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学者姓名：李梅金
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Abstract ：
The judicious utilization of antibiotics has established a robust bulwark for human health. However, their improper usage has engendered deleterious ramifications on the environment, underscoring the imperative for developing efficacious and cost-effective detection and degradation platforms. This study presents a sulfur-modified iron-cobalt bimetallic single-atom nitrogen-doped carbon catalyst (S-FeCo-NC) with a noncopper active center. In contrast to conventional laccase, which utilizes copper as its active center, the S-FeCo-NC catalyst exhibits multiple enzyme activities, including laccase-like, peroxidase-like, and catalase-like functions, with iron and cobalt serving as the active centers. As a proof of concept, the combined laccase-like and catalase-like functions of S-FeCo-NC were used as independent signal outputs, while a multienzyme cascade dual-mode assay system was designed for the rapid detection of tetracycline (TC) in combination with peroxidase-like enzymes. In this system, oxygen directly participated in the catalytic process of laccase-like as an electron acceptor, while catalase-like peroxidase efficiently catalyzed the production of O2 from H2O2. The elevated concentration of O2 offered a unique advantage for the increased catalytic activity of the laccase-like enzyme, which outputs visually resolved colorimetric signals using stable 4-aminopyridine with oxidized TC. Furthermore, the peroxidase-like activity of S-FeCo-NC catalyzed the generation of OH radicals with strong oxidative properties, and these radicals carried out effective oxidative decomposition of TC. The signal output of the response of the catalytic process was performed using differential pulse cyclic voltammetry, which further improved the sensitivity and accuracy of the detection. The experimental findings demonstrate that the detection system exhibits a favorable response signal to TC within the range of 0.005-500 mu M, with its detection range reaching 0.5-500 and 0.005-1.00 mu M, respectively, and the detection limit is as low as 0.22 mu M and 1.68 nM, respectively. This cascade dual-mode detection system, based on multienzyme activity, has been shown to significantly enhance the catalytic activity of laccase, while also demonstrating stability in a lower detection range. This suggests that it may offer a novel approach for the sensitive detection and degradation of environmental pollutants.
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| GB/T 7714 | Wang, Yunsen , Tian, Shuo , Chen, Shuyun et al. S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (13) : 7526-7535 . |
| MLA | Wang, Yunsen et al. "S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay" . | ANALYTICAL CHEMISTRY 97 . 13 (2025) : 7526-7535 . |
| APA | Wang, Yunsen , Tian, Shuo , Chen, Shuyun , Li, Meijin , Tang, Dianping . S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay . | ANALYTICAL CHEMISTRY , 2025 , 97 (13) , 7526-7535 . |
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Abstract ：
1.“correlation coefficient” in abstract (line 9) and page 6,column 1, last paragraph (line 8) should be changed to “coefficient of determination ". 2.“pDNA” in page 3, column 2, section 2.3 (line 8) should be changed to “probe DNA (pDNA)". 3."cDNA” in page 4, column 1, line 1 should be changed to “complementary DNA (cDNA)" The authors would like to apologise for any inconvenience caused. © 2023 Elsevier B.V.
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| GB/T 7714 | Zheng, K. , Pan, J. , Yu, Z. et al. Corrigendum to “A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF” [Talanta 258 (2024)125310] (Talanta (2024) 268(P1), (S0039914023010615), (10.1016/j.talanta.2023.125310)) [未知]. |
| MLA | Zheng, K. et al. "Corrigendum to “A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF” [Talanta 258 (2024)125310] (Talanta (2024) 268(P1), (S0039914023010615), (10.1016/j.talanta.2023.125310))" [未知]. |
| APA | Zheng, K. , Pan, J. , Yu, Z. , Yi, C. , Li, M.-J. . Corrigendum to “A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF” [Talanta 258 (2024)125310] (Talanta (2024) 268(P1), (S0039914023010615), (10.1016/j.talanta.2023.125310)) [未知]. |
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A smartphone-assisted electrochemiluminescence (ECL) strategy based on Ru(bpy)2(L)4+ as chromophores confined with metal − organic frameworks (Ru(bpy)2(L)4+@MOF-5) for the signal-amplified detection of miRNA-21 was developed. We synthesized a derivative of tris(2,2’-bipyridyl)ruthenium(II) complex (Ru(bpy)2(L)4+) with high charges, which can be loaded into the MOF-5 by strong electrostatic interaction to prevent from leakage. In addition, nucleic acid cycle amplification was used to quench the signal of Ru(bpy)2(L)4+@MOF-5 by ferrocene. This method was applied to detect the concentration of miRNA-21 ranging from 1.0 × 10−14-1.0 × 10−9 M with a low LOD of 7.2 fM. This work demonstrated the construction of a signal quenching strategy ECL biosensor for miRNA using Ru(bpy)2(L)4+@MOF-5 systems and its application in smartphone-assisted ECL detection. Graphical abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024.
Keyword ：
Electrochemiluminescence Electrochemiluminescence MicroRNA MicroRNA MOF-5 MOF-5 Ru(II) complex Ru(II) complex Signal amplification Signal amplification Smartphone-assisted detection Smartphone-assisted detection
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| GB/T 7714 | Zheng, K. , Zheng, Q. , Mu, X. et al. A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5 [J]. | Microchimica Acta , 2024 , 191 (10) . |
| MLA | Zheng, K. et al. "A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5" . | Microchimica Acta 191 . 10 (2024) . |
| APA | Zheng, K. , Zheng, Q. , Mu, X. , Li, M.-J. , Yi, C. . A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5 . | Microchimica Acta , 2024 , 191 (10) . |
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Photodynamic therapy is an emerging tumor therapy that kills tumor cells by activating reactive oxygen species (ROS) produced by photosensitizers. Mitochondria, as an important organelle, are the main generator of cellular ROS. Therefore, the development of photosensitizers capable of targeting mitochondria could significantly enhance the efficacy of photodynamic therapy. In this study, two novel ruthenium(ii) complexes, Ru-1 and Ru-2, were designed and synthesized, both of which were functionalized with alpha,beta-unsaturated ketones for sensing of glutathione (GSH). The crystal structures of the two complexes were determined and they exhibited good recognition of GSH by off-on luminescence signals. The complex Ru-2 containing aromatic naphthalene can enter the cells and react with GSH to generate a strong luminescence signal that can be used to monitor intracellular GSH levels through imaging. Ru-2 also has an excellent mitochondrial localization ability with a Pearson's coefficient of 0.95, which demonstrates that it can efficiently target the mitochondria of tumor cells to enhance the effectiveness of photodynamic therapy as a photosensitizer.
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| GB/T 7714 | Zhang, Wanqing , Chen, Weibin , Fu, Fengfu et al. Mitochondria-targeted ruthenium(ii) complexes for photodynamic therapy and GSH detection in living cells [J]. | DALTON TRANSACTIONS , 2024 , 53 (13) : 5957-5965 . |
| MLA | Zhang, Wanqing et al. "Mitochondria-targeted ruthenium(ii) complexes for photodynamic therapy and GSH detection in living cells" . | DALTON TRANSACTIONS 53 . 13 (2024) : 5957-5965 . |
| APA | Zhang, Wanqing , Chen, Weibin , Fu, Fengfu , Li, Mei-Jin . Mitochondria-targeted ruthenium(ii) complexes for photodynamic therapy and GSH detection in living cells . | DALTON TRANSACTIONS , 2024 , 53 (13) , 5957-5965 . |
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A smartphone-assisted electrochemiluminescence (ECL) strategy based on Ru(bpy)(2)(L)(4+) as chromophores confined with metal - organic frameworks (Ru(bpy)(2)(L)(4+)@MOF-5) for the signal-amplified detection of miRNA-21 was developed. We synthesized a derivative of tris(2,2'-bipyridyl)ruthenium(II) complex (Ru(bpy)(2)(L)(4+)) with high charges, which can be loaded into the MOF-5 by strong electrostatic interaction to prevent from leakage. In addition, nucleic acid cycle amplification was used to quench the signal of Ru(bpy)(2)(L)(4+)@MOF-5 by ferrocene. This method was applied to detect the concentration of miRNA-21 ranging from 1.0 x 10(-14)-1.0 x 10(-9) M with a low LOD of 7.2 fM. This work demonstrated the construction of a signal quenching strategy ECL biosensor for miRNA using Ru(bpy)(2)(L)(4+)@MOF-5 systems and its application in smartphone-assisted ECL detection.
Keyword ：
Electrochemiluminescence Electrochemiluminescence MicroRNA MicroRNA MOF-5 MOF-5 Ru(II) complex Ru(II) complex Signal amplification Signal amplification Smartphone-assisted detection Smartphone-assisted detection
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| GB/T 7714 | Zheng, Kai , Zheng, Qianghui , Mu, Xiangjun et al. A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5 [J]. | MICROCHIMICA ACTA , 2024 , 191 (10) . |
| MLA | Zheng, Kai et al. "A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5" . | MICROCHIMICA ACTA 191 . 10 (2024) . |
| APA | Zheng, Kai , Zheng, Qianghui , Mu, Xiangjun , Li, Mei-Jin , Yi, Changqing . A smartphone-assisted electrochemiluminescent biosensor for highly sensitive detection of miRNA-21 based on Ru(bpy)2(L)4+@MOF-5 . | MICROCHIMICA ACTA , 2024 , 191 (10) . |
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| GB/T 7714 | Zheng, Kai , Pan, Jiangfei , Yu, Zipei et al. A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF ( vol 258, 125310, 2024) [J]. | TALANTA , 2024 , 269 . |
| MLA | Zheng, Kai et al. "A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF ( vol 258, 125310, 2024)" . | TALANTA 269 (2024) . |
| APA | Zheng, Kai , Pan, Jiangfei , Yu, Zipei , Yi, Changqing , Li, Mei-Jin . A smartphone-assisted electrochemiluminescent detection of miRNA-21 in situ using Ru(bpy)32+@MOF ( vol 258, 125310, 2024) . | TALANTA , 2024 , 269 . |
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This work presents a photocurrent-polarity-switching-based photoelectrochemical (PEC) biosensing platform for ultrasensitive detection of microRNA-21 (miR-21) through target-triggered catalytic hairpin assembly (CHA) for modulation of methylene blue (MB) and ferrocene (Fc) positional configurations using double-shelled Cu-doped ZnS nanocages (NCs)-Au nanoparticles (NPs) as photoactive materials. In the presence of miR-21, the assembly of MB-labeled HP1 and Fc-labeled HP2 leads to the generation of a large amount of double-stranded DNA (HP1- HP2), which pushes MB away from the electrode surface and brings Fc close to the electrode surface, resulting in effectively quenching the enhanced PEC signal to activate the photocurrent-polarity-switching system. Benefiting from the distance-controllable strategy, the designed PEC bioanalysis can effectively eliminate false-positive and false-negative signals due to the change of different signal expression patterns (from traditional the "signal-on " mode to the photocurrent-polarity-switching mode), thereby significantly improving the sensing specificity and sensitivity. The proposed PEC sensing system exhibited satisfying photocurrent responses toward target miR-21 within the working range from 1.0 fM to 1 nM at a low limit of detection (LOD) of 0.58 fM. More importantly, we demonstrated the successful integration of the proposed PEC biosensor with a handheld wireless device for instant detection of miR-21 concentrations in practical samples.
Keyword ：
DNA biosensor DNA biosensor microRNA-21 microRNA-21 photocurrent-polarity-switching photocurrent-polarity-switching photoelectrochemical photoelectrochemical point-of-care point-of-care
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| GB/T 7714 | Zeng, Ruijin , Xu, Jianhui , Liang, Tikai et al. Photocurrent-Polarity-Switching Photoelectrochemical Biosensor for Switching Spatial Distance Electroactive Tags [J]. | ACS SENSORS , 2023 , 8 (1) : 317-325 . |
| MLA | Zeng, Ruijin et al. "Photocurrent-Polarity-Switching Photoelectrochemical Biosensor for Switching Spatial Distance Electroactive Tags" . | ACS SENSORS 8 . 1 (2023) : 317-325 . |
| APA | Zeng, Ruijin , Xu, Jianhui , Liang, Tikai , Li, Meijin , Tang, Dianping . Photocurrent-Polarity-Switching Photoelectrochemical Biosensor for Switching Spatial Distance Electroactive Tags . | ACS SENSORS , 2023 , 8 (1) , 317-325 . |
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As a biological thiol closely related to the incidence of gastric cancer, homocysteine (Hcy) has been re-ported to be detected in vivo and in vitro . The design of ratiometric photoluminescent probes often relies on the unique chemical structure of the molecular. In this paper, we designed and synthesized three aldehyde-containing iridium(III) complexes and characterized their structure and photophysical proper-ties. They showed a good specificity for Hcy detection. The color of the solution gradually changed from red to pale yellow. The photoluminescent variation from red to green was observed by the naked eye after addition of Hcy to the solution of the Ir1 ([(CHO-pba)(2)Ir(bpy-2NH(2))]PF6), Ir2 ([(CF3-pba)(2)Ir(bpy-2NH(2))]PF6) and Ir3 ([(CH3-pba)(2)Ir(bpy-2NH(2))]PF6) with a large blue shift by 120, 63 and 106 nm, respec-tively. Based on the differences in their structures, it could be inferred that this type of ratiometric pho-toluminescent probe based on iridium(III) complexes with aldehyde was related to the strong electron -donating effect of the nitrogen-containing substituents on the bipyridine ligand in the structure, and the introduction of electron-donating groups on the 4-(2-pyridinyl)benzaldehyde (pba) ligand can enlarge the blue shift of the photoluminescent wavelength upon sensing of Hcy. On the other hand, iridium(III) com-plexes are currently recognized as a third-generation good photodynamic therapy photosensitizer. The photodynamic therapy properties of the three iridium(III) complexes in this article have also been evalu-ated. All of them have strong singlet oxygen generation ability and low cytotoxicity which are expected to be used in photodynamic therapy and Hcy detection. (C) 2022 Elsevier B.V. All rights reserved.
Keyword ：
Colorimetric photoluminescence Colorimetric photoluminescence Homocysteine sensor Homocysteine sensor Iridium(III) complexes Iridium(III) complexes Singlet oxygen Singlet oxygen
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| GB/T 7714 | Mu, Xiangjun , Zhang, Wanqing , Yi, Changqing et al. Colorimetric and photoluminescent probes based on iridium(III) complexes for highly selective detection of homocysteine [J]. | JOURNAL OF MOLECULAR STRUCTURE , 2023 , 1271 . |
| MLA | Mu, Xiangjun et al. "Colorimetric and photoluminescent probes based on iridium(III) complexes for highly selective detection of homocysteine" . | JOURNAL OF MOLECULAR STRUCTURE 1271 (2023) . |
| APA | Mu, Xiangjun , Zhang, Wanqing , Yi, Changqing , Li, Mei-Jin , Fu, Fengfu . Colorimetric and photoluminescent probes based on iridium(III) complexes for highly selective detection of homocysteine . | JOURNAL OF MOLECULAR STRUCTURE , 2023 , 1271 . |
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Anew Ir(III) complex was designed, synthesized, and characterized.Its photophysical properties and aggregation-induced emission andelectrochemiluminescence in the near-infrared range were studied.The complex was aggregated into small spherical nanoparticles in 80%water and fascinating nanorings in 90% water. The sensing of ampicillinsodium by the Ir(III) complex was also investigated based on aggregation-inducedemission and electrochemiluminescence, and it showed a good selectivitytoward ampicillin sodium antibiotic. A new iridium(III) complex was synthesized and characterized.Itsphotophysical properties and aggregation-induced emission and electrochemiluminescencein the near-infrared range were studied. The large conjugated cyclometallicligand 1,2-phenylbenzoquinoline (pbq) was selected to form the Ir-Cbond with the metal iridium(III) center and provide near-infraredemission of the complex. The auxiliary ligand 4,4 & PRIME;-diamino-2,2 & PRIME;-bipyridine(dabpy) can form hydrogen bonds, which was beneficial for the generationof aggregation-induced emission. The complex was aggregated into smallspherical nanoparticles in 80% water and fascinating nanorings in90% water. The sensing of ampicillin sodium (AMP) antibiotic by theiridium(III) complex were also investigated by photoluminescent andelectrochemiluminescent methods. The complex showed a good selectivitytoward AMP antibiotic compared to sodium phenylacetate and other eightantibiotics. The detection limits for AMP antibiotic was 0.76 & mu;g/mL.This work provided a new strategy for the design of iridium(III) complex-basedaggregation-induced emission and electrochemiluminescence probes forthe sensing application.
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| GB/T 7714 | Chen, Weibin , Qiu, Meiling , Tu, Rui et al. Aggregation-Induced Near-Infrared Emission and Electrochemiluminescence of an Iridium(III) Complex for Ampicillin Sodium Sensing [J]. | INORGANIC CHEMISTRY , 2023 , 62 (29) : 11708-11717 . |
| MLA | Chen, Weibin et al. "Aggregation-Induced Near-Infrared Emission and Electrochemiluminescence of an Iridium(III) Complex for Ampicillin Sodium Sensing" . | INORGANIC CHEMISTRY 62 . 29 (2023) : 11708-11717 . |
| APA | Chen, Weibin , Qiu, Meiling , Tu, Rui , Mu, Xiangjun , Fu, Fengfu , Li, Mei-Jin . Aggregation-Induced Near-Infrared Emission and Electrochemiluminescence of an Iridium(III) Complex for Ampicillin Sodium Sensing . | INORGANIC CHEMISTRY , 2023 , 62 (29) , 11708-11717 . |
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This work designed a liposome-mediated photocurrent polarity switching immunosensor depending on the reversed photocurrent of iodine-doped BiOCl (I-BOC) nanoflowers induced by the released methylene blue (MB) for the detection of prostate-specific antigen (PSA). Initially, MB-loaded liposomes as indicators were confined within the microplates to participate in the sandwiched immunoreaction and lysed under the treatment of Triton X-100 to release numerous MB. Owing to the host-guest recognition between beta-cyclodextrin (beta-CD) and MB, the released MB was immobilized on the beta-CD-modified I-BOC/FTO electrode and triggered the photocurrent polarity reversal from cathodic photocurrent to anodic photocurrent. The sensing platform realized an accurate and sensitive assay of PSA due to the effective elimination of false-positive/negative signals in a linear range of 0.02-50 ng mL-1 with a limit of detection of 12 pg mL-1. Furthermore, this work not only conjugated liposomeassisted signal amplification strategy with the photocurrent polarity switching system but also provided a novel pathway for various protein determinations.
Keyword ：
Iodine-doped BiOCl nanoflowers Iodine-doped BiOCl nanoflowers Low-abundance protein Low-abundance protein Methylene blue-loaded liposome Methylene blue-loaded liposome Photocurrent-polarity switching Photocurrent-polarity switching Photoelectrochemical immunoassay Photoelectrochemical immunoassay
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| GB/T 7714 | Lin, Qianyun , Lu, Liling , Huang, Xue et al. Photocurrent-polarity switching between methylene blue-loaded liposome and iodine-doped BiOCl for in-situ amplified immunoassay [J]. | TALANTA , 2023 , 268 . |
| MLA | Lin, Qianyun et al. "Photocurrent-polarity switching between methylene blue-loaded liposome and iodine-doped BiOCl for in-situ amplified immunoassay" . | TALANTA 268 (2023) . |
| APA | Lin, Qianyun , Lu, Liling , Huang, Xue , Li, Meijin , Tang, Dianping . Photocurrent-polarity switching between methylene blue-loaded liposome and iodine-doped BiOCl for in-situ amplified immunoassay . | TALANTA , 2023 , 268 . |
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