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学者姓名：陈旭
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Abstract ：
The effect of digestion on nanocarriers will affect the release and pharmacological effects of bioactive compounds in delivery systems. The digestion of cellulose is limited to gut microbiota, which offers a new research strategy for targeted delivery of bioactive compounds. Herein, positively charged cellulose-like chitosan/polyvinylpyrrolidone nanofiber was prepared to improve the residence time, colon target and gut microbiota regulation activity of quercetin decorated selenium nanoparticles (QUE@SeNPs/CS/PVPNFs). Selenium nanoparticles block the degradation of quercetin and QUE@SeNPs/CS/PVPNFs only decompose when caused by chitosanase secretion from gut microbiota. In vivo imaging showed that the residence time of QUE@SeNPs/CS/ PVPNFs was longer than that of QUE@SeNPs. Thus, it significantly decreased the lipid concentrations in liver, which further inhibited insulin resistance in mice. Moreover, QUE@SeNPs/CS/PVPNFs treatment improves gut barrier integrity, increased the relative abundance of anti-obesity and anti-inflammation related bacterial including Akkermansia, Lactobacillus and Bacteroides. Consequently, the inflammatory factor (IL-beta and TNF-alpha) levels in gut, liver and brain were also decreased. Nissl and PSD-95 staining indicated that QUE@SeNPs/CS/ PVPNFs ameliorated synapse dysfunction in the brain. Therefore, QUE@SeNPs/CS/PVPNFs has a greater effect than QUE@SeNPs in improving cognitive ability in Morris water maze. Overall, QUE@SeNPs/CS/PVPNFs with prolonged residence time attenuates cognitive disorder via gut-liver-brain axis in AD.
Keyword ：
Alzheimer's disease Alzheimer's disease Chitosan Chitosan Gut-liver-brain axis Gut-liver-brain axis Obesity Obesity Quercetin modified selenium nanoparticles Quercetin modified selenium nanoparticles
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| GB/T 7714 | Fang, Chaoping , Chen, Qingchang , Zheng, Guodong et al. Cellulose-like chitosan microfibrils facilitate targeted release and enhance the prolonged residence time of quercetin-selenium nanoparticles for Alzheimer's disease treatment [J]. | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2025 , 670 . |
| MLA | Fang, Chaoping et al. "Cellulose-like chitosan microfibrils facilitate targeted release and enhance the prolonged residence time of quercetin-selenium nanoparticles for Alzheimer's disease treatment" . | INTERNATIONAL JOURNAL OF PHARMACEUTICS 670 (2025) . |
| APA | Fang, Chaoping , Chen, Qingchang , Zheng, Guodong , Zhang, Fang , Li, Zhiwei , Mei, Jingtao et al. Cellulose-like chitosan microfibrils facilitate targeted release and enhance the prolonged residence time of quercetin-selenium nanoparticles for Alzheimer's disease treatment . | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2025 , 670 . |
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This study assessed the effects of antifreeze peptides (CsAFPs) produced by enzymatical hydrolysis of chicken skin on chicken mince stability. CsAFPs, 85.88% of which were short peptides (180–3 000 Da), showed high hydrophilicity and strong thermal hysteresis activity and ice recrystallization inhibition activity, reducing the ice crystal content by (26.03 ± 0.40)% and raising the glass transition temperature by 7.3 ℃. The flavor of CsAFPs was well coordinated with that of chicken mince and the addition of 2% CsAFPs enhanced the water-holding capacity of chicken mince without color change. After four freeze-thaw cycles, mince added with 2% CsAFPs showed less reductions in water-holding capacity, elasticity, and resilience than did the control group. Ultraviolet (UV) absorption and Fourier transform infrared spectroscopy (FTIR) indicated that CsAFPs could prevent the aggregation and denaturation of proteins under freezing stress. After freeze-thaw cycles, the r value of myofibrillar protein in the mince with 2% added CsAFPs was higher than the control group without CsAFPs. This study contributes to a better understanding of the protective mechanisms of CsAFPs in frozen meat and highlights that CsAFPs are promising novel low-sweetness and low-calorie cryoprotectants for meat products. © 2025 Chinese Chamber of Commerce. All rights reserved.
Keyword ：
Beef Beef Enzymatic hydrolysis Enzymatic hydrolysis Fourier transform infrared spectroscopy Fourier transform infrared spectroscopy Freezing Freezing Peptides Peptides Poultry Poultry Thawing Thawing
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| GB/T 7714 | Cai, Dongna , Du, Shuang , Jiang, Wenting et al. Chicken Skin Antifreeze Peptides: Ice Crystal Inhibition Activity and Quality Control of Chicken Mince during Freeze-Thaw Cycles [J]. | Food Science , 2025 , 46 (9) : 91-99 . |
| MLA | Cai, Dongna et al. "Chicken Skin Antifreeze Peptides: Ice Crystal Inhibition Activity and Quality Control of Chicken Mince during Freeze-Thaw Cycles" . | Food Science 46 . 9 (2025) : 91-99 . |
| APA | Cai, Dongna , Du, Shuang , Jiang, Wenting , Bu, Shuai , Yang, Ao , Wang, Shaoyun et al. Chicken Skin Antifreeze Peptides: Ice Crystal Inhibition Activity and Quality Control of Chicken Mince during Freeze-Thaw Cycles . | Food Science , 2025 , 46 (9) , 91-99 . |
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Traditional cryoprotectants such as sucrose and phosphates are limited by safety and flavor concerns, creating a demand for food-grade alternatives. Here, Bos taurus domesticus gelatin antifreeze peptides (BtAFP) were investigated for their dual cryoprotective mechanisms. Rheological analysis showed that BtAFP enhanced gel elasticity and delayed freezing, exhibiting superior cryoprotection compared with bovine serum albumin. LC-MS/MS identified 452 peptides, from which five nontoxic collagen-derived candidates with amphiphilic alpha-helix/beta-sheet motifs were selected. Ice recrystallization assays showed that the majority of ice crystals in purified peptide solutions were concentrated below 1000 mu m2. Differential scanning calorimetry indicated that GKEAFP, GLPAFP, and GLRAFP most effectively inhibited ice growth. Molecular docking demonstrated stable peptide-ice and peptide-alpha-lactalbumin interactions, with GLPAFP notably stabilizing protein structures through extensive hydrogen bonding and surface interactions. These findings suggest that gelatin-derived antifreeze peptides suppress ice recrystallization and stabilize proteins via amphiphilic ice-binding motifs, providing promising natural cryoprotectants for frozen food applications.
Keyword ：
antifreeze mechanism antifreeze mechanism antifreeze peptides antifreeze peptides cryopreservation cryopreservation structure-activityrelationship structure-activityrelationship
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| GB/T 7714 | Jiang, Wenting , Cai, Dongna , Wu, Manman et al. Unraveling the Cryoprotective Molecular Mechanisms of Antifreeze Peptides: New Insights from Simultaneous Interactions with Ice Crystals and Lactalbumin Proteins [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (38) : 24427-24436 . |
| MLA | Jiang, Wenting et al. "Unraveling the Cryoprotective Molecular Mechanisms of Antifreeze Peptides: New Insights from Simultaneous Interactions with Ice Crystals and Lactalbumin Proteins" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73 . 38 (2025) : 24427-24436 . |
| APA | Jiang, Wenting , Cai, Dongna , Wu, Manman , Chen, Xu , Cai, Xixi , Wang, Shaoyun . Unraveling the Cryoprotective Molecular Mechanisms of Antifreeze Peptides: New Insights from Simultaneous Interactions with Ice Crystals and Lactalbumin Proteins . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (38) , 24427-24436 . |
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Developing emulsifier-free intelligent films constitutes a dependable strategy for securing food supply chain safety. Here, zinc-binding peptides derived from Crimson Snapper scales (CSSP-Zn) and Jufeng grape pomace anthocyanin (JGA) were incorporated into a gelatin (GL) matrix to fabricate three types of films: GL film, GL film with CSSP-Zn and GL film with both JGA and CSSP-Zn. The GL film is a pure GL film, while the GL film incorporating CSSP-Zn exhibits antimicrobial activity, and the GL film containing both JGA and CSSP-Zn functions as an antimicrobial, pH-responsive intelligent film. Compared with the pure GL film, incorporating CSSP-Zn and JGA enhanced mechanical strength, water resistance and barrier properties via hydrogen bonding and Zn2+ ligand interactions. The intelligent film exhibited long-lasting antimicrobial activity, maintaining potent microbicidal efficacy even after 3 months of storage. Additionally, it demonstrates excellent antioxidant properties (DPPH and ABTS scavenging rates > 83 %), pH-responsive color changes, cytocompatibility (cell viability > 80 %) and biodegradability (degradable within 15 days in soil). When applied to Penaeus orientalis, the intelligent film effectively shields the shrimp from UV light, free radicals and microbes, delaying melanosis and spoilage while preserving texture, sensory attributes and nutrient profile, ultimately extending shelf life. Overall, incorporating CSSP-Zn and JGA can prepare a high-performance, eco-friendly GL-based intelligent film, providing valuable insights for sustainable food packaging. © 2025
Keyword ：
Acetobacter Acetobacter Aerobic bacteria Aerobic bacteria Bacillus cereus Bacillus cereus Environmental management systems Environmental management systems Listeria Listeria MERS MERS SARS SARS Vitamins Vitamins
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| GB/T 7714 | Lin, Shuhua , Shen, Jiaping , Zheng, Shuhong et al. Emulsifier-free gelatin-based intelligent films with long-term antimicrobial and antioxidative activities [J]. | Food Hydrocolloids , 2025 , 168 . |
| MLA | Lin, Shuhua et al. "Emulsifier-free gelatin-based intelligent films with long-term antimicrobial and antioxidative activities" . | Food Hydrocolloids 168 (2025) . |
| APA | Lin, Shuhua , Shen, Jiaping , Zheng, Shuhong , Zheng, Xingli , Chen, Xu , Cai, Xixi et al. Emulsifier-free gelatin-based intelligent films with long-term antimicrobial and antioxidative activities . | Food Hydrocolloids , 2025 , 168 . |
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| GB/T 7714 | Chen, Xu , Wu, Jinhong , Yang, Fujia et al. New insight into the mechanism by which antifreeze peptides regulate the physiological function of Streptococcus thermophilus subjected to freezing stress (vol 45, pg 127, 2023) [J]. | JOURNAL OF ADVANCED RESEARCH , 2024 , 56 : 181-181 . |
| MLA | Chen, Xu et al. "New insight into the mechanism by which antifreeze peptides regulate the physiological function of Streptococcus thermophilus subjected to freezing stress (vol 45, pg 127, 2023)" . | JOURNAL OF ADVANCED RESEARCH 56 (2024) : 181-181 . |
| APA | Chen, Xu , Wu, Jinhong , Yang, Fujia , Zhou, Mi , Wang, Ruibin , Huang, Jianlian et al. New insight into the mechanism by which antifreeze peptides regulate the physiological function of Streptococcus thermophilus subjected to freezing stress (vol 45, pg 127, 2023) . | JOURNAL OF ADVANCED RESEARCH , 2024 , 56 , 181-181 . |
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Strategies aimed at defining, discovering, and developing alternatives to traditional antibiotics will underlie the development of sustainable agricultural systems. Among such strategies, antimicrobial peptides (AMPs) with broad-spectrum antimicrobial activity and multifaceted mechanisms of action are recognized as ideal alternatives in the post-antibiotic era. In particular, AMPs derived from microbes with active metabolisms that can adapt to a variety of extreme environments have long been sought after. Consequently, this review summarizes information on naturally occurring AMPs, including their biological activity, antimicrobial mechanisms, and the preparation of microbial-derived AMPs; it also outlines their applications and the challenges presented by their use in the agroindustry. By dissecting the research results on microbial-derived AMPs of previous generations, this study contributes valuable knowledge on the exploration and realization of the applications of AMPs in sustainable agriculture. (c) 2022 THE AUTHORS. Published by Elsevier LTD on behalf of Chinese Academy of Engineering and Higher Education Press Limited Company. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keyword ：
Antibiotic alternatives Antibiotic alternatives Microbial-derived AMPs Microbial-derived AMPs Sustainable agricultural systems Sustainable agricultural systems
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| GB/T 7714 | Lin, Shuhua , Chen, Xuan , Chen, Huimin et al. The Bioprospecting of Microbial-Derived Antimicrobial Peptides for Sustainable Agriculture [J]. | ENGINEERING , 2024 , 27 : 222-233 . |
| MLA | Lin, Shuhua et al. "The Bioprospecting of Microbial-Derived Antimicrobial Peptides for Sustainable Agriculture" . | ENGINEERING 27 (2024) : 222-233 . |
| APA | Lin, Shuhua , Chen, Xuan , Chen, Huimin , Cai, Xixi , Chen, Xu , Wang, Shaoyun . The Bioprospecting of Microbial-Derived Antimicrobial Peptides for Sustainable Agriculture . | ENGINEERING , 2024 , 27 , 222-233 . |
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Fatigue is a common health issue in today's society worldwide. Finding anti-fatigue functional substances seems warranted to alleviate fatigue-related issues. The Lateolabrax japonicus peptides (LPH) obtained via enzymatic hydrolysis were identified being rich in Glu, Gly, and hydrophobic amino acids, which exhibited antioxidant properties. However, other biological functions of LPH have yet to be reported. This study main goal was to investigate the anti-fatigue effects of LPH via a fatigue mice model, and further to elucidate its underlying mechanism using in vivo assay. The results indicated that LPH exhibited strong antioxidant activity and stability in vitro. Meanwhile, LPH significantly extended the swimming time of mice, while also decreasing fatigue marker levels (LA, BUN, CK, and MDA) in serum concurrently by increased levels of antioxidant enzymes, blood glucose, and Na+-K+-ATPase. Histopathological examination revealed that LPH effectively improved tissue damage caused by fatigue. Mechanistically, LPH upregulated the gene and protein expression of Nrf2 and AMPK, indicating its regulatory role in Keap1/Nrf2 and AMPK/SIRT1/PGC-1 alpha/NRF1 signaling pathways. Furthermore, the study demonstrated that LPH could modulate the abundance and balance of fatigue-related gut microbiota (Butyricimonas, Helicobacter, Monoglobus, and Turicibacter). In summary, these findings indicated that LPH exerted its anti-fatigue effect by improving energy metabolism and reducing oxidative stress, suggesting its potential as a promising functional anti-fatigue nutraceutical in food industry.
Keyword ：
Anti -fatigue Anti -fatigue Antioxidant Antioxidant Gut microbiota Gut microbiota Lateolabrax japonicus Lateolabrax japonicus Oxidative stress Oxidative stress Peptides Peptides
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| GB/T 7714 | Li, Chen , Li, Lichan , Cheng, Jing et al. Anti-fatigue effect of Lateolabrax japonicus peptides in mice and the underlying action mechanism via in vitro and in vivo assays [J]. | FOOD BIOSCIENCE , 2024 , 58 . |
| MLA | Li, Chen et al. "Anti-fatigue effect of Lateolabrax japonicus peptides in mice and the underlying action mechanism via in vitro and in vivo assays" . | FOOD BIOSCIENCE 58 (2024) . |
| APA | Li, Chen , Li, Lichan , Cheng, Jing , Chen, Xu , Yuan, Yi , Farag, Mohamed A. et al. Anti-fatigue effect of Lateolabrax japonicus peptides in mice and the underlying action mechanism via in vitro and in vivo assays . | FOOD BIOSCIENCE , 2024 , 58 . |
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Pidan is an original traditional food in China, which has attracted extensive attention of researchers because of its unique color, fragrance, taste and functions of clearing heat, purging fire, reducing inflammation. Metallic compounds, alkali concentration, and temperature are important in the process of gel formation. Although many studies related to Pidan have been published, there is no systematic summary on the formation mechanism of gel and flavor profile. In this paper, the regulation mechanism of metal compounds in alkaline solutions, and the formation mechanism of gel, color, flavor profile, and Songhua are systematically and comprehensively reviewed to provide theoretical support for the production development and processing of Pidan. © 2024 Editorial Department of Science and Technology of Food Science. All rights reserved.
Keyword ：
Color Color Flavor compounds Flavor compounds Metal ions Metal ions
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| GB/T 7714 | Cheng, Jing , Li, Lichan , Chen, Xu et al. Formation Mechanism of Gel and Flavor during Pidan Processing [J]. | Science and Technology of Food Industry , 2024 , 45 (5) : 357-366 . |
| MLA | Cheng, Jing et al. "Formation Mechanism of Gel and Flavor during Pidan Processing" . | Science and Technology of Food Industry 45 . 5 (2024) : 357-366 . |
| APA | Cheng, Jing , Li, Lichan , Chen, Xu , Cai, Xixi , Yu, Jie , Yu, Liyang et al. Formation Mechanism of Gel and Flavor during Pidan Processing . | Science and Technology of Food Industry , 2024 , 45 (5) , 357-366 . |
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以鸡皮为原料,通过超声酶解法制备鸡皮蛋白抗冻肽(chicken skin antifreeze peptides,CsAFPs).在单因素实验的基础上,采用响应面法优化酶解工艺以制备CsAFPs.测定CsAFPs的肽组分、氨基酸组成,并评估其对鸡肉油墨3D打印效果的影响.实验结果表明,最适酶解条件为料液比(鸡皮质量与蒸馏水体积比)为1∶5,酶底比(碱性蛋白酶与鸡皮质量比)为5.69％,酶解时间为3.43h,酶解温度为50℃.在该条件下嗜热链球菌冻融后的存活率为(81.45±1.48)％.CsAFPs的肽组分中多肽的质量分数为(91.65±1.71)％,氨基酸组成分析显示CsAFPs富含Gly,Pro,Arg,Hypro,Ala,Glu等与抗冻活性相关的氨基酸残基.当所添加CsAFPs的质量分数为2.0％时,鸡肉油墨的3D打印效果最好.
Keyword ：
3D打印 3D打印 抗冻 抗冻 胶原蛋白肽 胶原蛋白肽 鸡皮 鸡皮 鸡肉油墨 鸡肉油墨
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| GB/T 7714 | 郭立 , 陈旭 , 田韩 et al. 鸡皮蛋白抗冻肽的优化制备及其对鸡肉糜3D打印性能的影响 [J]. | 福州大学学报（自然科学版） , 2024 , 52 (5) : 627-634 . |
| MLA | 郭立 et al. "鸡皮蛋白抗冻肽的优化制备及其对鸡肉糜3D打印性能的影响" . | 福州大学学报（自然科学版） 52 . 5 (2024) : 627-634 . |
| APA | 郭立 , 陈旭 , 田韩 , 陈友康 , 蔡茜茜 , 汪少芸 . 鸡皮蛋白抗冻肽的优化制备及其对鸡肉糜3D打印性能的影响 . | 福州大学学报（自然科学版） , 2024 , 52 (5) , 627-634 . |
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Nuciferine exhibits properties such as reducing blood sugar and fat, however, it is hindered by its poor water solubility and low bioavailability. Pickering emulsions can efficiently encapsulate, protect and deliver active ingredients. In recent years, the use of biologically derived natural materials as emulsifiers to construct Pickering emulsions has become a research hotspot. This research utilized an enzymatic hydrolysis technique to produce short amylose. Subsequently, a ternary composite of short amylose (DBS), zein, and pectin (PEC) was formulated to stabilize Pickering emulsion, with the incorporation of nuciferine aiming to enhance the performance of lotus leaves in terms of both stability and bioavailability. The study revealed that varying amounts of DBS addition had a significant impact on the micromorphological structure and functional properties of DBS-Zein-PEC ternary composite particles. Specifically, the addition of 0.4 g of DBS led to a notable reduction in particle size to 735.2 nm and Zeta potential to -29.6 mV, creating a three-dimensional network with a closely packed lamellar structure. Optimal process conditions for preparing Pickering emulsion included a 3-minute homogenization time, rotation speed of 15000 rpm, and 5 % ternary composite particle addition. Under these conditions, O/W Pickering emulsion was successfully prepared, achieving a 90.5 % encapsulation rate for nuciferine. The resulting emulsion exhibited a minimum particle size of 4.09 mu m, displayed good storage stability, resistance to salt ions and pH variations, viscous fluid characteristics, tolerance to oral and gastric environments, and slow release of nuciferine in the small intestine, thereby enhancing its bioavailability. These findings offer insights into the loading and delivery of nuciferine and serve as a technical guide for developing highly stable emulsion gel systems.
Keyword ：
Emulsion stability Emulsion stability Nuciferine Nuciferine Pickering emulsion Pickering emulsion Potato short amylose Potato short amylose
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| GB/T 7714 | Li, Hua , Bai, Xue , Zeng, Jihao et al. Fabrication and characterization of potato short amylose, zein, and pectin ternary composite particles stabilized pickering emulsions and their application on nuciferine delivery [J]. | FOOD RESEARCH INTERNATIONAL , 2024 , 197 . |
| MLA | Li, Hua et al. "Fabrication and characterization of potato short amylose, zein, and pectin ternary composite particles stabilized pickering emulsions and their application on nuciferine delivery" . | FOOD RESEARCH INTERNATIONAL 197 (2024) . |
| APA | Li, Hua , Bai, Xue , Zeng, Jihao , Zhang, Jiaying , Liu, Xiaodan , Wang, Shaoyun et al. Fabrication and characterization of potato short amylose, zein, and pectin ternary composite particles stabilized pickering emulsions and their application on nuciferine delivery . | FOOD RESEARCH INTERNATIONAL , 2024 , 197 . |
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