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学者姓名：李梅金
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Abstract ：
The judicious utilization of antibiotics has established a robust bulwark for human health. However, their improper usage has engendered deleterious ramifications on the environment, underscoring the imperative for developing efficacious and cost-effective detection and degradation platforms. This study presents a sulfur-modified iron-cobalt bimetallic single-atom nitrogen-doped carbon catalyst (S-FeCo-NC) with a noncopper active center. In contrast to conventional laccase, which utilizes copper as its active center, the S-FeCo-NC catalyst exhibits multiple enzyme activities, including laccase-like, peroxidase-like, and catalase-like functions, with iron and cobalt serving as the active centers. As a proof of concept, the combined laccase-like and catalase-like functions of S-FeCo-NC were used as independent signal outputs, while a multienzyme cascade dual-mode assay system was designed for the rapid detection of tetracycline (TC) in combination with peroxidase-like enzymes. In this system, oxygen directly participated in the catalytic process of laccase-like as an electron acceptor, while catalase-like peroxidase efficiently catalyzed the production of O2 from H2O2. The elevated concentration of O2 offered a unique advantage for the increased catalytic activity of the laccase-like enzyme, which outputs visually resolved colorimetric signals using stable 4-aminopyridine with oxidized TC. Furthermore, the peroxidase-like activity of S-FeCo-NC catalyzed the generation of OH radicals with strong oxidative properties, and these radicals carried out effective oxidative decomposition of TC. The signal output of the response of the catalytic process was performed using differential pulse cyclic voltammetry, which further improved the sensitivity and accuracy of the detection. The experimental findings demonstrate that the detection system exhibits a favorable response signal to TC within the range of 0.005-500 mu M, with its detection range reaching 0.5-500 and 0.005-1.00 mu M, respectively, and the detection limit is as low as 0.22 mu M and 1.68 nM, respectively. This cascade dual-mode detection system, based on multienzyme activity, has been shown to significantly enhance the catalytic activity of laccase, while also demonstrating stability in a lower detection range. This suggests that it may offer a novel approach for the sensitive detection and degradation of environmental pollutants.
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| GB/T 7714 | Wang, Yunsen , Tian, Shuo , Chen, Shuyun et al. S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (13) : 7526-7535 . |
| MLA | Wang, Yunsen et al. "S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay" . | ANALYTICAL CHEMISTRY 97 . 13 (2025) : 7526-7535 . |
| APA | Wang, Yunsen , Tian, Shuo , Chen, Shuyun , Li, Meijin , Tang, Dianping . S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay . | ANALYTICAL CHEMISTRY , 2025 , 97 (13) , 7526-7535 . |
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S: Mercury ions (Hg2+) are highly toxic and prone to bioaccumulation, showing a strong attraction to proteins and enzymes that contain sulfur. Even minute quantities of Hg2+ can lead to severe health issues. Given that mitochondria are a primary target organelle of Hg2+, it is essential to create a probe that can accurately detect Hg2+ within intracellular mitochondria. In this study, we developed two innovative Ir(III) complex probes that emit near-infrared light. The crystal structure of Ir2 was determined using X-ray techniques, which reveals that Ir2 contains a pyridine group capable of recognizing Hg2+ and targeting mitochondria, allowing for the precise identification of Hg2+ both in vitro and within the mitochondria of living cells. Additionally, these two novel near-infrared phosphorescent Ir(III) complexes demonstrate significant capabilities in producing ROS including singlet oxygen, center dot O-2(-) and center dot OH, which renders them effective photosensitizers under visible light exposure for photodynamic therapy (PDT). This research offers a promising approach for detecting Hg2+ in vitro and in the mitochondrial microenvironment of living cells, which have some implications for the future development of pertinent transition metal complexes for mitochondria-targeted photodynamic therapy in cancer cells.
Keyword ：
Hg2+ sensing Hg2+ sensing Ir(III) complexes Ir(III) complexes Luminescence imaging Luminescence imaging Near-infrared phosphorescence Near-infrared phosphorescence Photodynamic therapy Photodynamic therapy
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| GB/T 7714 | Liu, Jie , Chen, Meihua , Li, Mei-Jin . Mitochondria-targeted and near-infrared phosphorescent Ir(III) complexes for specific detection of Hg2+ and photodynamic therapy [J]. | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY , 2025 , 337 . |
| MLA | Liu, Jie et al. "Mitochondria-targeted and near-infrared phosphorescent Ir(III) complexes for specific detection of Hg2+ and photodynamic therapy" . | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 337 (2025) . |
| APA | Liu, Jie , Chen, Meihua , Li, Mei-Jin . Mitochondria-targeted and near-infrared phosphorescent Ir(III) complexes for specific detection of Hg2+ and photodynamic therapy . | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY , 2025 , 337 . |
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A highly charged water-soluble iridium(III) (Ir(III)) complex [(ppy)2Ir(bpy-N)]3+ was designed, synthesized and characterized, and the crystal structure of it was determined by X-ray crystallography. The photophysical properties of complex in absence or presence of sodium heparin were studied by UV-vis absorption and photoluminescent spectroscopies. After addition of sodium heparin, the luminescent intensity of complex at ca. 656 nm was increased about 4.3-fold, without any observable color change in the solution. The new Ir(III) complex was also assembled with gold nanoparticles (AuNPs) for the dual-mode detection of sodium heparin, combined with colorimetric and luminescent methods. In this system, the luminescence of complex was quenched by AuNPs firstly with the red color of gold nano colloids transition into blue due to the aggregation. The color of the assembled system changed from blue to purple to red accompanying with the luminescent intensity of system restoring after increasing the concentrations of added sodium heparin. The sodium heparin was sensitively detected with LOD of 0.09 mu g/mL. This work demonstrates a novel bifunctional sensing platform for sodium heparin, leveraging the unique photophysical properties of the Ir(III) complex and the plasmonic behavior of AuNPs, offering significant potential for sensitive and visual detection applications.
Keyword ：
Colorimetric sensing Colorimetric sensing Gold nanoparticles Gold nanoparticles Iridium(III) complex Iridium(III) complex photoluminescence photoluminescence Sodium heparin Sodium heparin
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| GB/T 7714 | Lin, Jinshan , Wang, Shengjie , Jiao, Pengchong et al. Colorimetric and luminescent determination of heparin based on assembly between a highly charged iridium(III) complex and gold nanoparticles [J]. | JOURNAL OF MOLECULAR STRUCTURE , 2025 , 1337 . |
| MLA | Lin, Jinshan et al. "Colorimetric and luminescent determination of heparin based on assembly between a highly charged iridium(III) complex and gold nanoparticles" . | JOURNAL OF MOLECULAR STRUCTURE 1337 (2025) . |
| APA | Lin, Jinshan , Wang, Shengjie , Jiao, Pengchong , Li, Mei-Jin . Colorimetric and luminescent determination of heparin based on assembly between a highly charged iridium(III) complex and gold nanoparticles . | JOURNAL OF MOLECULAR STRUCTURE , 2025 , 1337 . |
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Nanozyme-based electrochemical biosensors have emerged as an alternative to enzyme-based biosensors for next-generation bioanalysis. However, potential antibody modifications limit the catalytic sites of the nanozyme, thereby reducing sensor sensitivity. Here, a sensitive method for determining carcinoembryonic antigen (CEA) was developed. It involved coupling a cascade enzyme-enzyme-like catalytic reaction using Fe-Co Prussian blue analog nanozymes with high peroxidase-like activity (79.42 U mg-1). Briefly, the transduction of biological signals to chemical signals was achieved through the strategy centered on catalytic electroactive probes. Thereafter, with the assistance of the microelectrochemical workstation, the output of signals was realized. The platform exhibited an ultra-wide range of 0.020-100 ng mL-1 and a detection limit of 0.013 ng mL-1 CEA, which was mainly attributed to the excellent peroxidase activity, good conductivity, and synergistic amplification of current signals of synthesized nanozymes. In addition, the modification-free features greatly reduced the complexity of the bioassay and significantly improves its portability and cost-effectiveness. Overall, this study advances the development of nanozymes and their electrochemical biosensing applications and is expected to extend to the development of miniaturized devices in direct detection environments.
Keyword ：
Bifunctional nanozyme Bifunctional nanozyme Carcinoembryonic antigen Carcinoembryonic antigen Catalytic amplification Catalytic amplification Electrochemical immunoassay Electrochemical immunoassay
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| GB/T 7714 | Chen, Shuyun , Tian, Shuo , Wang, Yunsen et al. Harnessing bifunctional nanozyme with potent catalytic and signal amplification for innovating electrochemical immunoassay [J]. | BIOSENSORS & BIOELECTRONICS , 2025 , 278 . |
| MLA | Chen, Shuyun et al. "Harnessing bifunctional nanozyme with potent catalytic and signal amplification for innovating electrochemical immunoassay" . | BIOSENSORS & BIOELECTRONICS 278 (2025) . |
| APA | Chen, Shuyun , Tian, Shuo , Wang, Yunsen , Li, Meijin , Tang, Dianping . Harnessing bifunctional nanozyme with potent catalytic and signal amplification for innovating electrochemical immunoassay . | BIOSENSORS & BIOELECTRONICS , 2025 , 278 . |
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Sluggish charge transfer and rapid electron-hole recombination severely limit the analytical performance of photoelectrochemical (PEC) immunoassays. This work presented a PEC immunosensing strategy that employed a target-induced enzyme-catalyzed reaction to in-situ generate oxygen vacancy (Ov) for amplifying the photocurrent detection of carcinoembryonic antigen (CEA). Concretely, ascorbic acid-2-phosphate (AAP) was catalyzed to produce ascorbic acid (AA) by alkaline phosphatase (ALP) in the presence of CEA. The generated AA could serve as a reducing agent to introduce oxygen vacancy (Ov) into the etching tungsten trioxide (E-WO3) photoanode, resulting in an Ov-enriched E-WO3 (E-WO3-Ov) photoanode. The formation of Ov allowed efficient introduction of defect levels into the energy band structure of E-WO3-Ov photoanode, resulting in high charge transfer and electron-hole separation efficiency for photocurrent amplification. Later, it was applied to fabricate a PEC immunosensor, thus enabling a wide linear range from 0.02 to 80 ng/mL and a low detection limit of 12.9 pg/mL. Overall, this work presented a promising sensing strategy for PEC immunosensors, expanding the scope of potential applications in bioassays and clinical diagnostics.
Keyword ：
Charge transfer Charge transfer Defect level Defect level Electron-hole separation Electron-hole separation Oxygen vacancy Oxygen vacancy Photoelectrochemical immunoassay Photoelectrochemical immunoassay
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| GB/T 7714 | Qin, Jiao , Yu, Zhichao , Wu, Di et al. Target-induced oxygen vacancy on the etching WO3 photoanode for in-situ amplified photoelectrochemical immunoassay [J]. | BIOSENSORS & BIOELECTRONICS , 2025 , 279 . |
| MLA | Qin, Jiao et al. "Target-induced oxygen vacancy on the etching WO3 photoanode for in-situ amplified photoelectrochemical immunoassay" . | BIOSENSORS & BIOELECTRONICS 279 (2025) . |
| APA | Qin, Jiao , Yu, Zhichao , Wu, Di , Li, Meijin , Tang, Dianping . Target-induced oxygen vacancy on the etching WO3 photoanode for in-situ amplified photoelectrochemical immunoassay . | BIOSENSORS & BIOELECTRONICS , 2025 , 279 . |
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| GB/T 7714 | Zheng, Kai , Pan, Jiangfei , Yu, Zipei et al. A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF ( vol 258, 125310, 2024) [J]. | TALANTA , 2024 , 269 . |
| MLA | Zheng, Kai et al. "A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF ( vol 258, 125310, 2024)" . | TALANTA 269 (2024) . |
| APA | Zheng, Kai , Pan, Jiangfei , Yu, Zipei , Yi, Changqing , Li, Mei-Jin . A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF ( vol 258, 125310, 2024) . | TALANTA , 2024 , 269 . |
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Photodynamic therapy is an emerging tumor therapy that kills tumor cells by activating reactive oxygen species (ROS) produced by photosensitizers. Mitochondria, as an important organelle, are the main generator of cellular ROS. Therefore, the development of photosensitizers capable of targeting mitochondria could significantly enhance the efficacy of photodynamic therapy. In this study, two novel ruthenium(ii) complexes, Ru-1 and Ru-2, were designed and synthesized, both of which were functionalized with alpha,beta-unsaturated ketones for sensing of glutathione (GSH). The crystal structures of the two complexes were determined and they exhibited good recognition of GSH by off-on luminescence signals. The complex Ru-2 containing aromatic naphthalene can enter the cells and react with GSH to generate a strong luminescence signal that can be used to monitor intracellular GSH levels through imaging. Ru-2 also has an excellent mitochondrial localization ability with a Pearson's coefficient of 0.95, which demonstrates that it can efficiently target the mitochondria of tumor cells to enhance the effectiveness of photodynamic therapy as a photosensitizer.
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| GB/T 7714 | Zhang, Wanqing , Chen, Weibin , Fu, Fengfu et al. Mitochondria-targeted ruthenium(ii) complexes for photodynamic therapy and GSH detection in living cells [J]. | DALTON TRANSACTIONS , 2024 , 53 (13) : 5957-5965 . |
| MLA | Zhang, Wanqing et al. "Mitochondria-targeted ruthenium(ii) complexes for photodynamic therapy and GSH detection in living cells" . | DALTON TRANSACTIONS 53 . 13 (2024) : 5957-5965 . |
| APA | Zhang, Wanqing , Chen, Weibin , Fu, Fengfu , Li, Mei-Jin . Mitochondria-targeted ruthenium(ii) complexes for photodynamic therapy and GSH detection in living cells . | DALTON TRANSACTIONS , 2024 , 53 (13) , 5957-5965 . |
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A smartphone-assisted electrochemiluminescence (ECL) strategy based on Ru(bpy)(2)(L)(4+) as chromophores confined with metal - organic frameworks (Ru(bpy)(2)(L)(4+)@MOF-5) for the signal-amplified detection of miRNA-21 was developed. We synthesized a derivative of tris(2,2'-bipyridyl)ruthenium(II) complex (Ru(bpy)(2)(L)(4+)) with high charges, which can be loaded into the MOF-5 by strong electrostatic interaction to prevent from leakage. In addition, nucleic acid cycle amplification was used to quench the signal of Ru(bpy)(2)(L)(4+)@MOF-5 by ferrocene. This method was applied to detect the concentration of miRNA-21 ranging from 1.0 x 10(-14)-1.0 x 10(-9) M with a low LOD of 7.2 fM. This work demonstrated the construction of a signal quenching strategy ECL biosensor for miRNA using Ru(bpy)(2)(L)(4+)@MOF-5 systems and its application in smartphone-assisted ECL detection.
Keyword ：
Electrochemiluminescence Electrochemiluminescence MicroRNA MicroRNA MOF-5 MOF-5 Ru(II) complex Ru(II) complex Signal amplification Signal amplification Smartphone-assisted detection Smartphone-assisted detection
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| GB/T 7714 | Zheng, Kai , Zheng, Qianghui , Mu, Xiangjun et al. A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5 [J]. | MICROCHIMICA ACTA , 2024 , 191 (10) . |
| MLA | Zheng, Kai et al. "A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5" . | MICROCHIMICA ACTA 191 . 10 (2024) . |
| APA | Zheng, Kai , Zheng, Qianghui , Mu, Xiangjun , Li, Mei-Jin , Yi, Changqing . A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5 . | MICROCHIMICA ACTA , 2024 , 191 (10) . |
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Hydrogen sulfide (H2S) is an important sulfur-containing signaling molecule in the human body, as well as a highly toxic gas that is soluble in water. A variety of pathological processes are associated with abnormal metabolism of hydrogen sulfide, so it is very important to develop an assay that can rapidly and specifically detect H2S. In this work, two iridium(III) complexes were designed and synthesized using ester groups as reaction sites for recognition of H2S. As the H2S concentration increased, the photoluminescence of the probe was rapidly quenched within 5 s, with a detection limit as low as 0.45 mu M. Among them, the probe Ir1, whose luminescence was located in the visible region, had been successfully used for the detection of trace amounts of H2S in water samples with a recovery rate of 92.5 similar to 104.0% and a relative standard deviation (RSD, n = 5) of < 2.8%. The luminescence of probe Ir2 was located in the near-infrared region, which could avoid the interference of biological autofluorescence and be successfully used for luminescence imaging of H2S in HeLa cells. This study provided a promising method for rapid detection of trace H2S in water samples and cellular microenvironments.
Keyword ：
H2S H2S Iridium(III) complexes Iridium(III) complexes Luminescence imaging Luminescence imaging Photoluminescence Photoluminescence Sensing Sensing
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| GB/T 7714 | Mu, Xiangjun , Zhang, Wanqing , Li, Mei-Jin et al. Design and synthesis of two iridium(III) complex probes for rapid sensing of hydrogen sulfide [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 401 . |
| MLA | Mu, Xiangjun et al. "Design and synthesis of two iridium(III) complex probes for rapid sensing of hydrogen sulfide" . | SENSORS AND ACTUATORS B-CHEMICAL 401 (2023) . |
| APA | Mu, Xiangjun , Zhang, Wanqing , Li, Mei-Jin , Fu, Fengfu . Design and synthesis of two iridium(III) complex probes for rapid sensing of hydrogen sulfide . | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 401 . |
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This work designed a liposome-mediated photocurrent polarity switching immunosensor depending on the reversed photocurrent of iodine-doped BiOCl (I-BOC) nanoflowers induced by the released methylene blue (MB) for the detection of prostate-specific antigen (PSA). Initially, MB-loaded liposomes as indicators were confined within the microplates to participate in the sandwiched immunoreaction and lysed under the treatment of Triton X-100 to release numerous MB. Owing to the host-guest recognition between beta-cyclodextrin (beta-CD) and MB, the released MB was immobilized on the beta-CD-modified I-BOC/FTO electrode and triggered the photocurrent polarity reversal from cathodic photocurrent to anodic photocurrent. The sensing platform realized an accurate and sensitive assay of PSA due to the effective elimination of false-positive/negative signals in a linear range of 0.02-50 ng mL-1 with a limit of detection of 12 pg mL-1. Furthermore, this work not only conjugated liposomeassisted signal amplification strategy with the photocurrent polarity switching system but also provided a novel pathway for various protein determinations.
Keyword ：
Iodine-doped BiOCl nanoflowers Iodine-doped BiOCl nanoflowers Low-abundance protein Low-abundance protein Methylene blue-loaded liposome Methylene blue-loaded liposome Photocurrent-polarity switching Photocurrent-polarity switching Photoelectrochemical immunoassay Photoelectrochemical immunoassay
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| GB/T 7714 | Lin, Qianyun , Lu, Liling , Huang, Xue et al. Photocurrent-polarity switching between methylene blue-loaded liposome and iodine-doped BiOCl for in-situ amplified immunoassay [J]. | TALANTA , 2023 , 268 . |
| MLA | Lin, Qianyun et al. "Photocurrent-polarity switching between methylene blue-loaded liposome and iodine-doped BiOCl for in-situ amplified immunoassay" . | TALANTA 268 (2023) . |
| APA | Lin, Qianyun , Lu, Liling , Huang, Xue , Li, Meijin , Tang, Dianping . Photocurrent-polarity switching between methylene blue-loaded liposome and iodine-doped BiOCl for in-situ amplified immunoassay . | TALANTA , 2023 , 268 . |
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