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学者姓名：袁耀锋
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Abstract ：
研究生教育是高等教育的最高层次，是衡量一个国家高等教育竞争力的关键标志，是拔尖创新人才自主培养的主渠道。为了提高人才培养质量，在“以学生为中心，注重科学思维培养，注重科研能力培养以及注重国际视野培养”的教学思想指导下，针对有机结构分析课程教学过程中存在的难点问题，从“教学理念的国际化、教学内容的国际化、教学团队的国际化、教学方法的国际化”等方面进行创新教学实践，取得了一系列成果，有效地提升了学生的科研水平，对于创新型人才的培养起到了积极的推动作用。
Keyword ：
国际化视野 国际化视野 学生为中心 学生为中心 有机结构分析 有机结构分析 研究生教学 研究生教学
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| GB/T 7714 | 袁耀锋 , 叶克印 , 徐春发 et al. 在研究生课程的教学中注重国际视野的培养——以“有机结构分析”课程为例 [J]. | 大学化学 , 2024 , 39 (06) : 145-150 . |
| MLA | 袁耀锋 et al. "在研究生课程的教学中注重国际视野的培养——以“有机结构分析”课程为例" . | 大学化学 39 . 06 (2024) : 145-150 . |
| APA | 袁耀锋 , 叶克印 , 徐春发 , 晏宏 , 李远明 . 在研究生课程的教学中注重国际视野的培养——以“有机结构分析”课程为例 . | 大学化学 , 2024 , 39 (06) , 145-150 . |
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Abstract ：
芳香亲核取代反应被有机化学家广泛地用于有机化合物的合成，是最重要的合成反应之一。教材中对于该反应机理的介绍为分步过程，但是随着研究的深入，通过协同过程的芳香亲核取代反应已经被广泛证实。本文简要回顾了分步进行的芳香亲核取代反应，重点介绍了协同芳香亲核取代反应的几个实例，阐述了反应设计对机理研究的重要性。通过将科研成果融入教学过程，有助于进一步加深对芳香亲核取代反应的理解。
Keyword ：
分步 分步 协同 协同 反应机理 反应机理 芳香亲核取代反应 芳香亲核取代反应
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| GB/T 7714 | 林文涛 , 王文峰 , 袁耀锋 et al. 协同芳香亲核取代反应 [J]. | 大学化学 , 2024 , 39 (06) : 226-230 . |
| MLA | 林文涛 et al. "协同芳香亲核取代反应" . | 大学化学 39 . 06 (2024) : 226-230 . |
| APA | 林文涛 , 王文峰 , 袁耀锋 , 徐春发 . 协同芳香亲核取代反应 . | 大学化学 , 2024 , 39 (06) , 226-230 . |
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Abstract ：
研究生教育是高等教育的最高层次,是衡量一个国家高等教育竞争力的关键标志,是拔尖创新人才自主培养的主渠道.为了提高人才培养质量,在"以学生为中心,注重科学思维培养,注重科研能力培养以及注重国际视野培养"的教学思想指导下,针对有机结构分析课程教学过程中存在的难点问题,从"教学理念的国际化、教学内容的国际化、教学团队的国际化、教学方法的国际化"等方面进行创新教学实践,取得了一系列成果,有效地提升了学生的科研水平,对于创新型人才的培养起到了积极的推动作用.
Keyword ：
国际化视野 国际化视野 学生为中心 学生为中心 有机结构分析 有机结构分析 研究生教学 研究生教学
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| GB/T 7714 | 袁耀锋 , 叶克印 , 徐春发 et al. 在研究生课程的教学中注重国际视野的培养 [J]. | 大学化学 , 2024 , 39 (6) : 145-150 . |
| MLA | 袁耀锋 et al. "在研究生课程的教学中注重国际视野的培养" . | 大学化学 39 . 6 (2024) : 145-150 . |
| APA | 袁耀锋 , 叶克印 , 徐春发 , 晏宏 , 李远明 . 在研究生课程的教学中注重国际视野的培养 . | 大学化学 , 2024 , 39 (6) , 145-150 . |
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Abstract ：
有机电化学合成技术以电子代替传统有机反应的氧化还原剂，具有经济高效、环境友好、可持续发展等特点。通过将电化学合成苯并噁噻嗪二氧化物的科研成果转化为本科生实验，可以让学生建立“绿色化学”的理念，了解有机电化学合成技术对服务人类生态文明、国家需求和维护人民生命健康的重要意义，从而提高学生的专业认同感和社会责任感。通过将课程思政渗透到实验教学的全过程，全方位培养学生的科学思维、科学能力和科学素养。
Keyword ：
实验教学 实验教学 电化学合成 电化学合成 课程思政 课程思政
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| GB/T 7714 | 林彩霞 , 施兆江 , 余意 et al. 电化学合成苯并噁噻嗪二氧化物实验的课程思政设计 [J]. | 大学化学 , 2024 , 39 (02) : 61-66 . |
| MLA | 林彩霞 et al. "电化学合成苯并噁噻嗪二氧化物实验的课程思政设计" . | 大学化学 39 . 02 (2024) : 61-66 . |
| APA | 林彩霞 , 施兆江 , 余意 , 鄢剑锋 , 叶克印 , 袁耀锋 . 电化学合成苯并噁噻嗪二氧化物实验的课程思政设计 . | 大学化学 , 2024 , 39 (02) , 61-66 . |
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Abstract ：
介绍了一个综合化学实验，涉及二茂铁苯基衍生物的合成、光物理和电化学性质的表征。该实验难度适中，综合运用了多种表征方法和测试手段，将大学基础化学理论、基本实验技能与金属有机领域的学术研究相结合。采用逆合成分析法设计了“一锅法”水相合成路线，旨在帮助学生树立绿色化学的概念以及培养可持续发展的思想。实验运用了紫外-可见吸收光谱和电化学方法对目标化合物的光物理和电化学性质进行研究，并结合量化计算手段详细比较了给电子基团和吸电子基团对分子电荷分布带来的影响。通过以科研反哺教学的模式，本实验不仅使学生掌握了基本的科研训练，而且培养了他们的综合实验素质。
Keyword ：
二茂铁苯基衍生物 二茂铁苯基衍生物 光物理 光物理 水相合成 水相合成 电化学 电化学 综合化学实验 综合化学实验 量化计算 量化计算
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| GB/T 7714 | 鄢剑锋 , 肖雅婷 , 左鑫 et al. 二茂铁苯基衍生物的综合化学实验设计 [J]. | 大学化学 , 2024 , 39 (04) : 329-337 . |
| MLA | 鄢剑锋 et al. "二茂铁苯基衍生物的综合化学实验设计" . | 大学化学 39 . 04 (2024) : 329-337 . |
| APA | 鄢剑锋 , 肖雅婷 , 左鑫 , 林彩霞 , 袁耀锋 . 二茂铁苯基衍生物的综合化学实验设计 . | 大学化学 , 2024 , 39 (04) , 329-337 . |
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Both synthesis and DFT calculation of [3 + 2] cycloaddition reaction (32CA) of quinolone-5,8-dione with 1,3dipole CF3CHN2 are studied. The focus of this work is to study the orbital interactions of this reaction by using molecular orbital tracing (MOT) method. MOT result shows that both quinolone-5,8-dione and CF3CHN2 use three electrons occupied molecular orbitals (MOs) to interact with each other, and the evolutive courses of the six molecular orbitals of reactants (initial MOs) to six electrons occupied molecular orbitals of product (final MOs) are given in this work. Three of the six initial MOs can evolve as final MOs directly, but rest of them need to go through media orbitals to complete the evolution. Perhaps the role of the media orbitals is to enable the reaction to proceed concertedly. APT charges analysis and changes of bond lengths during the reaction are also afforded in this work, and the result shows that the reaction begins with a nucleophilic attack of CF3CHN2 on quinolone-5,8-dione. Accompanying with the attack, negative charge transfers from CF3CHN2 to a carbon atom of quinolone-5,8-dione, then the carbon atom attacks nitrogen atom of CF3CHN2 to complete the cycloaddition. At last, a mechanism and a diagram of the molecular orbital interactions of the reaction are given.
Keyword ：
[3+2] cycloaddition reaction [3+2] cycloaddition reaction DFT calculation DFT calculation Media orbital Media orbital Molecular orbital tracing Molecular orbital tracing synthesis synthesis
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| GB/T 7714 | Huang, Zhiyong , Lei, Chun , Cheng, Yao et al. A study on the orbital interactions of [3+2] cycloaddition by means of molecular orbital tracing method [J]. | JOURNAL OF MOLECULAR STRUCTURE , 2024 , 1306 . |
| MLA | Huang, Zhiyong et al. "A study on the orbital interactions of [3+2] cycloaddition by means of molecular orbital tracing method" . | JOURNAL OF MOLECULAR STRUCTURE 1306 (2024) . |
| APA | Huang, Zhiyong , Lei, Chun , Cheng, Yao , Yuan, Yaofeng , Zhang, Yongfan , Wang, Wenfeng . A study on the orbital interactions of [3+2] cycloaddition by means of molecular orbital tracing method . | JOURNAL OF MOLECULAR STRUCTURE , 2024 , 1306 . |
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The development of efficient and sustainable methods to obtain spirocyclic compounds is of significance as these structures are widely found in pharmaceuticals and agrochemicals. Herein, we disclose an electrochemical dearomative spirocyclization of N-acyl sulfonamides in a continuous-flow cell. The reaction is simple and efficient without external catalysts or supporting electrolytes and could be applied in a decagram-scale synthesis.
Keyword ：
Continuous-flow Continuous-flow Cyclization Cyclization Dearomatization Dearomatization Electrochemistry Electrochemistry Methodology and reactions Methodology and reactions Spirocyclization Spirocyclization Sulfonamides Sulfonamides
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| GB/T 7714 | Liu, Ting , Shi, Zhaojiang , Yuan, Yaofeng et al. Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides in a Continuous-Flow Cell [J]. | CHINESE JOURNAL OF CHEMISTRY , 2024 . |
| MLA | Liu, Ting et al. "Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides in a Continuous-Flow Cell" . | CHINESE JOURNAL OF CHEMISTRY (2024) . |
| APA | Liu, Ting , Shi, Zhaojiang , Yuan, Yaofeng , Lin, Yuqi , Ye, Ke-Yin . Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides in a Continuous-Flow Cell . | CHINESE JOURNAL OF CHEMISTRY , 2024 . |
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Efficient control over several possible reaction pathways of free radicals is the chemical basis of their highly selective transformations. Among various competing reaction pathways, sulfonimidyl radicals generated from the electrolysis of 2-alkynylbenzenesulfonamides undergo cascade migratory or ortho-cyclization cyclization selectively. It is found that the incorporation of an extra 2-methyl substituent biases the selective migration of the acyl- over vinyl-linker of the key spirocyclic cation intermediate and thus serves as an enabling handle to achieve the synthetically interesting yet under-investigated cascade migratory cyclization of spirocyclic cations.
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| GB/T 7714 | Shi, Zhaojiang , Dong, Shicheng , Liu, Ting et al. Electrochemical cascade migratory versus ortho-cyclization of 2-alkynylbenzenesulfonamides [J]. | CHEMICAL SCIENCE , 2024 , 15 (8) : 2827-2832 . |
| MLA | Shi, Zhaojiang et al. "Electrochemical cascade migratory versus ortho-cyclization of 2-alkynylbenzenesulfonamides" . | CHEMICAL SCIENCE 15 . 8 (2024) : 2827-2832 . |
| APA | Shi, Zhaojiang , Dong, Shicheng , Liu, Ting , Wang, Wei-Zhen , Li, Nan , Yuan, Yaofeng et al. Electrochemical cascade migratory versus ortho-cyclization of 2-alkynylbenzenesulfonamides . | CHEMICAL SCIENCE , 2024 , 15 (8) , 2827-2832 . |
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Two o-carborane based tetraphenylethene (TPE) cationic cyclophanes O1·4PF6 and O2·4PF6 were synthesized through an SN2 reaction. Their structures were confirmed both possessing Z-shaped cavities in single crystal analysis. The optical properties of these macrocycles were systematically investigated using UV–vis spectroscopy and fluorescence techniques. It is worth noting that the introduction of a methoxy group to the TPE unit enables the synthesis of a near-infrared-emitting macrocycle O2·4PF6. The recognition behaviors of these two macrocycles towards nucleotides were investigated using various techniques including fluorescence titration, UV–vis titration, and transmission electron microscopy (TEM). Interestingly, these cyclophanes exhibited aggregation-induced emission (AIE) effects in water or under the induction of nucleotides. © 2024
Keyword ：
AIE effect AIE effect Cationic cyclophanes Cationic cyclophanes Nucleotides Nucleotides o-Carborane o-Carborane Tetraphenylethene Tetraphenylethene
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| GB/T 7714 | Chen, R. , Liu, J. , Lin, C. et al. Synthesis and properties of tetraphenylethene cationic cyclophanes based on o-carborane skeleton [J]. | Chinese Chemical Letters , 2024 , 35 (12) . |
| MLA | Chen, R. et al. "Synthesis and properties of tetraphenylethene cationic cyclophanes based on o-carborane skeleton" . | Chinese Chemical Letters 35 . 12 (2024) . |
| APA | Chen, R. , Liu, J. , Lin, C. , Li, Y. , Geng, Y. , Yuan, Y. . Synthesis and properties of tetraphenylethene cationic cyclophanes based on o-carborane skeleton . | Chinese Chemical Letters , 2024 , 35 (12) . |
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Eleven two-carbon tethered artemisinin-isatin hybrids (4a-k) were designed, synthesized, and evaluated for their antiproliferative activity against MCF-7, MDA-MB-231, and MDA-MB-231/ADR breast cancer cell lines, as well as cytotoxicity toward MCF-10A cells in this paper. Among them, the representative hybrid 4a (IC50: 2.49-12.6 mu M) was superior to artemisinin (IC50: 72.4->100 mu M), dihydroartemisinin (IC50: 69.6-89.8 mu M), and Adriamycin (IC50: 4.46->100 mu M) against the three tested breast cancer cell lines. The structure-activity relationship revealed that the length of the alkyl linker between artemisinin and isatin was critical for the activity, so further structural modification could focus on evaluation of the linker. The in silico studies were used to investigate the mechanism of the most promising hybrid 4a. Target prediction, bioinformatics, molecular docking, and molecular dynamics revealed that the most promising hybrid 4a may exert anti-breast cancer activity by acting on multiple targets such as EGFR, PIK3CA, and MAPK8 and thus participating in multiple tumor-related signaling pathways.
Keyword ：
artemisinin artemisinin breast cancer breast cancer drug resistance drug resistance hybrid molecules hybrid molecules in silico study in silico study isatin isatin
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| GB/T 7714 | Wang, Ruo , Huang, Renhong , Yuan, Yaofeng et al. Two-carbon tethered artemisinin-isatin hybrids: design, synthesis, anti-breast cancer potential, and in silico study [J]. | FRONTIERS IN MOLECULAR BIOSCIENCES , 2023 , 10 . |
| MLA | Wang, Ruo et al. "Two-carbon tethered artemisinin-isatin hybrids: design, synthesis, anti-breast cancer potential, and in silico study" . | FRONTIERS IN MOLECULAR BIOSCIENCES 10 (2023) . |
| APA | Wang, Ruo , Huang, Renhong , Yuan, Yaofeng , Wang, Zheng , Shen, Kunwei . Two-carbon tethered artemisinin-isatin hybrids: design, synthesis, anti-breast cancer potential, and in silico study . | FRONTIERS IN MOLECULAR BIOSCIENCES , 2023 , 10 . |
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