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学者姓名：汤云东
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Abstract ：
Magnetic nanoparticles (MNPs) used for magnetic hyperthermia can not only damage tumor cells after elevating to a specific temperature but also provide the temperature required for thermosensitive liposomes (TSL) to release doxorubicin (DOX). MNPs injected into tumor will generate heat under an alternating magnetic field, so the MNPs distribution can determine temperature distribution and further affect the DOX concentration used for tumor therapy. This study proposes an asynchronous injection strategy for this combination therapy in order to improve the DOX concentration value for drug therapy, in which the MNPs are injected into tumor after a certain lagging of TSL injection in order to increase the TSL concentration inside tumor. In addition, the evaluation of treatment effect for this combination therapy is implemented by considering two different MNPs concentration distributions and two biological heat transfer models. The simulation results demonstrate that the treatment effect for combination therapy can be significantly improved after considering the proposed asynchronous injection strategy, which can mainly attribute to the improvement of DOX concentration. The DOX concentration difference during therapy is generally relevant to both the lagging time of different injections and the local temperature distribution due to MNPs concentration distribution.
Keyword ：
Heat transfer Heat transfer Heat transfer model Heat transfer model Magnetic hyperthermia Magnetic hyperthermia Targeted drug delivery Targeted drug delivery Temperature-sensitive liposomes Temperature-sensitive liposomes
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| GB/T 7714 | Tang, Yundong , Zhu, Jiajia , Flesch, Rodolfo C. C. et al. Effect of proposed asynchronous injection strategy on the combination therapy of magnetic hyperthermia and thermosensitive liposome [J]. | JOURNAL OF THERMAL BIOLOGY , 2025 , 127 . |
| MLA | Tang, Yundong et al. "Effect of proposed asynchronous injection strategy on the combination therapy of magnetic hyperthermia and thermosensitive liposome" . | JOURNAL OF THERMAL BIOLOGY 127 (2025) . |
| APA | Tang, Yundong , Zhu, Jiajia , Flesch, Rodolfo C. C. , Jin, Tao . Effect of proposed asynchronous injection strategy on the combination therapy of magnetic hyperthermia and thermosensitive liposome . | JOURNAL OF THERMAL BIOLOGY , 2025 , 127 . |
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磁粒子成像(MPI)利用检测装置感应可视场内不同位置处磁纳米粒子(MNPs)的非线性磁化响应,并基于所获得的检测信号重建MNPs浓度分布.该文基于激励与接收线圈磁场强度对检测信号的影响,论证了X-space和投影重建成像算法中MPI检测装置磁场均匀性的重要性,继而提出一种由具有较高磁场均匀性的正方形亥姆霍兹线圈所构成的改进开放式检测装置.此外,在零磁场点和零磁场线扫描移动两种情况下,基于不同装置下均匀分布MNPs所获得的检测信号,评估了两种传统开放式检测装置和所提改进装置的检测效果.研究结果表明,所提改进开放式装置的检测结果相比两种传统开放式装置显著接近理想情况,进而也证实了检测装置磁场均匀性的重要性.此外,该文还发现在改进装置基础上采用二次谐波检测方法相较于三次谐波检测,可获得更佳的检测效果.
Keyword ：
开放式检测装置 开放式检测装置 检测信号 检测信号 正方形亥姆霍兹线圈 正方形亥姆霍兹线圈 磁场均匀性 磁场均匀性 磁粒子成像 磁粒子成像
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| GB/T 7714 | 汤云东 , 丁宇彬 , 金涛 . 考虑磁场均匀性优化的开放式磁粒子成像检测装置改进方法 [J]. | 电工技术学报 , 2025 , 40 (6) : 1718-1728 . |
| MLA | 汤云东 et al. "考虑磁场均匀性优化的开放式磁粒子成像检测装置改进方法" . | 电工技术学报 40 . 6 (2025) : 1718-1728 . |
| APA | 汤云东 , 丁宇彬 , 金涛 . 考虑磁场均匀性优化的开放式磁粒子成像检测装置改进方法 . | 电工技术学报 , 2025 , 40 (6) , 1718-1728 . |
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Although deep convolutional neural network (CNN) has been widely used in the breast cancer detection based on thermal imaging technology, this scenario still did not receive enough attention in the mobile devices with limited resource. In addition, there still exists challenge on how to assist front view thermal imaging by side one during breast cancer detection. This study proposes a multi-input lightweight CNN named Multi-light Net in order to achieve more accurate early detection for breast cancer, which combines the thermal image from multiple perspectives with the lightweight CNN on the basis of model performance and scale. In addition, a new weighted label smoothing regularization (WLSR) is proposed for the Multi-light Net with the purpose of increasing the network's generalization ability and classification accuracy. The experimental results demonstrate that the proposed approach by combining front view with side view can achieve more significant results than the common one using only front view during breast cancer detection, and the proposed Multi-light Net also exhibits an excellent performance with respect to the currently popular lightweight CNN. Furthermore, the proposed WLSR loss function can also lead to both faster convergence rate and more stable training process during network training and ultimately higher diagnostic accuracy for breast cancer.
Keyword ：
Breast cancer Breast cancer CNN CNN Lightweight Lightweight Multi-input Multi-input Thermography Thermography
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| GB/T 7714 | Tang, Yundong , Zhou, Depei , Flesch, Rodolfo C. C. et al. A multi-input lightweight convolutional neural network for breast cancer detection considering infrared thermography [J]. | EXPERT SYSTEMS WITH APPLICATIONS , 2025 , 263 . |
| MLA | Tang, Yundong et al. "A multi-input lightweight convolutional neural network for breast cancer detection considering infrared thermography" . | EXPERT SYSTEMS WITH APPLICATIONS 263 (2025) . |
| APA | Tang, Yundong , Zhou, Depei , Flesch, Rodolfo C. C. , Jin, Tao . A multi-input lightweight convolutional neural network for breast cancer detection considering infrared thermography . | EXPERT SYSTEMS WITH APPLICATIONS , 2025 , 263 . |
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Magnetic hyperthermia damages malignant tissue by the temperature elevation to a specific value, which is one of most popular treatment methods due to its safety with respect to other traditional ways. Magnetic nanoparticles (MNPs) with nanoscale size release the heat for bio-tissue according to Rosensweig' theory when subjected to an alternating magnetic field. Previous reports mainly focused on the magnetic field in a relatively enclosed space, which however generally has some limitation on the placement of larger volume target and can lead to the inhomogeneous distribution due to the increase of internal space. This study establishes an open magnetic field device for magnetic hyperthermia, which is evaluated by the treatment effect of a simple rat model. Further, this device is also optimized by considering the radius of planar coil and by introducing a PID controller with adjusted parameters. After using finite element method for corresponding partial differential equations, the magnetic field profile for the proposed planar coil obtained is sequentially coupled with the temperature field distribution of biological tissue. The results demonstrate that the planar coil with more rings can result in a better scenario for magnetic hyperthermia with respect to less rings case to some extent. In addition, the proposed PID controller can be used to improve the thermal damage of malignant tissue by decreasing both the setting time and the overshoot for spatiotemporal temperature during therapy.
Keyword ：
Magnetic field device Magnetic field device Magnetic hyperthermia Magnetic hyperthermia Open magnetic field Open magnetic field Planar coils Planar coils Temperature field Temperature field
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| GB/T 7714 | Tang, Yundong , Flesch, Rodolfo C. C. , Jin, Tao . Optimization approach for complete magnetic hyperthermia model considering open magnetic field device [J]. | JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS , 2025 , 629 . |
| MLA | Tang, Yundong et al. "Optimization approach for complete magnetic hyperthermia model considering open magnetic field device" . | JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 629 (2025) . |
| APA | Tang, Yundong , Flesch, Rodolfo C. C. , Jin, Tao . Optimization approach for complete magnetic hyperthermia model considering open magnetic field device . | JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS , 2025 , 629 . |
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In view of the problem of too idealized modeling for magnetic nanoparticles，a variety of monodisperse and polydisperse magnetic nanoparticles (MNPs) distributions were constructed for a proposed tumor model．On this basis，the treatment temperature for the proposed model was predicted by solving the biological heat transfer equation after taking the power consumption of MNPs as the input，and the therapeutic effect differences due to different dispersed MNPs during magnetic hyperthermia were further investigated． In addition，a fuzzy adaptive proportional-integral-differential control system for magnetic hyperthermia was constructed after considering a more real distribution for polydisperse MNPs． This system can accurately control the treatment temperature within a critical value (46°C) by temperature feedback during magnetic hyperthermia，which solves the problem that the local temperature of target area is difficult to stabilize at the optimal safe treatment temperature due to the inhomogeneous distribution and polydispersity of MNPs．The simulation results demonstrate that the treatment effect can be improved by increasing the aggregation degree of MNPs size and the uniformity of MNPs distribution in the tumor area under the same treatment conditions．Furthermore，the control system proposed can significantly improve the treatment effect by quickly stabilizing the maximum temperature to an optimal value，46°C． © 2024 Huazhong University of Science and Technology. All rights reserved.
Keyword ：
Adaptive control systems Adaptive control systems Heat transfer Heat transfer Hyperthermia therapy Hyperthermia therapy Particle size Particle size Particle size analysis Particle size analysis Polydispersity Polydispersity Proportional control systems Proportional control systems Tumors Tumors Two term control systems Two term control systems
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| GB/T 7714 | Tang, Yundong , Chen, Ming , Jin, Tao . Evaluation and optimization for temperature distribution in magnetic hyperthermia considering particle dispersion [J]. | Journal of Huazhong University of Science and Technology (Natural Science Edition) , 2024 , 52 (3) : 65-71 . |
| MLA | Tang, Yundong et al. "Evaluation and optimization for temperature distribution in magnetic hyperthermia considering particle dispersion" . | Journal of Huazhong University of Science and Technology (Natural Science Edition) 52 . 3 (2024) : 65-71 . |
| APA | Tang, Yundong , Chen, Ming , Jin, Tao . Evaluation and optimization for temperature distribution in magnetic hyperthermia considering particle dispersion . | Journal of Huazhong University of Science and Technology (Natural Science Edition) , 2024 , 52 (3) , 65-71 . |
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The combination therapy of magnetic hyperthermia and thermosensitive liposomes (TSL) is an emerging and effective cancer treatment method. The heat generation of magnetic nanoparticles (MNPs) due to an external alternating magnetic field can not only directly damage tumor cells, but also serves as a triggering factor for the release of doxorubicin from TSL. The aim of this study is to investigate the effects in the degree of tumor cell damage of two proposed injection strategies that consider intravenous administration. Since both MNPs and TSL enter the tumor region intravenously, this study establishes a biological geometric model based on an experiment-based vascular distribution. Furthermore, this study derives the flow velocity of interstitial fluid after coupling the pressure distribution inside blood vessels and the pressure distribution of interstitial fluid, which then provides the convective velocity for the calculation of subsequent nanoparticle concentration. Different injection strategies for the proposed approach are evaluated by drug delivery result, temperature distribution, and tumor cell damage. Simulation results demonstrate that the proposed delayed injection strategy after optimization can not only result in a wider distribution for MNPs and TSL due to the sufficient diffusion time, but also improves the distribution of the temperature and drug concentration fields for the overall efficacy of combination therapy.
Keyword ：
44.05.+e 44.05.+e 44.10.+i 44.10.+i 87.85.J- 87.85.J- injection strategy injection strategy intravenous injection intravenous injection magnetic hyperthermia magnetic hyperthermia temperature-sensitive liposomes temperature-sensitive liposomes
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| GB/T 7714 | Zhu, Jiajia , Tang, Yundong , Flesch, Rodolfo C. C. et al. Effect of different injection strategies considering intravenous injection on combination therapy of magnetic hyperthermia and thermosensitive liposomes [J]. | CHINESE PHYSICS B , 2024 , 33 (12) . |
| MLA | Zhu, Jiajia et al. "Effect of different injection strategies considering intravenous injection on combination therapy of magnetic hyperthermia and thermosensitive liposomes" . | CHINESE PHYSICS B 33 . 12 (2024) . |
| APA | Zhu, Jiajia , Tang, Yundong , Flesch, Rodolfo C. C. , Jin, Tao . Effect of different injection strategies considering intravenous injection on combination therapy of magnetic hyperthermia and thermosensitive liposomes . | CHINESE PHYSICS B , 2024 , 33 (12) . |
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Magnetic particle imaging (MPI) technology can generate a real-time magnetic nanoparticle (MNP) distribution image for biological tissues, and its use can overcome the limitations imposed in magnetic hyperthermia treatments by the unpredictable MNP distribution after the intratumoral injection of nanofluid. However, the MNP concentration distribution is generally difficult to be extracted from MPI images. This study proposes an approach to extract the corresponding concentration value of each pixel from an MPI image by a least squares method (LSM), which is then translated as MNP concentration distribution by an interpolation function. The resulting MPI-based concentration distribution is used to evaluate the treatment effect and the results are compared with the ones of two baseline cases under the same dose: uniform distribution and MPI-based distribution considering diffusion. Additionally, the treatment effect for all these cases is affected by the blood perfusion rate, which is also investigated deeply in this study. The results demonstrate that the proposed method can be used to effectively reconstruct the concentration distribution from MPI images, and that the weighted LSM considering a quartic polynomial for interpolation provides the best results with respect to other cases considered. Furthermore, the results show that the uniformity of MNP distribution has a positive correlation with both therapeutic temperature distribution and thermal damage degree for the same dose and a critical power dissipation value in the MNPs. The MNPs uniformity inside biological tissue can be improved by the diffusion behavior after the nanofluid injection, which can ultimately reflect as an improvement of treatment effect. In addition, the blood perfusion rate considering local temperature can have a positive effect on the treatment compared to the case which considers a constant value during magnetic hyperthermia.
Keyword ：
44.05.+e 44.05.+e 44.10.+i 44.10.+i 87.85.J- 87.85.J- blood perfusion rate blood perfusion rate magnetic hyperthermia magnetic hyperthermia magnetic nanoparticles distribution magnetic nanoparticles distribution thermal damage thermal damage
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| GB/T 7714 | Tang, Yundong , Chen, Ming , Flesch, Rodolfo C. C. et al. Extraction method of nanoparticles concentration distribution from magnetic particle image and its application in thermal damage of magnetic hyperthermia [J]. | CHINESE PHYSICS B , 2023 , 32 (9) . |
| MLA | Tang, Yundong et al. "Extraction method of nanoparticles concentration distribution from magnetic particle image and its application in thermal damage of magnetic hyperthermia" . | CHINESE PHYSICS B 32 . 9 (2023) . |
| APA | Tang, Yundong , Chen, Ming , Flesch, Rodolfo C. C. , Jin, Tao . Extraction method of nanoparticles concentration distribution from magnetic particle image and its application in thermal damage of magnetic hyperthermia . | CHINESE PHYSICS B , 2023 , 32 (9) . |
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Magnetic particle imaging(MPI)technology can generate a real-time magnetic nanoparticle(MNP)distribution im-age for biological tissues,and its use can overcome the limitations imposed in magnetic hyperthermia treatments by the unpredictable MNP distribution after the intratumoral injection of nanofluid.However,the MNP concentration distribu-tion is generally difficult to be extracted from MPI images.This study proposes an approach to extract the corresponding concentration value of each pixel from an MPI image by a least squares method(LSM),which is then translated as MNP concentration distribution by an interpolation function.The resulting MPI-based concentration distribution is used to eval-uate the treatment effect and the results are compared with the ones of two baseline cases under the same dose:uniform distribution and MPI-based distribution considering diffusion.Additionally,the treatment effect for all these cases is af-fected by the blood perfusion rate,which is also investigated deeply in this study.The results demonstrate that the proposed method can be used to effectively reconstruct the concentration distribution from MPI images,and that the weighted LSM considering a quartic polynomial for interpolation provides the best results with respect to other cases considered.Further-more,the results show that the uniformity of MNP distribution has a positive correlation with both therapeutic temperature distribution and thermal damage degree for the same dose and a critical power dissipation value in the MNPs.The MNPs uniformity inside biological tissue can be improved by the diffusion behavior after the nanofluid injection,which can ulti-mately reflect as an improvement of treatment effect.In addition,the blood perfusion rate considering local temperature can have a positive effect on the treatment compared to the case which considers a constant value during magnetic hyperthermia.
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| GB/T 7714 | Yundong Tang , Ming Chen , Rodolfo C.C.Flesch et al. Extraction method of nanoparticles concentration distribution from magnetic particle image and its application in thermal damage of magnetic hyperthermia [J]. | 中国物理B（英文版） , 2023 , 32 (9) : 344-352 . |
| MLA | Yundong Tang et al. "Extraction method of nanoparticles concentration distribution from magnetic particle image and its application in thermal damage of magnetic hyperthermia" . | 中国物理B（英文版） 32 . 9 (2023) : 344-352 . |
| APA | Yundong Tang , Ming Chen , Rodolfo C.C.Flesch , Tao Jin . Extraction method of nanoparticles concentration distribution from magnetic particle image and its application in thermal damage of magnetic hyperthermia . | 中国物理B（英文版） , 2023 , 32 (9) , 344-352 . |
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该文研究了两种常见亥姆霍兹线圈产生磁场的均匀性,并根据装置线圈所产生磁场作用下的生物组织治疗温度分布分析了磁场均匀性对治疗效果的影响.其中,文中的磁纳米粒子(MNPs)以磁流体形式注射进肿瘤区域并假定以注射点为中心呈现高斯分布.该文在多种约束条件下应用改进粒子群算法优化了磁场的频率和强度、磁纳米粒子粒径,以及磁纳米粒子体积分数等参数,而涉及的约束条件包括治疗最高安全温度、治疗磁场安全范围上限、MNPs粒径范围,以及MNPs产热有效条件等.同时,该文以累积等效分钟数来评估圆形和正方形亥姆霍兹线圈及理想磁场在不同血液灌注率下的细胞热损伤程度.研究结果表明,正方形亥姆霍兹线圈相比于圆形线圈能产生更大范围的匀强磁场,这使其磁热疗效果更接近于理想磁场情况.同时,考虑温度依赖的血液灌注率相比定值情况具有更高的治疗温度.
Keyword ：
亥姆霍兹线圈 亥姆霍兹线圈 温度场 温度场 磁场 磁场 磁热疗 磁热疗 粒子群优化算法 粒子群优化算法 血液灌注率 血液灌注率
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| GB/T 7714 | 汤云东 , 丁宇彬 , 金涛 . 基于亥姆霍兹线圈装置的磁热疗优化方法 [J]. | 电工技术学报 , 2023 , 38 (5) : 1248-1260 . |
| MLA | 汤云东 et al. "基于亥姆霍兹线圈装置的磁热疗优化方法" . | 电工技术学报 38 . 5 (2023) : 1248-1260 . |
| APA | 汤云东 , 丁宇彬 , 金涛 . 基于亥姆霍兹线圈装置的磁热疗优化方法 . | 电工技术学报 , 2023 , 38 (5) , 1248-1260 . |
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Magnetic nanofluid hyperthermia (MNH) damages malignant cells by the heat generated by magnetic nanoparticles (MNPs) exposed to an alternating magnetic field during therapy. The key point for magnetic hyperthermia is to maintain the treatment temperature to a safe range for bio-tissue, in which malignant tissue will be damaged due to its higher heat sensitivity but not the healthy tissue. However, the therapeutic system for MNH should be a nonlinear one since the treatment temperature is generally determined by many certain and uncertain factors, which result in the difficulty to modulate the temperature to a specific range in a practical application. This study proposes a control method for an MNH system by introducing a proportional-integral-derivative (PID) control algorithm and dynamically optimizes the PID coefficients for the proposed system by considering simulated annealing (SA) algorithm during therapy. The treatment temperature distribution for bio-tissue is obtained by solving an improved Pennes bio-heat transfer equation using finite element method (FEM). The simulation results demonstrate that the proposed control system can effectively modulate the power dissipation for MNPs and further exactly regulate the transient treatment temperature to an expected value. In addition, this proposed system can also automatically adapt to different cases during therapy, in which the nanofluid concentration distribution inside tumor region changes with nanofluid injection strategy.
Keyword ：
Control method Control method magnetic hyperthermia magnetic hyperthermia proportional-integral-derivative (PID) proportional-integral-derivative (PID) simulated annealing (SA) algorithm simulated annealing (SA) algorithm
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| GB/T 7714 | Tang, Yundong , Su, Hang , Jin, Tao et al. Adaptive PID Control Approach Considering Simulated Annealing Algorithm for Thermal Damage of Brain Tumor During Magnetic Hyperthermia [J]. | IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT , 2023 , 72 . |
| MLA | Tang, Yundong et al. "Adaptive PID Control Approach Considering Simulated Annealing Algorithm for Thermal Damage of Brain Tumor During Magnetic Hyperthermia" . | IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT 72 (2023) . |
| APA | Tang, Yundong , Su, Hang , Jin, Tao , Flesch, Rodolfo Cesar Costa . Adaptive PID Control Approach Considering Simulated Annealing Algorithm for Thermal Damage of Brain Tumor During Magnetic Hyperthermia . | IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT , 2023 , 72 . |
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