Query：
学者姓名：陈志鑫
Refining：
Year
Type
Indexed by
Source
Complex
Former Name
Co-
Language
Clean All
Abstract ：
Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because of its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) is characterized by significant fibrous tissue growth, and high interstitial pressure hinders drug penetration into tumors. Additionally, hypoxia and immune suppression within the tumor contribute to poor responses to radiotherapy and chemotherapy, ultimately leading to an unfavorable prognosis. In this study, aPD-L1-modified docetaxel and perfluoropentane-loaded liquid-vapor phase-transformation lipid nanoparticles (aPDL1-DTX/PFP@Lipid) were synthesized and had an average diameter of 61.63 nm with 84.3% antibody modification. We demonstrated that the nanoparticles (NPs) exhibited excellent PDAC-targeting capabilities both in vitro and in vivo. Upon exposure to low-intensity pulsed ultrasound (LIPUS) stimulation, the NPs underwent a phase transformation to form microbubbles with substantial molecular ultrasound diagnostic effects, and combined treatment resulted in a tumor growth inhibition rate of 88.91%. This treatment strategy also led to the infiltration of CD8+ T cells, the downregulation of Treg cells, the promotion of M1 macrophage polarization, the inhibition of fibrosis to reduce tumor stromal pressure, and the facilitation of perfluoropentane (PFP) gasification to release O2 and improve tumor hypoxia. In conclusion, aPD-L1-modified liquid-vapor phase-transformation nanoparticles loaded with docetaxel (DTX) and PFP were successfully combined with ultrasound for the molecular diagnosis and targeted treatment of PDAC. aPDL1-DTX/PFP@Lipid could reshape the PDAC TME, offering a new approach for ultrasound-mediated diagnosis and treatment with promising clinical applications.
Keyword ：
Contrast-enhanced ultrasound Contrast-enhanced ultrasound Molecular diagnosis Molecular diagnosis Pancreatic cancer Pancreatic cancer Targeted therapy Targeted therapy Tumor microenvironment Tumor microenvironment
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Tang, Yi , Shen, Qingling , Lin, Peng et al. aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound [J]. | JOURNAL OF NANOBIOTECHNOLOGY , 2025 , 23 (1) . |
| MLA | Tang, Yi et al. "aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound" . | JOURNAL OF NANOBIOTECHNOLOGY 23 . 1 (2025) . |
| APA | Tang, Yi , Shen, Qingling , Lin, Peng , Chen, Zhixin , Fan, Denghui , Zhuo, Minling et al. aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound . | JOURNAL OF NANOBIOTECHNOLOGY , 2025 , 23 (1) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Atomically precise metal nanoclusters (NCs), distinguished by their unique electronic structures, quantum confinement effects, and enriched active sites, have been considered highly promising photosensitizers for light harvesting and conversion. However, the ultra-short carrier lifetime and poor stability of metal NCs remarkably retard their widespread applications in photocatalysis. In this study, we achieved the modulation of carrier separation over metal NCs via heterostructure engineering by smartly integrating atomically precise silver NCs [Ag16(GSH)9] with transition metal chalcogenides (TMCs). The favorable energy level alignment between metal NCs and TMCs facilitates the electron transfer from the metal NCs to the TMCs, leading to a significantly prolonged charge lifetime and considerably enhanced photoactivity toward the selective reduction of nitro compounds to amino derivatives under visible light. The photocatalytic mechanism of these composite photosystems is elucidated herein. This work advances our fundamental understanding of charge transfer mechanisms over atomically precise metal NCs for solar energy conversion. © 2024 The Royal Society of Chemistry.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Zhang, J. , Zhan, L. , Ning, B. et al. Photoredox catalysis enabled by atomically precise metal nanoclusters [J]. | Inorganic Chemistry Frontiers , 2024 , 11 (20) : 6970-6980 . |
| MLA | Zhang, J. et al. "Photoredox catalysis enabled by atomically precise metal nanoclusters" . | Inorganic Chemistry Frontiers 11 . 20 (2024) : 6970-6980 . |
| APA | Zhang, J. , Zhan, L. , Ning, B. , He, Y. , Xiao, G. , Chen, Z. et al. Photoredox catalysis enabled by atomically precise metal nanoclusters . | Inorganic Chemistry Frontiers , 2024 , 11 (20) , 6970-6980 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Atomically precise metal nanoclusters (NCs) for use as photosensitizers in photocatalysis have attracted considerable attention due to their quantum confinement effect, unique atom-stacking fashion, and enriched catalytic active sites, which make them promising photosensitizers for solar energy conversion. However, current works on metal NC-based photocatalytic systems are still in their infancy owing to the complex synthetic strategies of metal NCs and deficiency of metal NCs with a favorable energy level configuration, which substantially limit the exploration of metal NC photocatalytic systems, while the photocatalytic mechanism remains elusive. Herein, we conceptually demonstrate the construction of a metal NC/transition metal chalcogenide (TMC) binary heterostructure photosystem via electrostatic self-assembly under ambient conditions, wherein Ag-25(SR)(18) NCs (SR: 2,4-dimethylbenzenethiol) were precisely and uniformly anchored on the surface of TMCs to function as light-harvesting antenna. We ascertained that advantageous charge transfer between the TMCs and Ag-25(SR)(18) NCs resulted in a prolonged charge lifetime and increased carrier density. Therefore, self-assembled metal NCs/TMCs heterostructures demonstrated significantly improved and versatile photoactivities toward the anaerobic photoreduction of aromatic nitro compounds to amino derivatives and heavy metal ion (Cr6+) reduction under visible light. Our work clarifies the photocatalytic mechanism of atomically precise metal NC photocatalysis and opens up new avenues for smartly mediating the charge transfer and separation of metal NCs for solar energy conversion.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Zhan, Linjian , Zhang, Junyi , Ning, Boyuan et al. Atomically precise Ag25(SR)18 nanoclusters: a stable photosensitizer for photocatalysis [J]. | INORGANIC CHEMISTRY FRONTIERS , 2024 , 11 (22) : 7991-8002 . |
| MLA | Zhan, Linjian et al. "Atomically precise Ag25(SR)18 nanoclusters: a stable photosensitizer for photocatalysis" . | INORGANIC CHEMISTRY FRONTIERS 11 . 22 (2024) : 7991-8002 . |
| APA | Zhan, Linjian , Zhang, Junyi , Ning, Boyuan , He, Yunhui , Xiao, Guangcan , Chen, Zhixin et al. Atomically precise Ag25(SR)18 nanoclusters: a stable photosensitizer for photocatalysis . | INORGANIC CHEMISTRY FRONTIERS , 2024 , 11 (22) , 7991-8002 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Background: Energy shortages and environmental pollution are two of the most immediate problems all over the world. Photocatalysis is expanding into energy and environmental applications. Methods: In this study, novel visible-light-driven Ag2WO4/AgVO3 composite photocatalysts were constructed via a one-pot, controllable, ligand-free and eco-friendly approach and analyzed using different techniques. Under visible light irradiation, photocatalytic behavior of type-II heterojunctions in the degradation of levofloxacin hydrochloride is investigated. Significant findings: Various characterizations showed that Ag2WO4 was successfully loaded onto the AgVO3 surface, which improved the separation and transfer efficiency of the photogenerated charge carriers. Under optimal experimental conditions, the removal efficiency of levofloxacin reached 0.0194 min-1 for the Ag2WO4/ AgVO3 composites with a 3 : 5 mass ratio (3-WV), which was 5.87 and 17.64 times that of pure AgVO3 and Ag2WO4, respectively. The photocatalytic mechanism of typical type-II heterojunction was discussed. Furthermore, possible photodegradation pathway of levofloxacin was comprehensively determined by LC-MS analysis. This work will provide new motivation for the design and synthesis of simple preparation and highly efficient photocatalysts for environmental purification.
Keyword ：
Ag-based photocatalyst Ag-based photocatalyst Degradation Degradation Pathway Pathway Photocatalytic reduction Photocatalytic reduction
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen, Zhixin . One-pot, room-temperature synthesis of novel Ag2WO4/AgVO3 composites with high photocatalytic activities under visible light irradiation [J]. | JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS , 2024 , 156 . |
| MLA | Chen, Zhixin . "One-pot, room-temperature synthesis of novel Ag2WO4/AgVO3 composites with high photocatalytic activities under visible light irradiation" . | JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS 156 (2024) . |
| APA | Chen, Zhixin . One-pot, room-temperature synthesis of novel Ag2WO4/AgVO3 composites with high photocatalytic activities under visible light irradiation . | JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS , 2024 , 156 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Wastewater pollutants are a major threat to natural resources, with antibiotics and heavy metals being common water contaminants. By harnessing clean, renewable solar energy, photocatalysis facilitates the synergistic removal of heavy metals and antibiotics. In this paper, MXene was both a template and raw material, and MXene-derived oxide (TiO2) and SnIn4S8 Z-scheme composite materials were synthesized and characterized. The synergistic mode of photocatalytic reduction and oxidation leads to the enhanced utilization of e(-)/h(+) pairs. The TiO2/SnIn4S8 exhibited a higher photocatalytic capacity for the simultaneous removal of tetracycline (TC) (20 mg center dot L-1) and Cr(VI) (15 mg center dot L-1). The main active substances of TC degradation and Cr(VI) reduction were identified via free radical scavengers and electron paramagnetic resonance (EPR). Additionally, the potential photocatalytic degradation route of TC was thoroughly elucidated through liquid chromatography-mass spectrometry (LC-MS).
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Ning, Boyuan , Chen, Zhixin , Cai, Yanqing et al. Simultaneous Photocatalytic Tetracycline Oxidation and Cr(VI) Reduction by Z-Scheme Multiple Layer TiO2/SnIn4S8 [J]. | LANGMUIR , 2024 , 40 (17) : 9144-9154 . |
| MLA | Ning, Boyuan et al. "Simultaneous Photocatalytic Tetracycline Oxidation and Cr(VI) Reduction by Z-Scheme Multiple Layer TiO2/SnIn4S8" . | LANGMUIR 40 . 17 (2024) : 9144-9154 . |
| APA | Ning, Boyuan , Chen, Zhixin , Cai, Yanqing , Xiao, Fang-Xing , Xu, Pingfan , Xiao, Guangcan et al. Simultaneous Photocatalytic Tetracycline Oxidation and Cr(VI) Reduction by Z-Scheme Multiple Layer TiO2/SnIn4S8 . | LANGMUIR , 2024 , 40 (17) , 9144-9154 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Atomically precise metal nanoclusters (NCs), distinguished by their unique electronic structures, quantum confinement effects, and enriched active sites, have been considered highly promising photosensitizers for light harvesting and conversion. However, the ultra-short carrier lifetime and poor stability of metal NCs remarkably retard their widespread applications in photocatalysis. In this study, we achieved the modulation of carrier separation over metal NCs via heterostructure engineering by smartly integrating atomically precise silver NCs [Ag16(GSH)9] with transition metal chalcogenides (TMCs). The favorable energy level alignment between metal NCs and TMCs facilitates the electron transfer from the metal NCs to the TMCs, leading to a significantly prolonged charge lifetime and considerably enhanced photoactivity toward the selective reduction of nitro compounds to amino derivatives under visible light. The photocatalytic mechanism of these composite photosystems is elucidated herein. This work advances our fundamental understanding of charge transfer mechanisms over atomically precise metal NCs for solar energy conversion. The heterostructure is elaborately designed by a self-assembly strategy, wherein Ag16(GSH)9 nanoclusters serve as photosensitizers to participate in interfacial charge transfer, ultimately resulting in significantly enhanced photoredox catalysis.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Zhang, Junyi , Zhan, Linjian , Ning, Boyuan et al. Photoredox catalysis enabled by atomically precise metal nanoclusters [J]. | INORGANIC CHEMISTRY FRONTIERS , 2024 , 11 (20) : 6970-6980 . |
| MLA | Zhang, Junyi et al. "Photoredox catalysis enabled by atomically precise metal nanoclusters" . | INORGANIC CHEMISTRY FRONTIERS 11 . 20 (2024) : 6970-6980 . |
| APA | Zhang, Junyi , Zhan, Linjian , Ning, Boyuan , He, Yunhui , Xiao, Guangcan , Chen, Zhixin et al. Photoredox catalysis enabled by atomically precise metal nanoclusters . | INORGANIC CHEMISTRY FRONTIERS , 2024 , 11 (20) , 6970-6980 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Background: The role of thioredoxin-interacting protein (TXNIP) in lipopolysaccharide-induced liver injury in mice has been reported, but the underlying mechanisms are poorly understood. Methods: We overexpressed deubiquitinase in cells overexpressing TXNIP and then detected the level of TXNIP to screen out the deubiquitinase regulating TXNIP; the interaction between TXNIP and deubiquitinase was verified by coimmunoprecipitation. After knockdown of a deubiquitinase and overexpression of TXNIP in Huh7 and HepG2 cells, lipopolysaccharide was used to establish a cellular inflammatory model to explore the role of deubiquitinase and TXNIP in hepatocyte inflammation. Results: In this study, we discovered that ubiquitin-specific protease 5 (USP5) interacts with TXNIP and stabilizes it through deubiquitylation in Huh-7 and HepG2 cells after treatment with lipopolysaccharide. In lipopolysaccharide-treated Huh-7 and HepG2 cells, USP5 knockdown increased cell viability, reduced apoptosis, and decreased the expression of inflammatory factors, including NLRP3, IL-1 beta, IL-18, ASC, and procaspase-1. Overexpression of TXNIP reversed the phenotype induced by knockdown USP5. Conclusions: In summary, USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Shi, Songchang , Pan, Xiaobin , Chen, Minyong et al. USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein [J]. | HEPATOLOGY COMMUNICATIONS , 2023 , 7 (8) . |
| MLA | Shi, Songchang et al. "USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein" . | HEPATOLOGY COMMUNICATIONS 7 . 8 (2023) . |
| APA | Shi, Songchang , Pan, Xiaobin , Chen, Minyong , Zhang, Lihui , Zhang, Shujuan , Wang, Xincai et al. USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein . | HEPATOLOGY COMMUNICATIONS , 2023 , 7 (8) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Background: The accumulation of antibiotics in water systems has received considerable global attention due to its detrimental effects. There is an urgent need to develop rapid and efficient methods for the degradation of antibiotics.Methods: In this work, a highly efficient AgFeO2/Ag3VO4 photocatalyst was successfully fabricated by a hydrothermal method and analyzed using different techniques. Under visible light irradiation, photocatalytic behavior of AgFeO2/Ag3VO4 heterojunctions in the degradation of levofloxacin is investigated. Significant findings: The results showed that p-n heterojunction was formed between AgFeO2 and Ag3VO4, which improved the separation and transfer of photogenerated charge carrier under the action of the internal electric field. The apparent reaction rate of AgFeO2/Ag3VO4 heterostructure toward degradation of levofloxacin reached to 0.2770 min-1, which was about 2.15 times and 36.73 times larger than those of Ag3VO4 and AgFeO2, respectively, and much larger than other counterparts. Furthermore, possible photocatalytic degradation pathway of levofloxacin was comprehensively determined by LC-MS analysis. This work would provide in-depth understanding on the efficient photocatalytic removal of antibiotics for sustainable environmental remediation.
Keyword ：
Degradation pathway Degradation pathway p-n heterojunction p-n heterojunction Visible-light photocatalysis Visible-light photocatalysis
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen, Zhixin , Ning, Boyuan , Cai, Yanqing et al. Rapid degradation of levofloxacin by p-n heterojunction AgFeO2/Ag3VO4 photocatalyst: Mechanism study and degradation pathway [J]. | JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS , 2023 , 151 . |
| MLA | Chen, Zhixin et al. "Rapid degradation of levofloxacin by p-n heterojunction AgFeO2/Ag3VO4 photocatalyst: Mechanism study and degradation pathway" . | JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS 151 (2023) . |
| APA | Chen, Zhixin , Ning, Boyuan , Cai, Yanqing , Liu, Minghua , Xu, Pingfan , Zhang, Peikun et al. Rapid degradation of levofloxacin by p-n heterojunction AgFeO2/Ag3VO4 photocatalyst: Mechanism study and degradation pathway . | JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS , 2023 , 151 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Background and Objectives: Targeted drug is often engulfed and cleared by the reticuloendothelial system in vivo, resulting in reduced treatment efficacy. This study aimed to explore the biodistribution and HER-2-targeted antitumor effects of trastuzumab-modified gold nanorods (Tra-AuNRs) in a gastric cancer animal model. Methods: Gold nanorods were synthesized using a seed-mediated growth method, and then subjected to trastuzumab-targeted modification. Elemental analysis, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy were performed; UV-visible absorption peak, photothermal effects, morphology, and size distribution of Tra-AuNRs were characterized. The targeted killing effect of Tra-AuNRs on gastric cancer cells was assessed in vitro. Tra-AuNRs were injected intravenously and intratumorally into gastric cancer-bearing nude mice in vivo and their distribution was detected. Tumor growth inhibition rate and tumor apoptosis-related protein expression were compared between groups. Results: Tra-AuNRs presented a relatively uniform morphology with an average particle size of 59.9 nm and a longitudinal plasmon resonance absorption peak of 790 nm. The targeted killing rate of gastric cancer cells in vitro by Tra-AuNRs was 87.9%. After intravenous injection, Tra-AuNRs were mainly distributed in the liver, tumor, spleen, and lungs. Comparatively, Tra-AuNRs were mainly distributed in the tumor when intratumorally injected, with a tumor concentration of 6.42 mu g/g after 24 h. The tumor growth inhibition rate reached 78.3% in the intratumoral injection group, with significantly higher BAX, BAD, and CASPASE-3 expression than that in the intravenous injection group. Conclusion: The findings suggest that Tra-AuNRs can be used for HER-2-positive gastric cancer treatment. Intratumoral injection of Tra-AuNRs significantly increased the local tumor drug concentration and improved the molecular targeted antitumor growth effect in gastric cancer-bearing nude mice.
Keyword ：
biodistribution biodistribution gastric cancer gastric cancer gold nanorod gold nanorod HER-2 HER-2 Targeted therapy Targeted therapy trastuzumab trastuzumab
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Tang Yi , Cai Hongjiao , Zhuo Minling et al. Biodistribution and Targeted Antitumor Effects of Trastuzumab-Modified Gold Nanorods in Mice with Gastric Cancer [J]. | CURRENT DRUG DELIVERY , 2023 , 21 (3) : 421-430 . |
| MLA | Tang Yi et al. "Biodistribution and Targeted Antitumor Effects of Trastuzumab-Modified Gold Nanorods in Mice with Gastric Cancer" . | CURRENT DRUG DELIVERY 21 . 3 (2023) : 421-430 . |
| APA | Tang Yi , Cai Hongjiao , Zhuo Minling , Yang Xin , Qian Qingfu , Chen Zhixin et al. Biodistribution and Targeted Antitumor Effects of Trastuzumab-Modified Gold Nanorods in Mice with Gastric Cancer . | CURRENT DRUG DELIVERY , 2023 , 21 (3) , 421-430 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
本发明提供一种钨酸银/偏钒酸银复合光催化剂的制备及其应用。该复合光催化剂由钨酸银纳米颗粒复合在一维棒状的偏钒酸银上组成，在制备过程采用一步沉淀法合成钨酸银/偏钒酸银复合光催化剂。与单独的钨酸银和偏钒酸银相比，钨酸银/偏钒酸银复合光催化活性得到明显提高。钨酸银/偏钒酸银复合光催化剂具有制备方法简单、条件易控、能耗低和光催化活性好等优点，是一种新型光催化剂并成功应用于染料降解。
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 陈志鑫 , 蔡燕卿 , 刘明华 et al. 一种钨酸银/偏钒酸银复合光催化剂的制备及其应用 : CN202111620135.4[P]. | 2021-12-28 00:00:00 . |
| MLA | 陈志鑫 et al. "一种钨酸银/偏钒酸银复合光催化剂的制备及其应用" : CN202111620135.4. | 2021-12-28 00:00:00 . |
| APA | 陈志鑫 , 蔡燕卿 , 刘明华 , 肖光参 , 何运慧 . 一种钨酸银/偏钒酸银复合光催化剂的制备及其应用 : CN202111620135.4. | 2021-12-28 00:00:00 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
