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学者姓名：林悦
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采用鲁米诺/H2O2 作为微通道电化学发光(ECL)报告体系,构建了一种微通道ECL传感器用于四环素(TC)的检测.鲁米诺/H2O2 ECL体系较低的激发电位可以降低体系钳位电压的影响,从而提高微通道ECL传感器的检测性能.修饰了四环素适配体(TC-aptamer)的微通道可特异性识别并捕获TC,TC带有的正电荷导致微通道内界面负电荷密度降低,使微通道的离子电流增加,导致体系ECL信号增强.对电解质浓度、TC-aptamer修饰液浓度、TC与TC-aptamer的反应时间等条件进行了优化.在最优条件下,体系ECL信号变化值与TC浓度在1.00～200 ng/mL范围内呈良好的线性关系,检出限为0.69 ng/mL.此传感器具有良好的选择性,并成功用于牛奶样本中TC的检测.
Keyword ：
四环素 四环素 微通道 微通道 电化学发光 电化学发光 适配体 适配体 鲁米诺 鲁米诺
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| GB/T 7714 | 黄少坤 , 谢秀琳 , 蔡华宾 et al. 以鲁米诺/过氧化氢作为报告体系的微通道电化学发光传感器用于四环素的检测 [J]. | 分析化学 , 2025 , 53 (3) : 356-363 . |
| MLA | 黄少坤 et al. "以鲁米诺/过氧化氢作为报告体系的微通道电化学发光传感器用于四环素的检测" . | 分析化学 53 . 3 (2025) : 356-363 . |
| APA | 黄少坤 , 谢秀琳 , 蔡华宾 , 黄艳玲 , 林悦 , 林振宇 . 以鲁米诺/过氧化氢作为报告体系的微通道电化学发光传感器用于四环素的检测 . | 分析化学 , 2025 , 53 (3) , 356-363 . |
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A highly efficient and sensitive non-enzymatic glucose sensor fabricated using NiO/NiPc composite nanomaterials was introduced by this study. The sensor employed a unique design by modifying the ITO electrode with the NiO/NiPc heterojunction. This enhancement was achieved by improving charge separation and transfer through the type-II heterojunction formed between NiO and NiPc. The integration of NiO/NiPc composite materials also improved the electrocatalytic activity. This enhancement was attributed to the increased concentration of oxygen vacancies, thereby boosting the overall performance of the sensor. The results of the sensor application demonstrated that under the optimized conditions (pH 4.0, -0.3 V bias), the sensor exhibited remarkable sensitivity and selectivity towards glucose, with a linear relationship between the photocurrent change and glucose concentration. The detection limit was as low as 0.016 nM, and the sensitivity was 4.146 mu A & sdot;mM- 1 & sdot;cm- 2. The sensor demonstrated excellent repeatability, stability, and high recovery rate in real sweat sample testing, highlighting its great potential for practical glucose detection applications.
Keyword ：
Glucose Glucose NiO NiO NiPc NiPc Photoelectrochemical sensor Photoelectrochemical sensor
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| GB/T 7714 | Xue, Xiaoyan , Wu, Wenru , Yang, Yating et al. Oxygen vacancy-enriched NiO/NiPc heterojunction for highly efficient and sensitive non-enzymatic glucose sensing [J]. | MICROCHEMICAL JOURNAL , 2025 , 208 . |
| MLA | Xue, Xiaoyan et al. "Oxygen vacancy-enriched NiO/NiPc heterojunction for highly efficient and sensitive non-enzymatic glucose sensing" . | MICROCHEMICAL JOURNAL 208 (2025) . |
| APA | Xue, Xiaoyan , Wu, Wenru , Yang, Yating , Lin, Yue , Luo, Fang , Lin, Cuiying et al. Oxygen vacancy-enriched NiO/NiPc heterojunction for highly efficient and sensitive non-enzymatic glucose sensing . | MICROCHEMICAL JOURNAL , 2025 , 208 . |
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Detecting of hyaluronidase (HAase) activity is vital in oncology as it drives tumor invasion and metastasis by degrading hyaluronic acid (HA) in the extracellular matrix. In this study, combining a target-responsive hydrogel with magnetic nanozymes, a novel colorimetric sensor was designed for HAase quantification. The composite of Fe₃O₄ and MoS₂ (Fe3O4@MoS2) has magnetism activity and strong peroxidase-like activity, simultaneously has embedded in a hydrogel matrix format from HA, the presence of HAase can specific hydrolysis HA, and caused the rupture of the hydrogel and results in the releasing of the Fe3O4@MoS2. The released Fe3O4@MoS2 can be collected through magnetic separation easily and then applied to catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H2O2, producing a distinct color change, which can be detected by naked eyes easily. The absorbance of the system had a good linear response with HAase concentration within the range of 2.5–90 U/mL, with a limit of detection (LOD) of 1.4 U/mL (S/N = 3). The proposed sensor was successfully applied to detect HAase in serum samples from healthy individuals and pancreatic cancer patients, yielding satisfactory results. © 2025 Elsevier B.V.
Keyword ：
Colorimetric sensor Colorimetric sensor Fe3O4@MoS2 Fe3O4@MoS2 Hyaluronidase Hyaluronidase Target responsive system Target responsive system
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| GB/T 7714 | Yang, J. , Deng, Y. , Chen, Z. et al. Colorimetric sensor for hyaluronidase activity detection based on target-responsive hydrogel embedded with magnetic nanozyme [J]. | Microchemical Journal , 2025 , 216 . |
| MLA | Yang, J. et al. "Colorimetric sensor for hyaluronidase activity detection based on target-responsive hydrogel embedded with magnetic nanozyme" . | Microchemical Journal 216 (2025) . |
| APA | Yang, J. , Deng, Y. , Chen, Z. , Lin, Y. , Chen, D. , Lin, C. et al. Colorimetric sensor for hyaluronidase activity detection based on target-responsive hydrogel embedded with magnetic nanozyme . | Microchemical Journal , 2025 , 216 . |
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A microchannel-based electrochemiluminescence (ECL) sensor was developed for detection of tetracycline (TC) utilizing luminol/H2O2 as ECL reporting system. The low excitation potential of luminol/H2O2 effectively mitigated the impact of clamping voltage, thereby enhancing the detection performance of the microchannel-based ECL sensor. The microchannel modified with TC aptamer selectively recognized and captured target TC. The positively charged TC reduced the surface charge density within the microchannel, thereby increasing the ionic current in the microchannel, leading to change of ECL signal of system. The experimental conditions such as electrolyte concentration, TC-aptamer concentration, and reaction time between TC and TC-aptamer were optimized. Under optimal conditions, the difference of ECL signal in the absence and presence of TC (triangle ECL) exhibited a good linear relationship with TC concentration in the range from 1.00 ng/mL to 200 ng/mL, with a detection limit as low as 0.69 ng/mL. The sensor had good selectivity and was successfully used in detection of TC in milk samples.
Keyword ：
Aptamer Aptamer Electrochemiluminescence Electrochemiluminescence Luminol Luminol Microchannel Microchannel Tetracycline Tetracycline
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| GB/T 7714 | Huang, Shao-Kun , Xie, Xiu-Lin , Cai, Hua-Bin et al. Microchannel-based Electrochemiluminescence Sensor for Tetracycline Detection Using Luminol/Hydrogen Peroxide as Reporter System [J]. | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2025 , 53 (3) : 356-363 . |
| MLA | Huang, Shao-Kun et al. "Microchannel-based Electrochemiluminescence Sensor for Tetracycline Detection Using Luminol/Hydrogen Peroxide as Reporter System" . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 53 . 3 (2025) : 356-363 . |
| APA | Huang, Shao-Kun , Xie, Xiu-Lin , Cai, Hua-Bin , Huang, Yan-Ling , Lin, Yue , Lin, Zhen-Yu . Microchannel-based Electrochemiluminescence Sensor for Tetracycline Detection Using Luminol/Hydrogen Peroxide as Reporter System . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2025 , 53 (3) , 356-363 . |
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The persistence of T-2 toxin in food and feed matrices renders it a pervasive contaminant, impacting both human and animal health. Traditional detection methods suffer from cumbersome instrumentation and intricate procedures, rendering on-site detection of T-2 toxin unfeasible. Therefore, we have constructed a real-time detection method for T-2 toxin detection by employing a target-responsive DNA hydrogel in conjunction with potassium iodide starch test paper. This method integrates both colorimetric and distance-based signal outputs, offering a streamlined and effective approach for the on-site detection of T-2 toxin. The specific binding of the target to the aptamer in the DNA hydrogel results in the collapse of the hydrogels structure, which changes the viscosity of the system and released horseradish peroxidase in the hydrogel wrapped, and then produces blue-purple marks of different lengths on the starch iodide papers to achieve the specific detection of T-2 toxin. Under optimized conditions, the assay exhibits a detection range spanning from 10 ng/mL to 10 mg/mL for the toxin, with a detection limit of 12.83 ng/mL. The proposed method has been successfully applied for the detection of real corn samples with satisfied result. Such colorimetric-distance dual signal detection method offers notable advantages, including straightforward operation, clear signal interpretation, and practical utility. Its implementation enables rapid, on-the-spot detection of T-2 toxin, particularly beneficial in resource-limited regions and less developed countries.
Keyword ：
Point-of-care testing Point-of-care testing Starch iodide paper Starch iodide paper T-2 toxin T-2 toxin Target-responsive DNA hydrogel Target-responsive DNA hydrogel
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| GB/T 7714 | Deng, Ye , Lin, Jiarong , Wang, Jingxuan et al. Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper [J]. | MICROCHEMICAL JOURNAL , 2025 , 210 . |
| MLA | Deng, Ye et al. "Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper" . | MICROCHEMICAL JOURNAL 210 (2025) . |
| APA | Deng, Ye , Lin, Jiarong , Wang, Jingxuan , Lin, Yue , Luo, Fang , Weng, Zuquan et al. Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper . | MICROCHEMICAL JOURNAL , 2025 , 210 . |
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Filling the microchannel with negatively charged hydrogel can exhibit microsacle ion current rectification (ICR) behavior, which is attributed to the space negative charge and structural asymmetry of hydrogel. In this study, this character had been applied to develop a trypsin sensor for the first time. A hydrogel synthesized with bovine serum albumin (BSA) and glyoxal (BSAG hydrogel) was filled at the tip of microchannel firstly. Subsequently, the BSAG hydrogel-filled microchannel was immersed in a trypsin solution to hydrolyze the BSA within the BSAG hydrogel. This process changes the space charge density and pore size of the BSAG hydrogel-filled microchannel, leading to a change in microscale ICR, which can be used for quantifying trypsin. Then the key parameters affecting the sensing performance such as the concentration of BSA, strength of the electrolyte, pH and reaction time were optimized. The detection range was from 10.0 ng/mL to 100 mu g/mL with a detection limit as low as 2.55 ng/mL (S/N = 3). Due to the distinctive three-dimensional pore structure of the hydrogel and the specificity of trypsin for BSA hydrolysis, the sensor exhibits high sensitivity and specificity, as well as remarkable reproducibility and stability. This sensor has been effectively used to measure trypsin levels in human serum samples.
Keyword ：
Hydrogel Hydrogel Microchannel Microchannel Microscale ionic current rectification Microscale ionic current rectification Space negtive charge Space negtive charge Trypsin Trypsin
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| GB/T 7714 | Cai, Huabin , Yuan, Runhao , Huang, Shaokun et al. Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel [J]. | TALANTA , 2025 , 285 . |
| MLA | Cai, Huabin et al. "Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel" . | TALANTA 285 (2025) . |
| APA | Cai, Huabin , Yuan, Runhao , Huang, Shaokun , Huang, Yanling , Lin, Cuiying , Lin, Yue et al. Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel . | TALANTA , 2025 , 285 . |
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Soluble suppression of tumorigenicity 2 (sST2) is a critical biomarker for heart failure (HF) diagnosis and prognosis, yet conventional antibody-based detection methods suffer from time-consuming protocols and high costs and involve complex detection procedures. To address these challenges, we first screened high-affinity aptamers under clinically relevant conditions and then coupled with the CRISPR/Cas12a system to develop a fluorescence aptasensor for rapid and sensitive sST2 detection. A serum matrix was introduced during aptamer selection to enhance specificity and anti-interference performance in real biological environments. Three sST2-specific aptamers (Apt-1, Apt-2, and Apt-3) were identified with dissociation constants (K D ) of 8.42, 46.08, and 25.02 nM, respectively. Among these, Apt-1 demonstrated superior performance, which was utilized to construct a fluorescence biosensor combining aptamer recognition with CRISPR/Cas12a trans-cleavage signal amplification. The sensor achieved a broad linear detection range (5-120 ng/mL) and an ultralow limit of detection (LOD, 0.816 ng/mL) when applied in detecting sST2 in both the buffer and human serum. Notably, the platform exhibited exceptional resistance to interference from HF-related proteins and maintained high accuracy in clinical serum samples, showing a strong correlation (R 2 = 0.9794) with enzyme-linked immunosorbent assay (ELISA) results. By integration of serum-matrix screening and CRISPR-based signal enhancement, this work establishes a robust, cost-effective, and rapid diagnostic tool for sST2 detection.
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| GB/T 7714 | Qiu, Shuqian , Chen, Li , Zhuang, Dongqing et al. Fluorescence Aptasensor for sST2 Detection Using In Vitro Selected Aptamers [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (20) : 10910-10918 . |
| MLA | Qiu, Shuqian et al. "Fluorescence Aptasensor for sST2 Detection Using In Vitro Selected Aptamers" . | ANALYTICAL CHEMISTRY 97 . 20 (2025) : 10910-10918 . |
| APA | Qiu, Shuqian , Chen, Li , Zhuang, Dongqing , Cao, Yue , Wei, Renli , Cao, Xiaoai et al. Fluorescence Aptasensor for sST2 Detection Using In Vitro Selected Aptamers . | ANALYTICAL CHEMISTRY , 2025 , 97 (20) , 10910-10918 . |
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Seafood consumption is the major source of total Hg (tHg) and methyl mercury (MeHg) for humans. Lack of broad-representative bio-accessibility of mercury species makes accurate assessment on health risk of seafood's mercury impossible. Herein, the concentrations and in vitro bio-accessibilities of mercury species in 93 seafood samples with 71 different species were extensively investigated. Results indicated that all shellfish and fish samples, and most seaweed samples contained both Hg2+ and MeHg, while some seaweed samples contained only Hg2+. The concentrations of mercury species varied depending on the differences in species/individuals of seafood and sampling regions. MeHg in seafood can be partly de-methylated into Hg2+ during gastrointestinal digestion, which reduced the toxicity of mercury in seafood. The mean demethylation rate of MeHg varied as follows: seaweeds (similar to 62.1 %) > shellfishes/shrimps (similar to 19.7 %) > fishes (similar to 9.2 %). The mean bio-accessibility of Hg2+ and tHg varied as follows: seaweeds (similar to 97.7 % and similar to 90.1 %) > shellfishes/shrimps (similar to 65.1 % and similar to 67.9 %) approximate to fishes (similar to 65.1 % and similar to 66.7 %), while that of MeHg varied as follows: fishes (similar to 57.7 %) > shellfishes/shrimps (50.8 %) > seaweeds (similar to 11.6 %). The simulated calculation of target hazard quotient (THQ) revealed that the health risk of seafood's mercury may be accurately assessed using tHg, not mercury species, even without considering bio-accessibility. This offers a simple but protective approach for assessing the health risk of seafood's mercury. Results of this study provide the potential broad-representative bio-accessibilities of mercury species existing in various kinds of seafood and novel insights for scientifically assessing the health risk of seafood's mercury and revising the mercury limitation in seafood.
Keyword ：
Bioavailability Bioavailability Marine organism Marine organism Mercury Mercury Risk assessment Risk assessment Seafood Seafood
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| GB/T 7714 | Sun, Chaochen , Yin, Miaomiao , Peng, Ying et al. The characteristic and bio-accessibility evaluation of mercury species in various kinds of seafood collected from Fujian of China for mercury risk assessment [J]. | JOURNAL OF HAZARDOUS MATERIALS , 2025 , 482 . |
| MLA | Sun, Chaochen et al. "The characteristic and bio-accessibility evaluation of mercury species in various kinds of seafood collected from Fujian of China for mercury risk assessment" . | JOURNAL OF HAZARDOUS MATERIALS 482 (2025) . |
| APA | Sun, Chaochen , Yin, Miaomiao , Peng, Ying , Lin, Chen , Wu, Yongning , Fu, Fengfu et al. The characteristic and bio-accessibility evaluation of mercury species in various kinds of seafood collected from Fujian of China for mercury risk assessment . | JOURNAL OF HAZARDOUS MATERIALS , 2025 , 482 . |
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The contamination of micro-plastics (MPs)/nano-plastics (NPs) in environment poses a global concern, necessitating a scientific evaluation of their potential risks to ecosystems and organisms. We herein investigated the adsorption kinetics of different mercury species including inorganic mercury (Hg2+), methylmercury (MeHg) and ethylmercury (EtHg) on three different MPs, such as polyethylene MPs (PE MPs), polypropylene MPs (PP MPs) and polystyrene MPs (PS MPs) in micro-polluted water in detail, and further evaluated the individual and combined cytotoxicity of polystyrene NPs (PS NPs)/polypropylene NPs (PP NPs) and different mercury species. The results indicated that EtHg undergoes demethylation partly to form Hg2+ during the adsorption process on PP MPs, and the adsorption kinetics of Hg2+, MeHg and EtHg on three MPs fitted with pseudo-first-order (PFO) model in initial stage and simultaneously fitted with pseudo-second-order (PSO) model during whole adsorption process. This suggested that adsorption of mercury species on three MPs we driven mainly by physical process in initial stage and by chemical process during whole absorption process. In natural micro-polluted water, the equilibrium adsorption capacities (Qe) of Hg2+ on three MPs (156.3–270.3 ng/g) are much higher than that of MeHg (5.562–78.13 ng/g) and EtHg (7.831–70.42 ng/g). Cytotoxicity experiments revealed that PP NPs and PS NPs themselves have little cytotoxicity, but the presence of them can enhance the cytotoxicity of mercury species, showing NPs size-depended and mercury species-depended synergistic toxic effect. The findings of this study provided valuable insights for scientifically evaluating the potential risk of MPs/NPs to ecosystems and organisms. © 2025 Elsevier B.V.
Keyword ：
Marine pollution Marine pollution Microplastic Microplastic Risk assessment Risk assessment River pollution River pollution Water analysis Water analysis
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| GB/T 7714 | Wu, Siqi , Yang, Chen , Xu, Haochen et al. Adsorption kinetics of different mercury species on three kinds of micro-/nano-plastics in micro-polluted aquatic environments and their combined toxicity [J]. | Science of the Total Environment , 2025 , 981 . |
| MLA | Wu, Siqi et al. "Adsorption kinetics of different mercury species on three kinds of micro-/nano-plastics in micro-polluted aquatic environments and their combined toxicity" . | Science of the Total Environment 981 (2025) . |
| APA | Wu, Siqi , Yang, Chen , Xu, Haochen , Zhu, Yiwei , Fu, FengFu , Lin, Yue . Adsorption kinetics of different mercury species on three kinds of micro-/nano-plastics in micro-polluted aquatic environments and their combined toxicity . | Science of the Total Environment , 2025 , 981 . |
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Histamine is a kind of biogenic amine released in spoiled food, which can serve as a key indicator for assessing the freshness of seafood. It is important to develop some efficient methods for histamine detection. In this work, a dual-emission europium-metal-organic framework (Eu-MOF) was designed and applied to design a ratiometric fluorescence sensing strategy for histamine detection. The MOF was synthesized in one step using two ligands: 5-boronoisophthalic acid (5-BOP) and 2-hydroxyterephthalic acid (BDC-OH). Eu3+ was sensitized by 5-BOP through the antenna effect and exhibited red emission at 618 nm, while the BDC-OH exhibited bright blue emission at 434 nm. The MOF displayed dual-emission responses to histamine, characterized by an increase in 434 nm and a concomitant decrease at 618 nm, so the ratio of I 618/I 434 decreased with a pronounced fluorescence color shift from purple to blue. I 618/I 434 exhibited a linear range with histamine from 0 to 200 mg/L with a detection limit of 0.17 mg/L (LOD = 3 sigma/KSV). The synthesized Eu-BOP/BDC-OH was integrated with carrageenan to fabricate a hydrogel composite film for portable detection of histamine, and the changing of color can be utilized for semiquantitative freshness detection. The proposed method provided a reliable and efficient portable strategy for histamine detection in seafood.
Keyword ：
histamine histamine hydrogel composite film hydrogel composite film MOF MOF ratiometric fluorescence sensor ratiometric fluorescence sensor seafood freshness seafood freshness
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| GB/T 7714 | Cheng, Mengxin , Cao, Ying , Chen, Lifen et al. Portable Fluorescence Histamine Sensor for Assessing Freshness Utilizing Hydrogel Embedded with Dual-Ligand Europium Metal-Organic Framework [J]. | ACS SENSORS , 2025 , 10 (6) : 4580-4588 . |
| MLA | Cheng, Mengxin et al. "Portable Fluorescence Histamine Sensor for Assessing Freshness Utilizing Hydrogel Embedded with Dual-Ligand Europium Metal-Organic Framework" . | ACS SENSORS 10 . 6 (2025) : 4580-4588 . |
| APA | Cheng, Mengxin , Cao, Ying , Chen, Lifen , Lin, Yue , Luo, Fang , Guo, Longhua et al. Portable Fluorescence Histamine Sensor for Assessing Freshness Utilizing Hydrogel Embedded with Dual-Ligand Europium Metal-Organic Framework . | ACS SENSORS , 2025 , 10 (6) , 4580-4588 . |
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