Query:
学者姓名:郑允权
Refining:
Year
Type
Indexed by
Source
Complex
Former Name
Co-
Language
Clean All
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Yang, Jianmin , Cai, Fengying , Lv, Yicheng et al. Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds (vol 257, 128561, 2024) [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 297 . |
MLA | Yang, Jianmin et al. "Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds (vol 257, 128561, 2024)" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 297 (2025) . |
APA | Yang, Jianmin , Cai, Fengying , Lv, Yicheng , Jiang, Ting , Zhao, Xingkai , Hu, Xueli et al. Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds (vol 257, 128561, 2024) . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 297 . |
Export to | NoteExpress RIS BibTex |
Version :
Abstract :
The inadequate vascularization and abnormal immune microenvironment in the diabetic bone defect region present a significant challenge to osteogenic regulation. Inspired by the distinctive characteristics of healing staged in diabetic bone defects and the structure-function relationship in the natural periosteum, we fabricated an electrospun bilayer biomimetic periosteum (Bilayer@E) to promote regeneration of diabetic bone defects. Here, the inner layer of biomimetic periosteum was fabricated using coaxial electrospinning fibers, with a shell incorporating zinc oxide nanoparticles (ZnO NPs) and a core containing silicon dioxide nanoparticles (SiO2 NPs) mimicking the cambium of periosteum; the outer layer consisted of randomly aligned electrospun fibers loaded with deferoxamine (DFO), simulating the fibrous layer of periosteum; finally, epigallocatechin-3-gallate (EGCG) was coated onto the bilayer membrane to obtain Bilayer@E. The presence of EGCG on the Bilayer@E surface efficiently triggers a phenotypic transition in macrophages, shifting them from an M1 proinflammatory state to an M2 anti-inflammatory state. Moreover, the sequential release of ZnO NPs, DFO, and SiO2 NPs exhibits antimicrobial characteristics while coordinating angiogenesis and promoting osteogenic mineralization in cells. Importantly, the biomimetic periosteum shows strong in vivo bone tissue and periosteal regeneration properties in diabetic rats. The integration of sequential drug release and immunomodulation, tailored to meet the specific healing requirements during bone regeneration, offers new insights for advancing the application of biomaterials in this field.
Keyword :
biomimetic periosteum biomimetic periosteum bone regeneration bone regeneration diabetesmellitus diabetesmellitus electrospinning electrospinning immunomodulation immunomodulation
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Zhuang, Yu , Wu, Dingwei , Zhou, Lvyang et al. Electrospun Biomimetic Periosteum Promotes Diabetic Bone Defect Regeneration through Regulating Macrophage Polarization and Sequential Drug Release [J]. | ACS BIOMATERIALS SCIENCE & ENGINEERING , 2025 , 11 (3) : 1690-1704 . |
MLA | Zhuang, Yu et al. "Electrospun Biomimetic Periosteum Promotes Diabetic Bone Defect Regeneration through Regulating Macrophage Polarization and Sequential Drug Release" . | ACS BIOMATERIALS SCIENCE & ENGINEERING 11 . 3 (2025) : 1690-1704 . |
APA | Zhuang, Yu , Wu, Dingwei , Zhou, Lvyang , Liu, Boyuan , Zhao, Xingkai , Yang, Jianmin et al. Electrospun Biomimetic Periosteum Promotes Diabetic Bone Defect Regeneration through Regulating Macrophage Polarization and Sequential Drug Release . | ACS BIOMATERIALS SCIENCE & ENGINEERING , 2025 , 11 (3) , 1690-1704 . |
Export to | NoteExpress RIS BibTex |
Version :
Abstract :
In anterior cruciate ligament (ACL) repair methods, the continuous enzymatic erosion of synovial fluid can impede healing and potentially lead to repair failure, as well as exacerbate articular cartilage wear, resulting in joint degeneration. Inspired by the blood clot during medial collateral ligament healing, we developed a composite scaffold comprising collagen (1 %, w/v) and polyvinyl alcohol (5 %, w/v) combined with platelet-rich plasma (PRP). The composite scaffold provides a protective barrier against synovial erosion for the ruptured ACL, while simultaneously facilitating tissue repair, thereby enhancing the efficacy of ACL repair techniques. The composite scaffold is primarily formed through hydrogen bonding between molecular chains and physical cross- linking of microcrystalline regions using a simple cyclic freeze-thaw method, resulting in improved mechanical properties and an extended degradation period. The maximum tensile fracture load of the composite scaffold reached 5.99 +/- 0.30 N. The incorporation of PRP facilitates cell migration, proliferation, and blood vessel growth by enabling slow release of various growth factors. In vivo results demonstrate that this composite scaffold promotes rabbit hindlimb rupture ACL healing by stimulating fibroblast proliferation, collagen deposition, microvascular formation, and proprioceptor generation. Furthermore, it effectively reduces meniscus and cartilage wear while mitigating bone arthritis and joint degenerative diseases. Overall, our proposed composite scaffold holds great promise as a candidate for ACL healing.
Keyword :
Anterior cruciate ligament Anterior cruciate ligament Biodegradable scaffold Biodegradable scaffold Collagen Collagen Platelet-rich plasma Platelet-rich plasma Polyvinyl alcohol Polyvinyl alcohol
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Sun, Xiaohan , Zhang, Nanxin , Chen, Longhui et al. Collagen/polyvinyl alcohol scaffolds combined with platelet-rich plasma to enhance anterior cruciate ligament repair [J]. | BIOMATERIALS ADVANCES , 2025 , 169 . |
MLA | Sun, Xiaohan et al. "Collagen/polyvinyl alcohol scaffolds combined with platelet-rich plasma to enhance anterior cruciate ligament repair" . | BIOMATERIALS ADVANCES 169 (2025) . |
APA | Sun, Xiaohan , Zhang, Nanxin , Chen, Longhui , Lai, Yuchao , Yang, Shasha , Li, Qiang et al. Collagen/polyvinyl alcohol scaffolds combined with platelet-rich plasma to enhance anterior cruciate ligament repair . | BIOMATERIALS ADVANCES , 2025 , 169 . |
Export to | NoteExpress RIS BibTex |
Version :
Abstract :
The redox homeostasis defense mechanism of tumor cells is one of the prime reasons for the unsatisfactory effect of photodynamic therapy (PDT). So far, little attention has been paid to this obstacle. In this work, we reported a synthesizing simple yet versatile nanogel (BCPS), synthesized by cystamine dihydrochloride functionalized sodium carboxymethylcellulose (CMC-SS), bovine serum albumin, and Phycocyanobilin self-assembly. The BCPS reduced the levels of glutathione molecules by reacting with glutathione, thereby interfering with intracellular redox homeostasis and enhancing the sensitivity of tumor cells to PDT. The BCPS was shown to possess excellent serum stability, high blood compatibility, low toxic side effects, and higher reactive oxygen species (ROS) utilization. After irradiation, the BCPS could significantly increase intracellular ROS level by approximately 1.6-fold and decrease the IC50 to HeLa cells by approximately 1.5-fold, compared to the pre-functional drugs BCP. This proposed strategy, based on increasing the utilization rate of ROS in tumor cells is promising for application potentials in tumor therapy.
Keyword :
Green self-assembly Green self-assembly Long-circulating Long-circulating Photodynamic therapy Photodynamic therapy Redox-responsive Redox-responsive Tumor-targeted drug delivery Tumor-targeted drug delivery
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Liao, Wenqiang , Xiao, Siqi , Yang, Jianmin et al. Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy [J]. | CARBOHYDRATE POLYMERS , 2024 , 323 . |
MLA | Liao, Wenqiang et al. "Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy" . | CARBOHYDRATE POLYMERS 323 (2024) . |
APA | Liao, Wenqiang , Xiao, Siqi , Yang, Jianmin , Shi, Xianai , Zheng, Yunquan . Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy . | CARBOHYDRATE POLYMERS , 2024 , 323 . |
Export to | NoteExpress RIS BibTex |
Version :
Abstract :
Abdominal and intrauterine adhesions are common postoperative problems that can cause serious complications. Current adhesives are usually double sided and suffer from poor wet adhesion, nondegradability, and monofunctionality, which limits their application in preventing postoperative adhesions. Herein, a bioinspired microstructured Janus bioadhesive, named OD/GM@PG, with a wet adhesive inner layer and an antiadhesive outer layer is prepared by combining electrostatic spun and adhesive materials. By using both capillary suction and a catechol-based strategy, the wet adhesive strength and interfacial toughness of the Janus bioadhesive reach 98 kPa and 325 J m-2, respectively, which are much higher than those of commercial fibrin glues and cyanoacrylate glues. The electrostatic spun outer layer acts as a physical barrier with antiadhesive and friction-reducing effects. Additionally, the Janus bioadhesive demonstrates biodegradable, hemostatic, antioxidative, anti-inflammatory, and prohealing properties. In vivo results show that the asymmetric adhesion effect of the Janus bioadhesive effectively preventing postoperative abdominal and intrauterine adhesions. Notably, tandem mass tags-labeled quantitative proteomics analysis demonstrate that the expression of inflammatory response-associated proteins (S100A8, S100A9) is associated with adhesion; the Janus bioadhesive significantly downregulates this expression. Therefore, the OD/GM@PG Janus bioadhesive is a promising candidate for preventing postoperative adhesions. A bioinspired microstructured Janus bioadhesive with an asymmetric structure and adhesion behavior is prepared by combining electrostatic spinning and adhesive materials. By employing capillary suction and a catechol-based strategy, the Janus bioadhesive exhibits impressive wet adhesive strength and interfacial toughness. Furthermore, the asymmetric adhesion effect of the Janus bioadhesive effectively alleviates postoperative abdominal and intrauterine adhesions. image
Keyword :
capillary suction capillary suction fertility restoration fertility restoration Janus bioadhesive Janus bioadhesive preventing postoperative adhesion preventing postoperative adhesion wet adhesion wet adhesion
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Lv, Yicheng , Cai, Fengying , Zhao, Xingkai et al. Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (21) . |
MLA | Lv, Yicheng et al. "Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions" . | ADVANCED FUNCTIONAL MATERIALS 34 . 21 (2024) . |
APA | Lv, Yicheng , Cai, Fengying , Zhao, Xingkai , Zhu, Xintao , Wei, Fanan , Zheng, Yunquan et al. Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions . | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (21) . |
Export to | NoteExpress RIS BibTex |
Version :
Abstract :
Platelet-rich plasma (PRP) has become an important regenerative therapy. However, the preparation method of PRP has not been standardized, and the optimal platelet concentration for PRP used in skin wound repair is unclear, leading to inconsistent clinical efficacy of PRP. Therefore, the development of standardized preparation methods for PRP and the investigation of the dose-response relationship between PRP with different platelet concentrations and tissue regeneration plays an important role in the development and clinical application of PRP technology. This study has developed an integrated blood collection device from blood drawing to centrifugation. Response surface methodology was employed to optimize the preparation conditions, ultimately achieving a platelet recovery rate as high as 95.74% for PRP (with optimal parameters: centrifugation force 1730x g, centrifugation time 10 min, and serum separation gel dosage 1.4 g). Both in vitro and in vivo experimental results indicate that PRP with a (2x) enrichment ratio is the most effective in promoting fibroblast proliferation and skin wound healing, with a cell proliferation rate of over 150% and a wound healing rate of 78% on day 7.
Keyword :
high recovery rate high recovery rate optimal preparation method optimal preparation method platelet-poor plasma platelet-poor plasma platelet-rich plasma platelet-rich plasma skin restoration skin restoration
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Qiu, Mengjie , He, Yating , Zhang, Haijie et al. Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2024 , 25 (17) . |
MLA | Qiu, Mengjie et al. "Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25 . 17 (2024) . |
APA | Qiu, Mengjie , He, Yating , Zhang, Haijie , Zheng, Yunquan , Shi, Xianai , Yang, Jianmin . Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2024 , 25 (17) . |
Export to | NoteExpress RIS BibTex |
Version :
Abstract :
The management of severe full-thickness skin defect wounds remains a challenge due to their irregular shape, uncontrollable bleeding, high risk of infection, and prolonged healing period. Herein, an all-in-one OD/GM/QCS@Exo hydrogel was prepared with catechol-modified oxidized hyaluronic acid (OD), methylacrylylated gelatin (GM), and quaternized chitosan (QCS) and loaded with adipose mesenchymal stem cell-derived exosomes (Exos). Cross-linking of the hydrogel was achieved using visible light instead of ultraviolet light irradiation, providing injectability and good biocompatibility. Notably, the incorporation of catechol groups and multicross-linked networks in the hydrogels conferred strong adhesion properties and mechanical strength against external forces such as tensile and compressive stress. Furthermore, our hydrogel exhibited antibacterial, anti-inflammatory, and antioxidant properties along with wound-healing promotion effects. Our results demonstrated that the hydrogel-mediated release of Exos significantly promotes cellular proliferation, migration, and angiogenesis, thereby accelerating skin structure reconstruction and functional recovery during the wound-healing process. Overall, the all-in-one OD/GM/QCS@Exo hydrogel provided a promising therapeutic strategy for the treatment of full-thickness skin defect wounds through actively participating in the entire process of wound healing.
Keyword :
all-in-one all-in-one exosomes exosomes multifunctionalhydrogel multifunctionalhydrogel quaternized chitosan quaternized chitosan visible light cross-linkable visible light cross-linkable
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Lv, Yicheng , Li, Liang , Zhang, Jingyuan et al. Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (20) : 25923-25937 . |
MLA | Lv, Yicheng et al. "Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process" . | ACS APPLIED MATERIALS & INTERFACES 16 . 20 (2024) : 25923-25937 . |
APA | Lv, Yicheng , Li, Liang , Zhang, Jingyuan , Li, Jingsi , Cai, Fengying , Huang, Yufeng et al. Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (20) , 25923-25937 . |
Export to | NoteExpress RIS BibTex |
Version :
Abstract :
Sleep duration is one of the eight factors of health in life. High incidence of insomnia and other sleep disorders cause insufficient sleep. Chronic mild sleep deprivation leads to endothelial oxidative stress and impaired antioxidant response, which increases the risk of cardiovascular and cancer diseases over time. The lotus is a valuable agricultural commodity highly prized for its diverse edible and medicinal parts. lotus leaves as a part of the lotus, which contain the abundant bioactive substance Nuciferine (Nuc). Herein we found that Nuciferine significantly decreased spontaneous activity and sleep latency in mice, while markedly increasing sleep duration. Additionally, it has a sleep-enhancing effect by raising levels of gamma-aminobutyric acid (GABA) and lowering Glutamate (Glu), Dopamine (DA), and Norepinephrine (NE) in mouse plasma. This sleep-enhancing effect is impeded by Picrotoxin (Pic) and intensified by 5-hydroxytryptophan (5-HTP). The results indicate that Nuciferine may induce its sleep-enhancing effect through the GABAergic and monoaminergic nervous systems. Furthermore, this study constructed an insomnia model and revealed that Nuciferine could regulate inflammatory factors (including IL-1 beta and TNF-alpha) in plasma and brain tissue, resulting in successful treatment of insomnia in vivo. The c-fos immunofluorescence, Nissl staining and H&E staining illustrated a reversal of low neuronal activity in insomniac mice, demonstrating a protective effect on brain tissue structure. These findings suggest that Nuciferine, which is present in lotus leaves, may improve sleep quality by utilizing multiple pathways, decreasing low neuronal activity associated with insomnia, and reversing abnormalities in brain tissue.
Keyword :
Lotus leaves Lotus leaves Neuroprotective Neuroprotective Neurotransmitter Neurotransmitter Nuciferine Nuciferine Sleep-enhancing effect Sleep-enhancing effect
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Zhang, Haijie , Wu, Yinbo , Qiu, Mengjie et al. Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia [J]. | FOOD BIOSCIENCE , 2024 , 62 . |
MLA | Zhang, Haijie et al. "Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia" . | FOOD BIOSCIENCE 62 (2024) . |
APA | Zhang, Haijie , Wu, Yinbo , Qiu, Mengjie , Zheng, Yunquan , Chen, Li , Shi, Xianai et al. Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia . | FOOD BIOSCIENCE , 2024 , 62 . |
Export to | NoteExpress RIS BibTex |
Version :
Abstract :
The healing process of diabetic foot ulcers is challenging due to the presence of a complex and severe inflammatory microenvironment, characterized by hyperglycemia, low pH, susceptibility to infection, vascular dysfunction, and over-expression of reactive oxygen species (ROS), which can potentially lead to amputation or even mortality. Herein, a glucose and pH dual-responsive hydrogel was designed and prepared by crosslinking phenylboronic acid-grafted quaternary chitosan (QF, 4 wt%) with dopamine-grafted oxidized hyaluronic acid (OD, 5 wt%) through phenylboronation, schiff-base reaction, and other techniques. The multifunctional QO/ @PV@AB7 hydrogel was prepared by incorporating pravastatin-loaded chitosan nanoparticles (CSNPs@PV, 2 mg/mL) and antimicrobial peptide AMP-AB7 loaded silica nanoparticles (SiO2NPs@AB7, 0.5 mg/mL). The results demonstrate that the QO/@PV@AB7 hydrogel exhibits good responsiveness to acidic conditions and high glucose levels, while effectively scavenging various types of ROS. Moreover, it exerted protective effects against oxidative stress on cells, enhanced HUVECs viability, and promoted angiogenesis. Notably, the QO/@PV@AB7 hydrogel displayed potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Additionally, in an MRSA-infected rat model of diabetic foot wounds, administration of the QO/ @PV@AB7 hydrogel led to increased secretion of pro-angiogenic factors such as vascular endothelial nitric oxide synthase (eNOS), vascular endothelial-generating factor (VEGF), and endothelial cell adhesion molecule (CD31). Furthermore, the hydrogel significantly reduced the levels of inflammatory factors such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), while simultaneously increasing the levels of anti-inflammatory cytokines such as interleukin-10 (IL-10). The findings suggest that multifunctional hydrogels incorporating PV@CSNPs and SiO2NPs@AB7 demonstrate promising potential as a therapeutic approach for the treatment of diabetic foot. Statement of Significance: Here, a glucose and pH dual-responsive QO/@PV@AB7 hydrogel with antimicrobial and angiogenesis-promoting properties was developed for the treatment of infected wounds in diabetic feet. Our findings demonstrate that the proposed hydrogel exhibits good responsiveness, effectively scavenges various types of reactive oxygen species (DPPH, O2-,-OH, and ABTS+), provides protection against oxidative stress, enhances HUVECs cell viability, and promotes angiogenesis. Notably, it also demonstrates potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and E. coli. Additionally, in vivo experiments demonstrated that the hydrogel exhibited accelerated wound healing in MRSA-infected diabetic foot ulcers, with a reduction of four days compared to the control group.
Keyword :
Antimicrobial peptide Antimicrobial peptide Antioxidant Antioxidant Diabetic foot Diabetic foot Pro-angiogenesis Pro-angiogenesis Responsive hydrogel Responsive hydrogel
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Li, Zhendong , Chen, Longhui , Yang, Shasha et al. Glucose and pH dual-responsive hydrogels with antibacterial, reactive oxygen species scavenging, and angiogenesis properties for promoting the healing of infected diabetic foot ulcers [J]. | ACTA BIOMATERIALIA , 2024 , 190 : 205-218 . |
MLA | Li, Zhendong et al. "Glucose and pH dual-responsive hydrogels with antibacterial, reactive oxygen species scavenging, and angiogenesis properties for promoting the healing of infected diabetic foot ulcers" . | ACTA BIOMATERIALIA 190 (2024) : 205-218 . |
APA | Li, Zhendong , Chen, Longhui , Yang, Shasha , Han, Jinzhi , Zheng, Yunquan , Chen, Zelong et al. Glucose and pH dual-responsive hydrogels with antibacterial, reactive oxygen species scavenging, and angiogenesis properties for promoting the healing of infected diabetic foot ulcers . | ACTA BIOMATERIALIA , 2024 , 190 , 205-218 . |
Export to | NoteExpress RIS BibTex |
Version :
Abstract :
The effective repair of large bone defects remains a major challenge due to its limited self-healing capacity. Inspired by the structure and function of the natural periosteum, an electrospun biomimetic periosteum is constructed to programmatically promote bone regeneration using natural bone healing mechanisms. The biomimetic periosteum is composed of a bilayer with an asymmetric structure in which an aligned electrospun poly(epsilon-caprolactone)/gelatin/deferoxamine (PCL/GEL/DFO) layer mimics the outer fibrous layer of the periosteum, while a random coaxial electrospun PCL/GEL/aspirin (ASP) shell and PCL/silicon nanoparticles (SiNPs) core layer mimics the inner cambial layer. The bilayer controls the release of ASP, DFO, and SiNPs to precisely regulate the inflammatory, angiogenic, and osteogenic phases of bone repair. The random coaxial inner layer can effectively antioxidize, promoting cell recruitment, proliferation, differentiation, and mineralization, while the aligned outer layer can promote angiogenesis and prevent fibroblast infiltration. In particular, different stages of bone repair are modulated in a rat skull defect model to achieve faster and better bone regeneration. The proposed biomimetic periosteum is expected to be a promising candidate for bone defect healing. An electrospun biomimetic periosteum with an asymmetric structure is prepared through aligned and coaxial electrospinning for programed promotion of bone regeneration. This biomimetic periosteum exhibits controlled release of multiple agents, enabling regulation of the inflammatory, angiogenic, and osteogenic phases that are essential for bone healing. It demonstrates good efficacy in promoting bone regeneration in a rat skull defect model. image
Keyword :
asymmetric structure asymmetric structure biomimetic periosteum biomimetic periosteum bone defect bone defect electrospinning electrospinning programmed repair programmed repair
Cite:
Copy from the list or Export to your reference management。
GB/T 7714 | Zhao, Xingkai , Zhuang, Yu , Cao, Yongjian et al. Electrospun Biomimetic Periosteum Capable of Controlled Release of Multiple Agents for Programmed Promoting Bone Regeneration [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (12) . |
MLA | Zhao, Xingkai et al. "Electrospun Biomimetic Periosteum Capable of Controlled Release of Multiple Agents for Programmed Promoting Bone Regeneration" . | ADVANCED HEALTHCARE MATERIALS 13 . 12 (2024) . |
APA | Zhao, Xingkai , Zhuang, Yu , Cao, Yongjian , Cai, Fengying , Lv, Yicheng , Zheng, Yunquan et al. Electrospun Biomimetic Periosteum Capable of Controlled Release of Multiple Agents for Programmed Promoting Bone Regeneration . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (12) . |
Export to | NoteExpress RIS BibTex |
Version :
Export
Results: |
Selected to |
Format: |