNICATIONS , 2025 , 16 (1) . |
| MLA | Chen, Zhongxiang et al. "Molecular Engineering of Direct Activated NIR-II Chemiluminescence Platform for In Vivo Chemiluminescence-fluorescence Duplex Imaging" . | NATURE COMMUNICATIONS 16 . 1 (2025) . |
| APA | Chen, Zhongxiang , Li, Qian , Wu, Ying , Liu, Jianyong , Liu, Luntao , Su, Lichao et al. Molecular Engineering of Direct Activated NIR-II Chemiluminescence Platform for In Vivo Chemiluminescence-fluorescence Duplex Imaging . | NATURE COMMUNICATIONS , 2025 , 16 (1) . |
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In the field of quantum dot (QD)-based micro-light-emitting diode (mu LED) full-color display technology, achieving high color conversion efficiency (CCE) is one of the key performance indicators. In this work, a mu LED architecture is presented that incorporates an optimized nanorod array, with QDs and nanogapped gold nanoparticles (AuNNPs) embedded in the inter-rod gaps. By harnessing non-radiative energy transfer (NRET) and localized surface plasmon resonance (LSPR), the absorption and utilization of quantum well (QW) energy by the QDs are significantly enhanced. To ensure efficient current spreading and uniform light emission, graphene is employed as a transparent conductive layer to interconnect the nanorods. As graphene can transfer photogenerated carriers to the QDs, enhancing their quantum yield, it is also introduced as an intermediate insertion layer and support layer, allowing the integration of a second layer of QDs and AuNNPs on the light-emitting surface. This design maintains the electrical performance of the nanorod mu LED while achieving ultra-high CCE. Experimental results demonstrate that the proposed mu LED with nanorod structures and AuNNPs achieves a maximum CCE of 94%, representing a 102% improvement compared to conventional planar mu LEDs. These findings offer promising insights for advancing high-performance, full-color mu LED display technologies through nanoscale engineering.
Keyword ：
graphene graphene local surface plasmon local surface plasmon micro-LED micro-LED non-radiative energy non-radiative energy quantum dot quantum dot
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| GB/T 7714 | Fang, Aoqi , Li, Qingqing , Liu, Jixin et al. Ultra-High Quantum Dot Color Conversion in Graphene-Connected Nanorod Micro-LEDs via Non-Radiative Energy Transfer and Localized Surface Plasmon Resonance [J]. | LASER & PHOTONICS REVIEWS , 2025 . |
| MLA | Fang, Aoqi et al. "Ultra-High Quantum Dot Color Conversion in Graphene-Connected Nanorod Micro-LEDs via Non-Radiative Energy Transfer and Localized Surface Plasmon Resonance" . | LASER & PHOTONICS REVIEWS (2025) . |
| APA | Fang, Aoqi , Li, Qingqing , Liu, Jixin , Du, Zaifa , Tang, Penghao , Xu, Hao et al. Ultra-High Quantum Dot Color Conversion in Graphene-Connected Nanorod Micro-LEDs via Non-Radiative Energy Transfer and Localized Surface Plasmon Resonance . | LASER & PHOTONICS REVIEWS , 2025 . |
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Stimuli-triggered release and alleviating resistance of iridium(III)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy. Herein, a doxorubicin@iridium-transferrin (DOX@IrTF) nanovesicle was synthesized by carboxylated-transferrin (TF) and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium (QA) groups and disulfide bonds. The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species (ROS), while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione (GSH); simultaneously, modification of TF improved recognition and endocytosis of the nanovesicle for tumor cells. Based on in -vitro results, a controlled-release behavior of DOX upon a dualresponsiveness of GSH and near-infrared ray (NIR) irradiation was presented, along with high-efficiency generation of ROS. After an intravenous injection, the nanovesicle was targeted at tumor sites, realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations. Overall, newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery, dual -stimuli responsive release, synergistic therapy strategy, and real -time monitoring. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Amphiphilic iridium complex Amphiphilic iridium complex NIR/GSH dual-responsiveness NIR/GSH dual-responsiveness Photoacoustic imaging Photoacoustic imaging Synergistic tumor therapy Synergistic tumor therapy Transferrin targeting Transferrin targeting
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| GB/T 7714 | Guo, Jinyu , Lin, Yandai , He, Shaohua et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
| MLA | Guo, Jinyu et al. "Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy" . | CHINESE CHEMICAL LETTERS 35 . 9 (2024) . |
| APA | Guo, Jinyu , Lin, Yandai , He, Shaohua , Chen, Yueqing , Li, Fenglu , Ruan, Renjie et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy . | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
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Abstract ：
Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites re-mains challengeable for clinical hepatoma therapy.Herein,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was synthesized by carboxylated-transferrin(TF)and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium(QA)groups and disulfide bonds.The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species(ROS),while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glu-tathione(GSH);simultaneously,modification of TF improved recognition and endocytosis of the nanovesi-cle for tumor cells.Based on in-vitro results,a controlled-release behavior of DOX upon a dual-responsiveness of GSH and near-infrared ray(NIR)irradiation was presented,along with high-efficiency generation of ROS.After an intravenous injection,the nanovesicle was targeted at tumor sites,realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations.Overall,newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcuta-neous hepatocellular carcinoma therapy due to integrations of targeting delivery,dual-stimuli responsive release,synergistic therapy strategy,and real-time monitoring.
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| GB/T 7714 | Jinyu Guo , Yandai Lin , Shaohua He et al. Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy [J]. | 中国化学快报（英文版） , 2024 , 35 (9) : 296-302 . |
| MLA | Jinyu Guo et al. "Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy" . | 中国化学快报（英文版） 35 . 9 (2024) : 296-302 . |
| APA | Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan et al. Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy . | 中国化学快报（英文版） , 2024 , 35 (9) , 296-302 . |
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Large osseous void, postsurgical neoplastic recurrence, and slow bone-cartilage repair rate raise an imperative need to develop functional scaffold in clinical osteosarcoma treatment. Herein, a bionic bilayer scaffold constituting croconaine dye-polyethylene glycol@sodium alginate hydrogel and poly(L-lactide)/hydroxyapatite polymer matrix is fabricated to simultaneously achieve a highly efficient killing of osteosarcoma and an accelerated osteochondral regeneration. First, biomimetic osteochondral structure along with adequate interfacial interaction of the bilayer scaffold provide a structural reinforcement for transverse osseointegration and osteochondral regeneration, as evidenced by upregulated specific expressions of collagen type-I, osteopontin, and runt-related transcription factor 2. Meanwhile, thermal ablation of the synthesized nanoparticles and mitochondrial dysfunction caused by continuously released hydroxyapatite induce residual tumor necrosis synergistically. To validate the capabilities of inhibiting tumor growth and promoting osteochondral regeneration of our proposed scaffold, a novel orthotopic osteosarcoma model simulating clinical treatment scenarios of bone tumors is established on rats. Based on amounts of in vitro and in vivo results, an effective killing of osteosarcoma and a suitable osteal-microenvironment modulation of such bionic bilayer composite scaffold are achieved, which provides insightful implications for photonic hyperthermia therapy against osteosarcoma and following osseous tissue regeneration.
Keyword ：
bilayer scaffold bilayer scaffold biomaterials biomaterials orthotopicosteosarcoma orthotopicosteosarcoma osteochondral regeneration osteochondral regeneration photonic hyperthermiatherapy photonic hyperthermiatherapy
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| GB/T 7714 | Gong, Chenchi , Wang, Jun , Tang, Faqiang et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) : 8538-8553 . |
| MLA | Gong, Chenchi et al. "Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration" . | ACS APPLIED MATERIALS & INTERFACES 16 . 7 (2024) : 8538-8553 . |
| APA | Gong, Chenchi , Wang, Jun , Tang, Faqiang , Tong, Dongmei , Wang, Ziyi , Zhou, Zijie et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) , 8538-8553 . |
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The external quantum efficiency (EQE) enhancement of different sized GaN micro-light-emitting diodes (mu LEDs) by using localized surface plasmons (LSPs) have been studied. Silver nanoparticles (Ag NPs) are attached to the sidewalls of mu LEDs by spin-coating so as to be effectively coupled with the multiple quantum well (MQW) of mu LEDs and generate the LSPs. In the mu LEDs with 20 x 20 mu m2 large mesas, the LSPs can effectively inhibit the efficiency droop. Compared to the mu LED samples without the LSPs coupling, the EQE has been enhanced by about 8% at a high current density of 20,000 A/cm2. This work confirms the effectiveness of the LSPs technology in improving the mu LED performances, which is originally practiced only on the basal faces of conventional LEDs.
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| GB/T 7714 | Du, Zaifa , Sun, Jie , Feng, Hongjuan et al. Efficiency enhancement of micro-light-emitting diode with shrinking size by localized surface plasmons coupling [J]. | APPLIED PHYSICS B-LASERS AND OPTICS , 2024 , 130 (3) . |
| MLA | Du, Zaifa et al. "Efficiency enhancement of micro-light-emitting diode with shrinking size by localized surface plasmons coupling" . | APPLIED PHYSICS B-LASERS AND OPTICS 130 . 3 (2024) . |
| APA | Du, Zaifa , Sun, Jie , Feng, Hongjuan , Tang, Penghao , Guo, Weiling , Han, Kai et al. Efficiency enhancement of micro-light-emitting diode with shrinking size by localized surface plasmons coupling . | APPLIED PHYSICS B-LASERS AND OPTICS , 2024 , 130 (3) . |
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The controllable assembly of nanoparticles significantly improves their biological effects in vivo. However, it is difficult to realize the assembly regulation of nanomaterials under complex physiological conditions. Herein, endogenous glutathione (GSH)-triggered vesicles with spatiotemporally confined aggregation of gold nanogapped nanoparticles (AuNNPs) within vesicles were developed. These vesicles had excellent photoacoustic (PA) imaging capability in the near-infrared second window (NIR-II) for precise localization of deep tumors, measuring tumor volume, and making deep tumors more sensitive to radiotherapy and chemodynamic therapy (CDT). The vesicles were prepared via self-assembly of MnO2-coated AuNNPs that were functionalized by phosphate-polystyrene and bovine serum albumin (AuNNP@MnO2 Ve@BSA). The MnO2 shell was etched when AuNNP@MnO2 Ve@BSA vesicle was exposed to GSH, the gap between intra-vesicular AuNNP@MnO2 NPs was reduced. This significantly enhanced the plasmonic coupling effect be-tween AuNNP@MnO2 NPs, giving it excellent NIR-II PA imaging capability, and thus can be used to delineate the boundary and volume of deep-seated tumors. Meanwhile, the Mn2+-mediated CDT released after the etching of the MnO2 shell interacted with GSH-responsive AuNNP@MnO2 Ve@BSA and significantly in-hibited tumor growth due to enhanced radiosensitization effect. This unique strategy provides new per-spectives and methods for designing and applying biomedical nanomaterials.& COPY; 2023 Published by Elsevier Ltd.
Keyword ：
NIR-II NIR-II Photoacoustic imaging Photoacoustic imaging Radiosensitizer Radiosensitizer Self-assembly Self-assembly X-ray X-ray
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| GB/T 7714 | Su, Lichao , Tang, Huaiding , Liao, Naishun et al. Spatiotemporally confined assembly of radiosensitizers for synergistic radio-chemodynamic therapy on deep tumor of rabbit [J]. | NANO TODAY , 2023 , 50 . |
| MLA | Su, Lichao et al. "Spatiotemporally confined assembly of radiosensitizers for synergistic radio-chemodynamic therapy on deep tumor of rabbit" . | NANO TODAY 50 (2023) . |
| APA | Su, Lichao , Tang, Huaiding , Liao, Naishun , Chen, Zhongxiang , Li, Hang , Ge, Xiaoguang et al. Spatiotemporally confined assembly of radiosensitizers for synergistic radio-chemodynamic therapy on deep tumor of rabbit . | NANO TODAY , 2023 , 50 . |
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Radiotherapy (RT) is an effective and widely applied cancer treatment strategy in clinic. However, it usually suffers from radioresistance of tumor cells and severs side effects of excessive radiation dose. Therefore, it is highly significant to improve radiotherapeutic performance and monitor real-time tumor response, achieving precise and safe RT. Herein, an X-ray responsive radio-pharmaceutical molecule containing chemical radiosensitizers of diselenide and nitroimidazole (BBT-IR/Se-MN) is reported. BBT-IR/Se-MN exhibits enhanced radiotherapeutic effect via a multifaceted mechanisms and self-monitoring ROS levels in tumors during RT. Under X-ray irradiation, the diselenide produces high levels of ROS, leading to enhanced DNA damage of cancer cell. Afterwards, the nitroimidazole in the molecule inhibits the damaged DNA repair, offering a synergetic radiosensitization effect of cancer. Moreover, the probe shows low and high NIR-II fluorescence ratios in the absence and presence of ROS, which is suitable for precise and quantitative monitoring of ROS during sensitized RT. The integrated system is successfully applied for radiosensitization and the early prediction of in vitro and in vivo RT efficacy.
Keyword ：
Activatable Probe Activatable Probe Biosensor Biosensor NIR-II Fluorescence Imaging NIR-II Fluorescence Imaging Radiotherapy Radiotherapy X-Ray X-Ray
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| GB/T 7714 | Ge, Xiaoguang , Su, Lichao , Chen, Zhongxiang et al. A Radio-Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2023 , 62 (29) . |
| MLA | Ge, Xiaoguang et al. "A Radio-Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 62 . 29 (2023) . |
| APA | Ge, Xiaoguang , Su, Lichao , Chen, Zhongxiang , Zhu, Kang , Zhang, Xuan , Wu, Ying et al. A Radio-Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2023 , 62 (29) . |
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Surface-enhanced Raman scattering (SERS) is a feasible and ultra-sensitive method for biomedical imaging and disease diagnosis. SERS is widely applied to in vivo imaging due to the development of functional nanoparticles encoded by Raman active molecules (SERS nanoprobes) and improvements in instruments. Herein, the recent developments in SERS active materials and their in vivo imaging and biosensing applications are overviewed. Various SERS substrates that have been successfully used for in vivo imaging are described. Then, the applications of SERS imaging in cancer detection and in vivo intraoperative guidance are summarized. The role of highly sensitive SERS biosensors in guiding the detection and prevention of diseases is discussed in detail. Moreover, its role in the identification and resection of microtumors and as a diagnostic and therapeutic platform is also reviewed. Finally, the progress and challenges associated with SERS active materials, equipment, and clinical translation are described. The present evidence suggests that SERS could be applied in clinical practice in the future.
Keyword ：
biosensing biosensing diagnosis diagnosis Raman mapping Raman mapping self-assembly self-assembly surface-enhanced Raman scattering surface-enhanced Raman scattering
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| GB/T 7714 | Li, Qingqing , Huo, Hongqi , Wu, Ying et al. Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing [J]. | ADVANCED SCIENCE , 2023 , 10 (8) . |
| MLA | Li, Qingqing et al. "Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing" . | ADVANCED SCIENCE 10 . 8 (2023) . |
| APA | Li, Qingqing , Huo, Hongqi , Wu, Ying , Chen, Lanlan , Su, Lichao , Zhang, Xuan et al. Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing . | ADVANCED SCIENCE , 2023 , 10 (8) . |
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