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学者姓名：曾华强
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Abstract ：
H-bonded helically folded aromatic foldamers rely on the precise formation of H-bonds between each helicity codon and its neighboring codons to maintain their structure. We report here for the first time that the phenyl group, referred to as a non-helicity codon due to its inability to form H-bonds, does not necessarily disrupt the helical structure. Specifically, we modified our recently reported pyridine-based aquapentamers by sequentially replacing each of the five pyridine residues with a phenyl group, creating a series of five hybrid pentamers. The phenyl groups, unable to form H-bonds with the adjacent N-H bonds of the amides, introduce H-bond defects along the helical backbone. Despite these defects, three out of five pentamers still adopt a helical structure and function as highly selective and ultra-fast abiotic water channels, with the most efficient channel achieving a water transport rate of 1.8 x 109 H2O s-1 per channel-approximately 30% of aquaporin Z's capacity.
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| GB/T 7714 | Cao, Gaiping , Yang, Zihong , Zhao, Huaiqing et al. Superfast and highly selective water transport by hybrid aquapentamers incorporating a non-helicity codon [J]. | ORGANIC CHEMISTRY FRONTIERS , 2025 , 12 (5) : 1603-1611 . |
| MLA | Cao, Gaiping et al. "Superfast and highly selective water transport by hybrid aquapentamers incorporating a non-helicity codon" . | ORGANIC CHEMISTRY FRONTIERS 12 . 5 (2025) : 1603-1611 . |
| APA | Cao, Gaiping , Yang, Zihong , Zhao, Huaiqing , Shen, Jie , Chang, Wenju , Liu, Zhiwei et al. Superfast and highly selective water transport by hybrid aquapentamers incorporating a non-helicity codon . | ORGANIC CHEMISTRY FRONTIERS , 2025 , 12 (5) , 1603-1611 . |
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Abstract ：
Dysregulation of anion transport is implicated in a range of diseases, including congenital myotonia, cystic fibrosis, and hereditary renal lithiasis. While natural anion channels exhibit highly complex and intricate structures, the development of structurally simpler artificial channels holds promise for advancing the understanding of anion transport mechanisms and offering novel therapeutic approaches. Among emerging strategies, the use of side chain-side chain interactions to construct artificial anion channels has shown significant potential, particularly through the application of flexible hydrocarbon side chains to facilitate pore formation. Building on this concept, we introduce a novel scaffold-the dibenzo-12-crown-4 group-which unexpectedly acts as a pore-forming enhancer, rather than a cation transporter. By strengthening side chain-side chain interactions, this group promotes the formation of sizable pores within lipid bilayers, selectively and efficiently transporting anions, rather than cations. Notably, channel A10 exhibits a remarkable high Cl-/K+ selectivity ratio of 17 while showcasing a distinct hierarchy in anion conductivity: ClO4- > I- > NO3- > Br- > Cl-.
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| GB/T 7714 | Fan, Jisen , Xu, Yingxue , Shen, Jie et al. Dibenzo-12-crown-4 group as a pore-forming enhancer for anion transport [J]. | ORGANIC CHEMISTRY FRONTIERS , 2025 . |
| MLA | Fan, Jisen et al. "Dibenzo-12-crown-4 group as a pore-forming enhancer for anion transport" . | ORGANIC CHEMISTRY FRONTIERS (2025) . |
| APA | Fan, Jisen , Xu, Yingxue , Shen, Jie , Chang, Wenju , Zeng, Huaqiang . Dibenzo-12-crown-4 group as a pore-forming enhancer for anion transport . | ORGANIC CHEMISTRY FRONTIERS , 2025 . |
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Abstract ：
Membrane-active molecular machines represent a recently emerging, yet important line of expansion in the field of artificial transmembrane transporters. Their hitherto demonstrated limited types (molecular swing, ion fishers, shuttlers, rotors, etc.) certainly call for new inspiring developments. Here, we report a very first motorized ion-transporting carrier-type transporter, i.e., a modularly tunable, light-powered propeller-like transporter derived from Feringa's molecular motor for consistently boosting transmembrane ion transport under continuous UV light irradiation. Based on the EC50 values, the molecular propeller-mediated ion transport activities under UV light irradiation for 300 s are 2.31, 1.74, 2.29, 2.80, and 2.92 times those values obtained without irradiation for Li+, Na+, K+, Rb+, and Cs+ ions, respectively, with EC50 value as low as 0.71 mol % for K+ ion under light irradiation.
Keyword ：
ion transport ion transport molecularmachine molecularmachine molecular motor molecular motor molecular propeller molecular propeller supramolecular chemistry supramolecular chemistry
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| GB/T 7714 | Deng, Shaowen , Li, Zhongyan , Yuan, Lin et al. Light-Powered Propeller-like Transporter for Boosted Transmembrane Ion Transport [J]. | NANO LETTERS , 2024 , 24 (35) : 10750-10758 . |
| MLA | Deng, Shaowen et al. "Light-Powered Propeller-like Transporter for Boosted Transmembrane Ion Transport" . | NANO LETTERS 24 . 35 (2024) : 10750-10758 . |
| APA | Deng, Shaowen , Li, Zhongyan , Yuan, Lin , Shen, Jie , Zeng, Huaqiang . Light-Powered Propeller-like Transporter for Boosted Transmembrane Ion Transport . | NANO LETTERS , 2024 , 24 (35) , 10750-10758 . |
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We report here a series of alkyl group-modified trimesic amide molecules (TAs) with excellent anion transport activities. Among them, TA6, with the highest ion transport activity and excellent selectivity, efficiently transports anions across the membrane in the order of ClO4- > I- > NO3- > Br- > Cl-, with an EC50 value as low as 17.6 nM (0.022 mol% relative to lipid molecules) for ClO4-, which outperforms other anions by 5- to 22-folds and manifests as the best perchlorate transporter ever reported.
Keyword ：
anion transporter anion transporter perchlorate anion perchlorate anion transmembrane transmembrane trimesic amide trimesic amide
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| GB/T 7714 | Deng, Shaowen , Li, Zhongyan , Yuan, Lin et al. An Exceptionally Active and Highly Selective Perchlorate Transporter Containing a Trimesic Amide Scaffold [J]. | MOLECULES , 2024 , 29 (5) . |
| MLA | Deng, Shaowen et al. "An Exceptionally Active and Highly Selective Perchlorate Transporter Containing a Trimesic Amide Scaffold" . | MOLECULES 29 . 5 (2024) . |
| APA | Deng, Shaowen , Li, Zhongyan , Yuan, Lin , Zeng, Huaqiang . An Exceptionally Active and Highly Selective Perchlorate Transporter Containing a Trimesic Amide Scaffold . | MOLECULES , 2024 , 29 (5) . |
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This review is the first to focus on transmembrane transporters derived from aromatic foldamers, with most studies reported over the past decade. These foldamers have made significant strides in mimicking the essential functions of natural ion channel proteins. With their aromatic backbones rigidified by intramolecular hydrogen bonds or differential repulsive forces, this innovative family of molecules stands out for its structural diversity and functional adaptability. They achieve efficient and selective ion and molecule transport across lipid bilayers via carefully designed helical structures and tunable large cavities. Recent developments in this field highlight the transformative potential of foldamers in therapeutic applications and biomaterial engineering. Key advances include innovative molecular engineering strategies that enable highly selective ion transport by fine-tuning structural and functional attributes. Specific modifications to macrocyclic or helical foldamer structures have allowed precise control over ion selectivity and transport efficiency, with notable selectivity for K+, Li+, H+ and water molecules. Although challenges remain, future directions may focus on more innovative molecular designs, optimizing synthetic methods, improving membrane transport properties, integrating responsive designs that adapt to environmental stimuli, and fostering interdisciplinary collaborations. By emphasizing the pivotal role of aromatic foldamers in modern chemistry, this review aims to inspire further development, offering new molecular toolboxes and strategies to address technological and biological challenges in chemistry, biology, medicine, and materials science.
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| GB/T 7714 | Zhang, Danyang , Chang, Wenju , Shen, Jie et al. Aromatic foldamer-derived transmembrane transporters [J]. | CHEMICAL COMMUNICATIONS , 2024 , 60 (92) : 13468-13491 . |
| MLA | Zhang, Danyang et al. "Aromatic foldamer-derived transmembrane transporters" . | CHEMICAL COMMUNICATIONS 60 . 92 (2024) : 13468-13491 . |
| APA | Zhang, Danyang , Chang, Wenju , Shen, Jie , Zeng, Huaqiang . Aromatic foldamer-derived transmembrane transporters . | CHEMICAL COMMUNICATIONS , 2024 , 60 (92) , 13468-13491 . |
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Abstract ：
In sharp contrast to numerous artificial potassium channels developed over the past decade, the study of artificial lithium-transporting channels has remained limited. We demonstrate here the use of an interesting class of polymers with intrinsic microporosity (PIM) for constructing artificial lithium channels. These PIM-derived lithium channels show exceptionally efficient (gamma(+)(Li)>40 pS) and highly selective transport of Li+ ions, with selectivity factors of>10 against both Na+ and K+. By simply adjusting the initial reaction temperature, we can tune the transport property in a way that PIMs synthesized at initial reaction temperatures of 60 degrees C and 80 degrees C exhibit improved transport efficiency and selectivity, respectively, in the dioleoyl phosphatidylcholine membrane.
Keyword ：
Lithium Ion Channels Lithium Ion Channels Lithium Transport Lithium Transport Microporous Polymers Microporous Polymers Supramolecular Chemistry Supramolecular Chemistry Transmembrane Transport Transmembrane Transport
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| GB/T 7714 | Gou, Fei , Wang, Qiuting , Yang, Zihong et al. Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (7) . |
| MLA | Gou, Fei et al. "Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 64 . 7 (2024) . |
| APA | Gou, Fei , Wang, Qiuting , Yang, Zihong , Chang, Wenju , Shen, Jie , Zeng, Huaqiang . Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 64 (7) . |
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Abstract ：
For compounds each containing a phenylalanine moiety with its two ends amidated to have a 15-crown-5 unit and an alkyl chain, a simple tuning of the alkyl chain length delivered a K+-selective channel with a record-high K+/Na+ selectivity of 20.1.
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| GB/T 7714 | Jin, Lei , Sun, Chang , Li, Zhongyan et al. A K+-selective channel with a record-high K+/Na+ selectivity of 20.1 [J]. | CHEMICAL COMMUNICATIONS , 2023 , 59 (24) : 3610-3613 . |
| MLA | Jin, Lei et al. "A K+-selective channel with a record-high K+/Na+ selectivity of 20.1" . | CHEMICAL COMMUNICATIONS 59 . 24 (2023) : 3610-3613 . |
| APA | Jin, Lei , Sun, Chang , Li, Zhongyan , Shen, Jie , Zeng, Huaqiang . A K+-selective channel with a record-high K+/Na+ selectivity of 20.1 . | CHEMICAL COMMUNICATIONS , 2023 , 59 (24) , 3610-3613 . |
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Replicating extraordinarily high membrane transport selectivity of protein channels in artificial channel is a challenging task. In this work, we demonstrate that a strategic application of steric code-based social self-sorting offers a novel means to enhance ion transport selectivities of artificial ion channels, alongside with boosted ion transport activities. More specifically, two types of mutually compatible sterically bulky groups (benzo-crown ether and tert -butyl group) were appended onto a monopeptide-based scaffold, which can order the bulky groups onto the same side of a one-dimensionally aligned H-bonded structure. Strong steric repulsions among the same type of bulky groups (either benzo-crown ethers or tert-butyl groups), which are forced into proximity by H-bonds, favor the formation of hetero-oligomeric ensem-bles that carry an alternative arrangement of sterically compatible benzo-crown ethers and tert -butyl groups, rather than homo-oligomeric ensembles containing a single type of either benzo-crown ethers or tert -butyl groups. Coupled with side chain tuning, this social self-sorting strategy delivers highly ac-tive hetero-oligomeric K +-selective ion channel (5F12 center dot BF12)n, displaying the highest K + /Na + selectivity of 20.1 among artificial potassium channels and an excellent EC50 value of 0.50 mu mol/L (0.62 mol% relative to lipids) in terms of single channel concentration (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Artificial membrane transporters Artificial membrane transporters Artificial potassium channels Artificial potassium channels Crown ethers Crown ethers Social self-sorting Social self-sorting Supramolecular chemistry Supramolecular chemistry Transport selectivity Transport selectivity
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| GB/T 7714 | Ma, Haowen , Ye, Ruijuan , Jin, Lei et al. Highly active artificial potassium channels having record-high K plus /Na plus selectivity of 20.1 [J]. | CHINESE CHEMICAL LETTERS , 2023 , 34 (12) . |
| MLA | Ma, Haowen et al. "Highly active artificial potassium channels having record-high K plus /Na plus selectivity of 20.1" . | CHINESE CHEMICAL LETTERS 34 . 12 (2023) . |
| APA | Ma, Haowen , Ye, Ruijuan , Jin, Lei , Zhou, Shaoyuan , Ren, Changliang , Ren, Haisheng et al. Highly active artificial potassium channels having record-high K plus /Na plus selectivity of 20.1 . | CHINESE CHEMICAL LETTERS , 2023 , 34 (12) . |
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Abstract ：
Potassium channels represent the most prevalent class of ion channels, exerting regulatory control over numerous vital biological processes, including muscle contraction, neurotransmitter release, cell proliferation, and apoptosis. The seamless integration of astonishing functions into a sophisticated structure, as seen in these protein channels, inspires the chemical community to develop artificial versions, gearing toward simplifying their structure while replicating their key functions. In particular, over the past ten years or so, a number of elegant artificial potassium transporters have emerged, demonstrating high selectivity, high transport efficiency or unprecedented transport mechanisms. In this review, we will provide a detailed exposition of these artificial potassium transporters that are derived from a single molecular backbone or self-assembled from multiple components, with their respective structural designs, channel functions, transport mechanisms and biomedical applications thoroughly reviewed. In this review, we provide the very first comprehensive exposition of artificial potassium transporters developed mostly over the past ten years.
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| GB/T 7714 | Yuan, Xiyu , Shen, Jie , Zeng, Huaqiang . Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications [J]. | CHEMICAL COMMUNICATIONS , 2023 , 60 (5) : 482-500 . |
| MLA | Yuan, Xiyu et al. "Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications" . | CHEMICAL COMMUNICATIONS 60 . 5 (2023) : 482-500 . |
| APA | Yuan, Xiyu , Shen, Jie , Zeng, Huaqiang . Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications . | CHEMICAL COMMUNICATIONS , 2023 , 60 (5) , 482-500 . |
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Abstract ：
Replicating extraordinarily high membrane transport selectivity of protein channels in artificial channel is a challenging task. In this work, we demonstrate that a strategic application of steric code-based social self-sorting offers a novel means to enhance ion transport selectivities of artificial ion channels, alongside with boosted ion transport activities. More specifically, two types of mutually compatible sterically bulky groups (benzo-crown ether and tert‑butyl group) were appended onto a monopeptide-based scaffold, which can order the bulky groups onto the same side of a one-dimensionally aligned H-bonded structure. Strong steric repulsions among the same type of bulky groups (either benzo-crown ethers or tert‑butyl groups), which are forced into proximity by H-bonds, favor the formation of hetero-oligomeric ensembles that carry an alternative arrangement of sterically compatible benzo-crown ethers and tert‑butyl groups, rather than homo-oligomeric ensembles containing a single type of either benzo-crown ethers or tert‑butyl groups. Coupled with side chain tuning, this social self-sorting strategy delivers highly active hetero-oligomeric K+-selective ion channel (5F12‧BF12)n, displaying the highest K+/Na+ selectivity of 20.1 among artificial potassium channels and an excellent EC50 value of 0.50 µmol/L (0.62 mol% relative to lipids) in terms of single channel concentration © 2023
Keyword ：
Artificial membrane transporters Artificial membrane transporters Artificial potassium channels Artificial potassium channels Crown ethers Crown ethers Social self-sorting Social self-sorting Supramolecular chemistry Supramolecular chemistry Transport selectivity Transport selectivity
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| GB/T 7714 | Ma, H. , Ye, R. , Jin, L. et al. Highly active artificial potassium channels having record-high K+/Na+ selectivity of 20.1 [J]. | Chinese Chemical Letters , 2023 , 34 (12) . |
| MLA | Ma, H. et al. "Highly active artificial potassium channels having record-high K+/Na+ selectivity of 20.1" . | Chinese Chemical Letters 34 . 12 (2023) . |
| APA | Ma, H. , Ye, R. , Jin, L. , Zhou, S. , Ren, C. , Ren, H. et al. Highly active artificial potassium channels having record-high K+/Na+ selectivity of 20.1 . | Chinese Chemical Letters , 2023 , 34 (12) . |
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