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学者姓名：吕海霞
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Abstract ：
An abnormal level of alkaline phosphatase (ALP) in serum is related to many diseases, such as breast cancer, prostate cancer, hepatitis, and diabetes. The level of glucose in the blood is related to diabetes or hypoglycemia. Given the close correlation between ALP and glucose in various diseases, it is essential to establish an accurate, sensitive, and selective assay for monitoring the levels of ALP and glucose in serum. As luminescent materials, upconversion nanoparticles (UCNPs) stand out in the design of biosensors because of their high photostability, large anti-Stokes shifts and low background interference. Additionally, metal organic frameworks (MOFs) are a class of functional porous materials, and their adjustable pore size structure and high specific surface area expose many catalytic sites, making MOFs excellent catalysts and ideal materials for constructing artificial enzymes. Herein, a fluorescent and colorimetric dual-mode probe based on a multifunctional composite (UCNP@MOF) with upconversion luminescence and peroxidase-like activity was proposed for the detection of ALP and glucose. Under the optimal conditions, the detection limits of ALP and glucose by the fluorescence method were 0.046 U/ L and 0.079 mu M, respectively. Furthermore, the method was used to determine ALP and glucose in serum samples, and the detection results were similar to those of commercial kits; moreover, the recoveries were in the range of 92.7-105.4 %, indicating great potential for accurate and sensitive detection of ALP and glucose in biological samples.
Keyword ：
ALP ALP Glucose Glucose Metal-organic framework Metal-organic framework Upconversion nanoparticle Upconversion nanoparticle
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| GB/T 7714 | Zhao, Tianlu , Dong, Yi , Chen, Kaixuan et al. A dual-mode biosensor based on metal organic framework-coated upconversion composites with near-infrared luminescence and peroxidase-like activity for the detection of alkaline phosphatase and glucose [J]. | TALANTA , 2025 , 284 . |
| MLA | Zhao, Tianlu et al. "A dual-mode biosensor based on metal organic framework-coated upconversion composites with near-infrared luminescence and peroxidase-like activity for the detection of alkaline phosphatase and glucose" . | TALANTA 284 (2025) . |
| APA | Zhao, Tianlu , Dong, Yi , Chen, Kaixuan , Lyu, Haixia . A dual-mode biosensor based on metal organic framework-coated upconversion composites with near-infrared luminescence and peroxidase-like activity for the detection of alkaline phosphatase and glucose . | TALANTA , 2025 , 284 . |
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To improve the photocatalytic performance of carbon nitride (g-C3N4), a flower-shaped COCN/ZIS composite was synthesized by growing ZnIn2S4 (ZIS) onto structurally defective g-C3N4 (COCN) nanosheets. The experimental results indicate that the prepared photocatalyst has excellent photocatalytic performance for the degradation of methylene blue (MB), with an apparent rate constant of 0.0661 min−1, which is approximately 6.89, 6.06 and 7.39 times greater than that of g-C3N4 (0.0096 min−1), COCN (0.01091 min−1) and ZIS (0.00895 min−1), separately. The improvement in the photocatalytic performance of COCN/ZIS can be attributed to the defect structure of COCN and the well-matched relationship between COCN and ZIS, both of which result in valid photoinduced charge separation and migration. This has also been confirmed by the synergy coefficient (3.33). Furthermore, the total organic carbon content (TOC) removal rates of MB and wastewater by the 60-COCN/ZIS composite were 85.96 % and 75.32 %, respectively, suggesting that the resultant catalyst has potential application in the photodegradation treatment of MB. Finally, the capture experiments and electron paramagnetic resonance analysis show that ·OH, ·O2– and h+ species are generated during the process, among which ·OH plays a great part in the photodegradation of MB by the COCN/ZIS compound. © 2024 Elsevier B.V.
Keyword ：
g-C3N4 g-C3N4 Photocatalytic degradation Photocatalytic degradation Structural defects Structural defects ZnIn2S4 ZnIn2S4
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| GB/T 7714 | Li, Y. , Chen, Y. , Lyu, H. et al. Construction of a flower-shaped g-C3N4/ZnIn2S4 composite with heterogeneous structural defects for highly efficient photocatalytic degradation of pollutants [J]. | Journal of Photochemistry and Photobiology A: Chemistry , 2024 , 457 . |
| MLA | Li, Y. et al. "Construction of a flower-shaped g-C3N4/ZnIn2S4 composite with heterogeneous structural defects for highly efficient photocatalytic degradation of pollutants" . | Journal of Photochemistry and Photobiology A: Chemistry 457 (2024) . |
| APA | Li, Y. , Chen, Y. , Lyu, H. , Xie, Z. . Construction of a flower-shaped g-C3N4/ZnIn2S4 composite with heterogeneous structural defects for highly efficient photocatalytic degradation of pollutants . | Journal of Photochemistry and Photobiology A: Chemistry , 2024 , 457 . |
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Heparin is a highly negatively charged sulfated linear polymer glycosaminoglycan that has been widely used as an anticoagulant in medicine. Protamine is a cationic protein rich in arginine that is used to treat the blood-brain barrier during excess heparin surgery. Trypsin is the most important digestive enzyme-encoding generated by the pancreas and can specifically cleave the carboxyl ends of arginine and lysine residues. Heparin, protamine, and trypsin interact and constrain each other, and their fluctuations reflect the body's dysfunction. Therefore, it is necessary to develop a fast, sensitive, and highly selective assay for regularly monitoring the levels of heparin, protamine, and trypsin in serum. Herein, a fluorescent and colorimetric dual-mode upconversion nanoparticle (UCNP) biosensor was used for the determination of heparin, protamine, and trypsin based on the oxidase-mimicking activity of Ce4+ and electrostatic control. The biosensor exhibited sensitive detection of heparin, protamine, and trypsin with low limits of detection (LODs) of 16 ng/mL, 87 ng/mL and 31 ng/mL, respectively. Furthermore, the designed biosensor could eliminate autofluorescence, which not only effectively increased the accuracy of the sensor but also provided a new sensing pathway for the detection of differently charged biotargets. © 2024 Elsevier B.V.
Keyword ：
Arginine Arginine Biosensors Biosensors Electrostatics Electrostatics Enzymes Enzymes Nanoparticles Nanoparticles Polysaccharides Polysaccharides
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| GB/T 7714 | Hu, Gaoya , Yue, Daoping , Chen, Weishuan et al. Dual-mode upconversion sensors for detecting differently charged biotargets based on the oxidase-mimicking activity of Ce4+ and electrostatic control [J]. | Talanta , 2024 , 277 . |
| MLA | Hu, Gaoya et al. "Dual-mode upconversion sensors for detecting differently charged biotargets based on the oxidase-mimicking activity of Ce4+ and electrostatic control" . | Talanta 277 (2024) . |
| APA | Hu, Gaoya , Yue, Daoping , Chen, Weishuan , Lin, Qingqing , Lyu, Haixia . Dual-mode upconversion sensors for detecting differently charged biotargets based on the oxidase-mimicking activity of Ce4+ and electrostatic control . | Talanta , 2024 , 277 . |
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稀土上转换纳米粒子(UCNPs)因其具有毒性小、化学稳定性好和背景荧光低等优点被用于构建荧光纳米传感器.通过溶剂热法制备核壳UCNPs,采用柠檬酸钠对其进行表面配体交换得到水溶性核壳UCNPs(Cit-CS-UCNPs),以Cit-CS-UCNPs作为荧光传感器的能量供体,二氧化锰(MnO2)纳米片作为荧光传感器的能量受体,采用荧光共振能量转移(FRET)机理,构建了一种用于食品添加剂二氧化氢(H2O2)和叔丁基对苯二酚(TBHQ)检测的荧光纳米传感器(Cit-CS-UCNPs-MnO2).通过扫描电镜(SEM)、荧光光谱和紫外可见吸收光谱(UV-Vis)等分析测试手段对制备的纳米材料的形貌结构和性能进行表征.考察了猝灭剂浓度、孵育温度及孵育时间等实验条件对荧光传感体系检测性能的影响.荧光光谱和UV-Vis实验结果表明,Cit-CS-UCNPs最大发射峰位于654 nm,Cit-CS-UCNPs与MnO2结合后,核壳UCNPs发生荧光猝灭,当存在H2O2时,Cit-CS-UCNPs的荧光恢复,说明在此波段H2O2与MnO2纳米片发生氧化还原反应,MnO2纳米片被还原成Mn2+,逐渐从Cit-CS-UCNPs的表面解离下来;存在TBHQ时,Cit-CS-UCNPs-MnO2与TBHQ体系峰位与TBHQ偏移到253 nm,为TBHQ与MnO2纳米片发生氧化还原反应,使得Cit-CS-UCNPs-MnO2体系中FRET效应减弱,荧光强度回升.SEM结果表明,MnO2纳米片均匀包覆在Cit-CS-UCNPs的周围,在水中仍可保持良好的分散性,表明MnO2纳米片修饰到Cit-CS-UCNPs表面.对猝灭剂高锰酸钾(KMnO4)的浓度进行了优化.结果表明,当KMnO4浓度为10 mol·L-1时,猝灭效率可达90％.对检测条件进行优化,结果表明H2O2的检测孵育时间为25 min时,MnO2和H2O2之间氧化还原反应基本完全,Cit-CS-UCNPs-MnO2荧光恢复值最大;TBHQ的检测孵育时间为30 min.在最佳实验条件下,Cit-CS-UCNPs-MnO2 的荧光强度变化比率与 H2O2 浓度(0～1 000 μmol·L-1)及 TBHQ 浓度(0～0.6 mmol·L-1)分别具有良好的线性关系.保持最佳实验条件,选取食品中存在的代表性金属离子(如K+、Na+、Ca2+和Mg2+)和常见的食品添加剂苯甲酸(BA)、D-葡萄糖(Glu)、山梨酸钾(PS)、蔗糖(Suc)、纳他霉素(Nat)和肌醇(Ino)作为研究对象进行选择性测试,发现与H2O2相比,Cit-CS-UCNPs-MnO2对其他添加物质没有强烈的反应,传感器整体荧光信号波动不大,因此Cit-CS-UCNPs-MnO2对H2O2和TBHQ可进行特异性检测.
Keyword ：
上转换纳米粒子 上转换纳米粒子 核壳结构 核壳结构 荧光纳米传感器 荧光纳米传感器
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| GB/T 7714 | 张璇 , 王雅森 , 温娜 et al. 基于稀土上转换纳米粒子传感器的构建及其在食品添加剂检测中的应用 [J]. | 光谱学与光谱分析 , 2024 , 44 (9) : 2459-2466 . |
| MLA | 张璇 et al. "基于稀土上转换纳米粒子传感器的构建及其在食品添加剂检测中的应用" . | 光谱学与光谱分析 44 . 9 (2024) : 2459-2466 . |
| APA | 张璇 , 王雅森 , 温娜 , 吕海霞 , 李宝铭 . 基于稀土上转换纳米粒子传感器的构建及其在食品添加剂检测中的应用 . | 光谱学与光谱分析 , 2024 , 44 (9) , 2459-2466 . |
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Rare earth up-conversion nanoparticles (UCNPs) have been used to construct fluorescent nanosensors because of their low toxicity, good chemical stability, and low background fluorescence. Core-shell UCNPs were prepared using the solvothermal method, and water-soluble core-shell UCNPs (Cit-CS-UCNPs) were obtained by surface ligand exchange with sodium citrate. The Cit-CS-UCNPs were used as the energy donor of the fluorescence sensor, and manganese dioxide (MnO2) nanosheets were used as the energy receptor of the fluorescence sensor. Based on the fluorescence resonance energy transfer (FRET) mechanism, a fluorescence nanosensor (Cit-CS-UCNPs-MnO2) was constructed for the detection of hydrogen dioxide (H2O2) and tert-butylhydroquinone (TBHQ ) as food additives. The prepared nanomaterials' morphology, structure, and properties were characterized by scanning electron microscopy (SEM), fluorescence spectrum, and ultraviolet spectrum (UV-vis). The effects of quenching agent concentration, incubation temperature, and incubation time on the detection performance of the fluorescence sensing system were investigated. According to the fluorescence spectra and UV-Vis experimental results, the maximum emission peak of Cit-CS-UCNPs is 654 nm. After the combination of Cit-CS-UCNPs and MnO2, core-shell UCNPs undergo fluorescence quenching. When H2O2 is present, the fluorescence of Cit-CS-UCNPs recovers. The results indicate that H2O2 and MnO2 nanosheets undergo redox reaction at this band, and MnO2 nanosheets are reduced to Mn2+, which gradually dissociates from the surface of Cit-CS-UCNPs. In the presence of TBHQ, the peak of the Cit-CS-UCNPs-MnO2 and TBHQ system was shifted to 253 nm, indicating that the redox reaction occurred between TBHQ and MnO2 nanosheets, and the FRET effect was reduced in the Cit-CS-UCNPs-MnO2 system, and the fluorescence intensity increased. It can be seen from the SEM results that MnO2 nanosheets are uniformly coated around Cit-CS-UCNPs, and maintain good dispersion in water, indicating that MnO2 nanosheets are modified on the surface of Cit-CS-UCNPs. The concentration of the quencher potassium permanganate (KMnO4) was optimized, and the results showed that when the concentration of KMnO4 is 10 mol.L-1, the quenching efficiency can reach 90%. The detection conditions were optimized, and the results showed that when the incubation time of H2O2 was 25 min, the redox reaction between MnO2 and H2O2 was complete. The fluorescence recovery value of Cit-CS-UCNPs-MnO2 was the maximum. The incubation time of TBHQ was 30 min. Under the optimal experimental conditions, the fluorescence intensity of Cit-CS-UCNPs-MnO2 has a good linear relationship with the concentration of H2O2 (0 similar to 1 000 mu mol.L-1) and TBHQ (0 similar to 0.6 mmol.L-1). The optimal experimental conditions were maintained, and representative metal ions (such as K+, Na+, Ca2+ and Mg2+) and common food additives (BA, Glu, PS, Suc, Nat and Ino) in food were selected as research objects. The results showed that compared with H2O2, Cit-CS-UCNPs-MnO2 did not react strongly to other added substances, and the overall fluorescence signal of the sensor did not fluctuate much. Therefore, it can be seen that Cit-CS-UCNPs-MnO2 can detect the specificity of H2O2 and TBHQ.
Keyword ：
Core shell structures Core shell structures Fluorescent nanosensor Fluorescent nanosensor Up conversion nanoparticles Up conversion nanoparticles
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| GB/T 7714 | Zhang, Xuan , Wang, Ya-sen , Na, Wen et al. Construction of a Rare Earth Up-Conversion Nanoparticle Sensor and Its Application in the Detection of Food Additives [J]. | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2024 , 44 (9) : 2459-2466 . |
| MLA | Zhang, Xuan et al. "Construction of a Rare Earth Up-Conversion Nanoparticle Sensor and Its Application in the Detection of Food Additives" . | SPECTROSCOPY AND SPECTRAL ANALYSIS 44 . 9 (2024) : 2459-2466 . |
| APA | Zhang, Xuan , Wang, Ya-sen , Na, Wen , Lu, Hai-xia , Li, Bao-ming . Construction of a Rare Earth Up-Conversion Nanoparticle Sensor and Its Application in the Detection of Food Additives . | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2024 , 44 (9) , 2459-2466 . |
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To improve the photocatalytic performance of carbon nitride (g-C3N4), a flower-shaped COCN/ZIS composite was synthesized by growing ZnIn2S4 (ZIS) onto structurally defective g-C3N4 (COCN) nanosheets. The experimental results indicate that the prepared photocatalyst has excellent photocatalytic performance for the degradation of methylene blue (MB), with an apparent rate constant of 0.0661 min(-1), which is approximately 6.89, 6.06 and 7.39 times greater than that of g-C3N4 (0.0096 min(-1)), COCN (0.01091 min(-1)) and ZIS (0.00895 min(-1)), separately. The improvement in the photocatalytic performance of COCN/ZIS can be attributed to the defect structure of COCN and the well-matched relationship between COCN and ZIS, both of which result in valid photoinduced charge separation and migration. This has also been confirmed by the synergy coefficient (3.33). Furthermore, the total organic carbon content (TOC) removal rates of MB and wastewater by the 60-COCN/ZIS composite were 85.96 % and 75.32 %, respectively, suggesting that the resultant catalyst has potential application in the photodegradation treatment of MB. Finally, the capture experiments and electron paramagnetic resonance analysis show that center dot OH, center dot O-2(-) and h(+) species are generated during the process, among which center dot OH plays a great part in the photodegradation of MB by the COCN/ZIS compound.
Keyword ：
g-C3N4 g-C3N4 Photocatalytic degradation Photocatalytic degradation Structural defects Structural defects ZnIn2S4 ZnIn2S4
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| GB/T 7714 | Li, Yangqing , Chen, Yan , Lyu, Haixia et al. Construction of a flower-shaped g-C3N4/ZnIn2S4 composite with heterogeneous structural defects for highly efficient photocatalytic degradation of pollutants [J]. | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY , 2024 , 457 . |
| MLA | Li, Yangqing et al. "Construction of a flower-shaped g-C3N4/ZnIn2S4 composite with heterogeneous structural defects for highly efficient photocatalytic degradation of pollutants" . | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY 457 (2024) . |
| APA | Li, Yangqing , Chen, Yan , Lyu, Haixia , Xie, Zenghong . Construction of a flower-shaped g-C3N4/ZnIn2S4 composite with heterogeneous structural defects for highly efficient photocatalytic degradation of pollutants . | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY , 2024 , 457 . |
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Heparin is a highly negatively charged sulfated linear polymer glycosaminoglycan that has been widely used as an anticoagulant in medicine. Protamine is a cationic protein rich in arginine that is used to treat the blood-brain barrier during excess heparin surgery. Trypsin is the most important digestive enzyme-encoding generated by the pancreas and can specifically cleave the carboxyl ends of arginine and lysine residues. Heparin, protamine, and trypsin interact and constrain each other, and their fluctuations reflect the body's dysfunction. Therefore, it is necessary to develop a fast, sensitive, and highly selective assay for regularly monitoring the levels of heparin, protamine, and trypsin in serum. Herein, a fluorescent and colorimetric dual-mode upconversion nanoparticle (UCNP) biosensor was used for the determination of heparin, protamine, and trypsin based on the oxidasemimicking activity of Ce4+ and electrostatic control. The biosensor exhibited sensitive detection of heparin, protamine, and trypsin with low limits of detection (LODs) of 16 ng/mL, 87 ng/mL and 31 ng/mL, respectively. Furthermore, the designed biosensor could eliminate autofluorescence, which not only effectively increased the accuracy of the sensor but also provided a new sensing pathway for the detection of differently charged biotargets.
Keyword ：
Electrostatic control Electrostatic control Heparin Heparin Protamine Protamine Trypsin Trypsin Upconversion nanoparticles Upconversion nanoparticles
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| GB/T 7714 | Hu, Gaoya , Yue, Daoping , Chen, Weishuan et al. Dual-mode upconversion sensors for detecting differently charged biotargets based on the oxidase-mimicking activity of Ce4+and electrostatic control [J]. | TALANTA , 2024 , 277 . |
| MLA | Hu, Gaoya et al. "Dual-mode upconversion sensors for detecting differently charged biotargets based on the oxidase-mimicking activity of Ce4+and electrostatic control" . | TALANTA 277 (2024) . |
| APA | Hu, Gaoya , Yue, Daoping , Chen, Weishuan , Lin, Qingqing , Lyu, Haixia . Dual-mode upconversion sensors for detecting differently charged biotargets based on the oxidase-mimicking activity of Ce4+and electrostatic control . | TALANTA , 2024 , 277 . |
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The photocatalytic degradation of dyes by graphitic carbon nitrides (g-C3N4) under sunlight has received increased attention. However, the fast recombination of charge carriers still restricts its photocatalytic application. To overcome this drawback, a g-C3N4/Mn3O4/ZIF-8 (CMZ) composite was prepared to activate peroxymonosulfate (PMS)-based advanced oxidation processes for degradation of rhodamine B (RhB) in water. Under visible light, the catalysts exhibited high activity and stability in activating PMS to generate radicals ((OH)-O-center dot, O-center dot(2)- and SO4 center dot-) and the maximum RhB degradation of approximately 94.34 % was achieved. The RhB degradation followed first-order kinetics and the rate constant of g-C3N4/Mn3O4/ZIF-8/PMS system was 2.85, 3.09, 9.82 and 17 times of g-C3N4, Mn3O4, ZIF-8 and PMS, respectively. Moreover, the synergistic effect of CMZ and PMS on the removal efficiencies of total organic carbon (TOC) for RhB and wastewater were 92.84 % and 96.13 %, respectively. After five cycles of use, the degradation rate of the prepared catalyst for RhB only decreased by 1.7 %. This work provided new insights that the synergistic effect of advanced oxidation technologies and photocatalysis holds broad prospects for the photodegradation of RhB.
Keyword ：
g-C3N4 g-C3N4 Mn3O4 Mn3O4 Peroxymonosulfate Peroxymonosulfate Rhodamine B (RhB) Rhodamine B (RhB) ZIF-8 ZIF-8
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| GB/T 7714 | Li, Yangqing , Zhang, Xiaofeng , Huang, Chengke et al. A g-C3N4/Mn3O4/ZIF-8 composite for efficient degradation of dyes by activating peroxymonosulfate [J]. | OPTICAL MATERIALS , 2024 , 149 . |
| MLA | Li, Yangqing et al. "A g-C3N4/Mn3O4/ZIF-8 composite for efficient degradation of dyes by activating peroxymonosulfate" . | OPTICAL MATERIALS 149 (2024) . |
| APA | Li, Yangqing , Zhang, Xiaofeng , Huang, Chengke , Lyu, Haixia . A g-C3N4/Mn3O4/ZIF-8 composite for efficient degradation of dyes by activating peroxymonosulfate . | OPTICAL MATERIALS , 2024 , 149 . |
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As the reliable biomarkers to evaluate the diabetes and neurological disease, sensitive and accurate detection of glucose and glutathione (GSH) in biological samples is necessary for early precaution and diagnosis of relateddiseases. The single red upconversion nanoparticles (UCNPs) especially with core-shell structure can penetrate deeper biological tissues and cause less energy loss and thus have higher sensitivity and accuracy. Additionally, an enzyme-controlled cascade signal amplification (ECSAm) strategy will further enhance sensitivity. Herein, using single red UCNPs with core-shell structure as the luminescent material, a fluorescent sensor based on ECSAm was developed for the highly sensitive and accurate detection of glucose and GSH. Under the optimal conditions, the limits of detection for glucose and GSH by fluorescent method were 0.03 mu M and 0.075 mu M, separately. This assay was used to analyze the content of glucose and GSH in serum samples, and the obtained data was close to that of commercial blood glucose and GSH detection kit. The developed sensor platform based on single red UCNPs with core-shell structure and ECSAm can be a promising method for the accurate and sensitive detection of glucose and GSH in biological samples.
Keyword ：
Fluorescent sensor Fluorescent sensor Glucose Glucose Glutathione Glutathione Serum Serum Single red upconversion nanoparticles Single red upconversion nanoparticles
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| GB/T 7714 | Zhao, Tianlu , Wu, Dongzhi , Zhang, Xuecheng et al. A fluorescent sensor based on single band bright red luminescent core-shell UCNPs for the high-sensitivity detection of glucose and glutathione [J]. | ANALYTICA CHIMICA ACTA , 2024 , 1295 . |
| MLA | Zhao, Tianlu et al. "A fluorescent sensor based on single band bright red luminescent core-shell UCNPs for the high-sensitivity detection of glucose and glutathione" . | ANALYTICA CHIMICA ACTA 1295 (2024) . |
| APA | Zhao, Tianlu , Wu, Dongzhi , Zhang, Xuecheng , Lyu, Haixia . A fluorescent sensor based on single band bright red luminescent core-shell UCNPs for the high-sensitivity detection of glucose and glutathione . | ANALYTICA CHIMICA ACTA , 2024 , 1295 . |
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The overexpression of microRNA-222 (miRNA-222) is closely related to many human diseases, so the development of biosensors to detect this biomarker will contribute to the diagnosis of related diseases. Here, a simple, sensitive and specific fluorescence assay for the detection of miRNA-222 was developed using red-emitting upconversion nanoparticle (UCNP) as the donor and a DNA hairpin with black hole quencher-2 (BHQ-2) as the acceptor. Li+ and Tm3+-doped UCNP with a strong emission peak at 654 nm was obtained by changing the doped ion ratio and constructing core-shell structures. Under optimal conditions, the linear range for detecting miRNA-222 is 0.5-2.5 nM and the limit of detection is as low as 0.077 nM without any complicated amplification strategy. Finally, the proposed assay was applied for the detection of miRNA-222 in serum samples. The results obtained were similar to those of the standard method, and the spiked recoveries were in the range of 97.62%- 102.14 %, suggesting that the proposed method has practical value in a complex biological sample matrix.
Keyword ：
DNA-Functionalized DNA-Functionalized miRNA miRNA Red-emitting Red-emitting UCNP UCNP
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| GB/T 7714 | Li, Yingchao , Tu, Canzhao , Chen, Qianshun et al. Enhanced red emission of upconversion nanoparticles via Li+ and Tm3+codoping and active core-shell construction for sensitive detection of miRNAs [J]. | ANALYTICA CHIMICA ACTA , 2024 , 1335 . |
| MLA | Li, Yingchao et al. "Enhanced red emission of upconversion nanoparticles via Li+ and Tm3+codoping and active core-shell construction for sensitive detection of miRNAs" . | ANALYTICA CHIMICA ACTA 1335 (2024) . |
| APA | Li, Yingchao , Tu, Canzhao , Chen, Qianshun , Lin, Yingying , Li, Baoming , Lyu, Haixia . Enhanced red emission of upconversion nanoparticles via Li+ and Tm3+codoping and active core-shell construction for sensitive detection of miRNAs . | ANALYTICA CHIMICA ACTA , 2024 , 1335 . |
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