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学者姓名：肖高
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本发明公开了一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料电催化剂材料及其制备方法，所述纳米材料活性物质为Ce‑MOF@BT‑Cu。燃料电池催化剂目前普遍面临着，前驱体单一和合成成本高昂的问题，而商业铂碳催化剂不仅成本高且稳定性差。为克服这些问题，本发明基于金属多酚网络的独特结构，开发了一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料。该材料呈现出均匀的颗粒状结构和丰富的孔道结构，具有高电位和良好的极限电流，拥有优良的稳定性。所采用的合成方法，操作简便，成本低廉，且制备时间短，有利于实现大规模商业化生产。
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| GB/T 7714 | 肖高 , 胡钰花 . 一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料的制备及应用 : CN202210409833.8[P]. | 2022-04-19 00:00:00 . |
| MLA | 肖高 等. "一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料的制备及应用" : CN202210409833.8. | 2022-04-19 00:00:00 . |
| APA | 肖高 , 胡钰花 . 一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料的制备及应用 : CN202210409833.8. | 2022-04-19 00:00:00 . |
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本发明公开了一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极电催化剂材料及其制备方法，所述纳米材料活性物质为Cr‑La/CCF‑BT。燃料电池催化剂目前普遍面临着，前驱体单一和合成成本高昂的问题，而商业铂碳催化剂不仅成本高且稳定性差。为克服这些问题，本发明涉及一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极材料的制备，所述材料采用生物模板法，以La‑MOFs稀土金属有机框架修饰改性的废铬屑为模板和碳源，杨梅单宁作为前驱体制备连接La‑MOFs和废铬屑生物模板的桥梁分子，利用废铬屑本身天然的纤维态分级结构制备出具有天然独特形貌的La(MOFs)‑BT@Cr‑CF纳米复合材料前驱体，经高温煅烧最终形成Cr‑La/CCF‑BT。
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| GB/T 7714 | 肖高 , 胡钰花 . 一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极材料的制备 : CN202210873340.X[P]. | 2022-07-21 00:00:00 . |
| MLA | 肖高 等. "一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极材料的制备" : CN202210873340.X. | 2022-07-21 00:00:00 . |
| APA | 肖高 , 胡钰花 . 一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极材料的制备 : CN202210873340.X. | 2022-07-21 00:00:00 . |
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本发明公开了一种稀土多酚超分子包覆的共价有机聚合物铈基纳米碳球及其制备方法和应用。通过多酚网络的功能化改性手段，将Ce基金属有机框架与共价有机聚合物碳球紧密结合，得到具有优异氧化还原性能的纳米复合材料COP‑HB@CeMOF‑BT。本发明有效改善了Ce基催化剂的电化学性能，实现了稀土多酚网络与共价有机聚合物的独特协同作用。制得的纳米复合材料作为燃料电池催化剂具有高电位、优异的极限电流、优良的稳定性以及优异的甲醇耐受性等优点，应用前景广阔。
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| GB/T 7714 | 肖高 , 胡凡莹 , 刘明华 . 一种稀土多酚超分子包覆的共价有机聚合物铈基纳米碳球 : CN202111230306.2[P]. | 2021-10-22 00:00:00 . |
| MLA | 肖高 等. "一种稀土多酚超分子包覆的共价有机聚合物铈基纳米碳球" : CN202111230306.2. | 2021-10-22 00:00:00 . |
| APA | 肖高 , 胡凡莹 , 刘明华 . 一种稀土多酚超分子包覆的共价有机聚合物铈基纳米碳球 : CN202111230306.2. | 2021-10-22 00:00:00 . |
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本发明提供一种基于酵母菌碳模板构筑多孔铁纳米复合碳材料的方法，属于氧还原电催化技术领域。利用价廉易得的微生物酵母菌为碳模板，开发了以单宁酸络合铁离子的金属多酚超分子为表面黏附功能组装模块为基元，继而在氮气氛下高温碳化处理而得的多孔铁基碳纳米复合材料CTA‑Yeast@Fe NPs。该方法制备工艺简单、成本低、催化剂得率高、形貌均一、比表面积大。多孔铁纳米复合碳材料CTA‑Yeast@Fe NPs作为氧还原电催化剂具有较高起始电位、半坡电位、优异的极限电流以及高稳定性和较强的抗甲醇中毒能力，可替代传统商业Pt/C的高效电催化剂，具有很大的潜在应用价值和产业化前景。
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| GB/T 7714 | 肖高 , 张佳敏 , 刘明华 . 一种基于酵母菌碳模板构筑多孔铁纳米复合碳材料的方法 : CN202210080932.6[P]. | 2022-01-24 00:00:00 . |
| MLA | 肖高 等. "一种基于酵母菌碳模板构筑多孔铁纳米复合碳材料的方法" : CN202210080932.6. | 2022-01-24 00:00:00 . |
| APA | 肖高 , 张佳敏 , 刘明华 . 一种基于酵母菌碳模板构筑多孔铁纳米复合碳材料的方法 : CN202210080932.6. | 2022-01-24 00:00:00 . |
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本发明公开了一种处理利福平抗生素的铁钴多酚超分子改性有机框架复合材料及其制备方法。所述一种处理利福平抗生素的铁钴多酚超分子改性有机框架复合材料为MIL‑53(Fe)@TA‑Co。本发明的方法合成方法简单，反应条件温和，是一种经济有效的方法。能将此MIL‑53(Fe)@TA‑Co直接作为处理利福平的新型复合材料。解决现有利福平分子去除材料和方法少的现状，用本发明提供的新型复合吸附剂材料具有良好的吸附性能。MIL‑53(Fe)@TA‑Co作为利福平分子去除材料具有很大的潜在应用价值。
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| GB/T 7714 | 肖高 , 杨帆 , 刘明华 . 一种处理利福平抗生素的铁钴多酚超分子改性有机框架复合材料及其制备方法 : CN202210080920.3[P]. | 2022-01-24 00:00:00 . |
| MLA | 肖高 等. "一种处理利福平抗生素的铁钴多酚超分子改性有机框架复合材料及其制备方法" : CN202210080920.3. | 2022-01-24 00:00:00 . |
| APA | 肖高 , 杨帆 , 刘明华 . 一种处理利福平抗生素的铁钴多酚超分子改性有机框架复合材料及其制备方法 : CN202210080920.3. | 2022-01-24 00:00:00 . |
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Formononetin is a flavonoid compound with anti-tumor and anti-inflammatory properties. However, its low solubility limits its clinical use. We employed microfluidic technology to prepare formononetin-loaded PLGA-PEGDA microspheres (Degradable polymer PLGA, Crosslinking agent PEGDA), which can encapsulate and release drugs in a controlled manner. We optimized and characterized the microspheres, and evaluated their antitumor effects. The microspheres had uniform size, high drug loading efficiency, high encapsulation efficiency, and stable release for 35 days. They also inhibited the proliferation, migration, and apoptosis. The antitumor mechanism involved the induction of reactive oxygen species and modulation of Bcl-2 family proteins. These findings suggested that formononetin-loaded PLGA-PEGDA microspheres, created using microfluidic technology, could be a novel drug delivery system that can overcome the limitations of formononetin and enhance its antitumor activity.
Keyword ：
anti-tumor anti-tumor formononetin formononetin lung cancer lung cancer microfluidic microfluidic microspheres microspheres
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| GB/T 7714 | Cao, Xia , Li, Qingwen , Li, Xiaoli et al. Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication [J]. | AAPS PHARMSCITECH , 2023 , 24 (8) . |
| MLA | Cao, Xia et al. "Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication" . | AAPS PHARMSCITECH 24 . 8 (2023) . |
| APA | Cao, Xia , Li, Qingwen , Li, Xiaoli , Liu, Qi , Liu, Kai , Deng, Tianwen et al. Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication . | AAPS PHARMSCITECH , 2023 , 24 (8) . |
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Emodin is applied as an antitumor drug in many tumor therapies. However, its pharmacology performances are limited due to its low solubility. Herein, we fused erythrocyte and macrophage to form a hybrid membrane (EMHM) and encapsulated emodin to form hybrid membrane-coated nanoparticles. We employed glycyrrhizin to increase the solubility of emodin first and prepared the hybrid membrane nanoparticle-coated emodin and glycyrrhizin (EG@EMHM NPs) which exhibited an average particle size of 170 +/- 20 nm and encapsulation efficiency of 98.13 +/- 0.67%. The half-inhibitory concentrations (IC50) of EG@EMHM NPs were 1.166 mu g/mL, which is half of the free emodin. Based on the photosensitivity of emodin, the reactive oxygen species (ROS) results disclosed that ROS levels of the photodynamic therapy (PDT) section were higher than the normal section (P < 0.05). Compared to the normal section, PDT-mediated EG@EMHM NPs could induce an early stage of apoptosis of B16. The western blot and flow cytometry results verified that PDT-mediated EG@EMHM NPs can significantly improve the solubility of emodin and perform a remarkably antitumor effect on melanoma via BAX and BCL-2 pathway. The application of the combined chemical and PDT therapy could provide an improving target therapy for cutaneous melanoma and also may offer an idea for other insoluble components sources of traditional Chinese medicine.
Keyword ：
emodin emodin enhanced antitumor effect enhanced antitumor effect glycyrrhizin glycyrrhizin hybrid membrane hybrid membrane photodynamic therapy photodynamic therapy
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| GB/T 7714 | Cao, Xia , Deng, Tianwen , Zhu, Qin et al. Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy [J]. | AAPS PHARMSCITECH , 2023 , 24 (6) . |
| MLA | Cao, Xia et al. "Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy" . | AAPS PHARMSCITECH 24 . 6 (2023) . |
| APA | Cao, Xia , Deng, Tianwen , Zhu, Qin , Wang, Jianping , Shi, Wenwan , Liu, Qi et al. Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy . | AAPS PHARMSCITECH , 2023 , 24 (6) . |
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Bisdemethoxycurcumin (BDMC) is the main active ingredient that is isolated from Zingiberaceae plants, wherein it has excellent anti-tumor effects. However, insolubility in water limits its clinical application. Herein, we reported a microfluidic chip device that can load BDMC into the lipid bilayer to form BDMC thermosensitive liposome (BDMC TSL). The natural active ingredient glycyrrhizin was selected as the surfactant to improve solubility of BDMC. Particles of BDMC TSL had small size, homogenous size distribution, and enhanced cultimulative release in vitro. The anti-tumor effect of BDMC TSL on human hepatocellular carcinomas was investigated via 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method, live/dead staining, and flowcytometry. These results showed that the formulated liposome had a strong cancer cell inhibitory, and presented a dose-dependent inhibitory effect on migration. Further mechanistic studies showed that BDMC TSL combined with mild local hyperthermia could significantly upregulate B cell lymphoma 2 associated X protein levels and decrease B cell lymphoma 2 protein levels, thereby inducing cell apoptosis. The BDMC TSL that was fabricated via microfluidic device were decomposed under mild local hyperthermia, which could beneficially enhance the anti-tumor effect of raw insoluble materials and promote translation of liposome.
Keyword ：
Antitumor Antitumor Bisdemethoxycurcumin Bisdemethoxycurcumin Glycyrrhizin Glycyrrhizin Microfluidic Microfluidic Thermosensitive liposomes Thermosensitive liposomes
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| GB/T 7714 | Cao, Xia , Liu, Qi , Shi, Wenwan et al. Microfluidic fabricated bisdemethoxycurcumin thermosensitive liposome with enhanced antitumor effect [J]. | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2023 , 641 . |
| MLA | Cao, Xia et al. "Microfluidic fabricated bisdemethoxycurcumin thermosensitive liposome with enhanced antitumor effect" . | INTERNATIONAL JOURNAL OF PHARMACEUTICS 641 (2023) . |
| APA | Cao, Xia , Liu, Qi , Shi, Wenwan , Liu, Kai , Deng, Tianwen , Weng, Xuedi et al. Microfluidic fabricated bisdemethoxycurcumin thermosensitive liposome with enhanced antitumor effect . | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2023 , 641 . |
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Glioma, in which a malignant tumor cell occurs in neural mesenchymal cells, has a rapid progression and poor prognosis, which is still far from desirable in clinical treatments. We developed a lab-on-a-chip (LOC) device for the rapid and efficient preparation of vitexin/indocyanine green (ICG) liposomes. Vitexin could be released from liposome to kill cancer cell, which can potentially improve the glioma therapeutic effect and reduce the treatment time through synergistic photodynamic/photothermal therapies (PDT/PTT). The vitexin/ICG liposome was fabricated via LOC and its physicochemical property and release in vitro were evaluated. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and live/dead staining were used to examine the enhanced antitumor effect of vitexin/ICG liposome in cooperation with PDT/PTT, while the related mechanism was explored by flow cytometry and western blot. The results were as follows: (1) The prepared vitexin/ICG liposome was smaller in size, homogenous in particle size distribution with significant low polydispersity index (PDI), and enhanced cumulative release in vitro. (2) We found that the formulated liposome presented strong cancer cell inhibition and suppression of its migration in a dose-dependent manner. (3) Further mechanistic studies showed that liposome combined with near-infrared irradiation could significantly upregulate levels of B cell lymphoma 2-associated X (Bax) protein and decrease B cell lymphoma 2 (Bcl-2) at protein levels. The vitexin/ICG liposomes prepared based on a simple LOC platform can effectively enhance the solubility of insoluble drugs, and the combined effect of PTT/PDT can effectively increase their antitumor effect, which provides a simple and valid method for the clinical translation of liposomes.
Keyword ：
indocyanine green indocyanine green lab-on-a-chip lab-on-a-chip liposome liposome near-infrared ray near-infrared ray vitexin vitexin
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| GB/T 7714 | Cao, Xia , Liu, Qi , Adu-Frimpong, Michael et al. Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy [J]. | AAPS PHARMSCITECH , 2023 , 24 (4) . |
| MLA | Cao, Xia et al. "Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy" . | AAPS PHARMSCITECH 24 . 4 (2023) . |
| APA | Cao, Xia , Liu, Qi , Adu-Frimpong, Michael , Shi, Wenwan , Liu, Kai , Deng, Tianwen et al. Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy . | AAPS PHARMSCITECH , 2023 , 24 (4) . |
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The emission of volatile organic compounds (VOCs) has resulted in increasingly severe harm to the environment and human health. In recent years, biological methods have become the preferred technology for VOC removal due to their environmental friendliness and economic advantages. Based on the theory of bibliometrics, this study analyzed research articles and reviews on biological methods for VOC removal published in the Web of Science Core Collection (WOSCC) database from 1966 to 2021. The knowledge map visualization software CiteSpace was utilized to analyze research progress in different countries, co-citation clustering, co-citation bursts, and keyword clustering in the literature data. The results indicated that early research on VOC biological treatment focused on the removal of odorous gases and single components of volatile organic waste gases. Subsequently, benzene contents (BTEX), hydrophobic VOCs, and multi-component VOCs have gradually become the focus of research. In recent years, improving VOC removal efficiency by studying packing materials and microbial communities has become an important research topic both domestically and internationally. Future research should focus on continuously improving the performance of reactors, developing novel reactors, and investigating technologies for treating complex and recalcitrant VOCs.
Keyword ：
bibliometrics bibliometrics biological methods biological methods CiteSpace CiteSpace clustering analysis clustering analysis volatile organic compounds volatile organic compounds
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| GB/T 7714 | Wang, Yuan , Zhou, Bin , Yang, Mengrong et al. Bibliometrics and Knowledge Map Analysis of Research Progress on Biological Treatments for Volatile Organic Compounds [J]. | SUSTAINABILITY , 2023 , 15 (12) . |
| MLA | Wang, Yuan et al. "Bibliometrics and Knowledge Map Analysis of Research Progress on Biological Treatments for Volatile Organic Compounds" . | SUSTAINABILITY 15 . 12 (2023) . |
| APA | Wang, Yuan , Zhou, Bin , Yang, Mengrong , Xiao, Gao , Xiao, Hang , Dai, Xiaorong . Bibliometrics and Knowledge Map Analysis of Research Progress on Biological Treatments for Volatile Organic Compounds . | SUSTAINABILITY , 2023 , 15 (12) . |
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