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学者姓名：林旭聪
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Abstract ：
Developing a functional media for precise identification of trace shellfish toxin would underpin the effective assessment of marine pollution. Herein, a novel monolithic column with a dual-mode strategy integrating antifouling and aptamer bionic affinity recognition was proposed for online specific identification of the marine toxin okadaic acid (OA). The zwitterionic monomer 2-(methacryloyloxy)ethylphosphorylcholine (MPC) and aptamers were synergistically employed to enable efficient reduction of matrix interferences and selective capture of target OA. Preparation optimization, characterization, and fouling-resistant mechanism of the dualmode bionic monolith were evaluated. The zwitterion phosphorylcholine MPC introduced into the monolith significantly improved the fouling resistance to biomass substrates, meanwhile the aptamers were able to provide a high specific recognition capacity. Coupled with LC-MS, the as-prepared monolith provided an effective approach for highly selective and sensitive identification of OA. Good recovery yields of over 90 % in shellfish tissue extracts and human serum were achieved with a sensitive limit of detection (LOD) as low as 0.1 ng/mL, as well as excellent specificity and low interference from proteins, fatty acids and analogues. Applied to popular shellfishes (such as clams, mussels, and oysters) and serum samples, trace OA toxin was accurately distinguished and quantified with satisfactory recoveries as 93.8 +/- 2.2 % - 99.9 +/- 1.9 % (n = 3). Compared to the traditional HLB cartridge and other materials in the LC-MS method, the resulting anti-fouling aptamer monolith provided a more advanced online analysis mode with higher sensitivity and better resolution of OA in biological samples. It might provide an attractive access to an online bionic recognition platform with LC-MS for efficient, antiinterference and sensitive specific detection of trace marine toxin OA in biological samples.
Keyword ：
Aptamer affinity monolith Aptamer affinity monolith Dual mode Dual mode Okadaic acid Okadaic acid Online recognition Online recognition Zwitterion antifouling Zwitterion antifouling
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| GB/T 7714 | Peng, Qi , Ye, Yan , Wu, Xinglin et al. Dual-mode monolithic column with zwitterion antifouling and aptamer affinity for online specific recognition of okadaic acid [J]. | JOURNAL OF CHROMATOGRAPHY A , 2025 , 1747 . |
| MLA | Peng, Qi et al. "Dual-mode monolithic column with zwitterion antifouling and aptamer affinity for online specific recognition of okadaic acid" . | JOURNAL OF CHROMATOGRAPHY A 1747 (2025) . |
| APA | Peng, Qi , Ye, Yan , Wu, Xinglin , Lin, Chenchen , Lin, Xucong , Weng, Qibiao et al. Dual-mode monolithic column with zwitterion antifouling and aptamer affinity for online specific recognition of okadaic acid . | JOURNAL OF CHROMATOGRAPHY A , 2025 , 1747 . |
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The advancement in miniaturized Raman spectrometers, coupled with the single-molecule-level sensitivity and unique fingerprint identification capability of surface-enhanced Raman scattering (SERS), offers great potential for point-of-care testing (POCT). Despite this, accurately quantifying analyte molecules, particularly in complex samples with limited sample volumes, remains difficult. Herein, we present a versatile and reusable SERS microplatform for highly sensitive and reliable quantitative detection of adenosine triphosphate (ATP) in biological fluids. The platform utilizes gold-Prussian blue core-shell nanoparticles modified with polyethyleneimine (Au@PB@PEI NPs), embedded within gold nanoparticle-immobilized capillary-based silica monolithic materials. PB acts as an internal standard, while PEI enhances molecular capture. The periodic, bimodal porous structure of the silica monolithic materials provides uniform and abundant sites for nanoparticle attachment, facilitating rapid liquid permeation, intense SERS enhancement, and efficient enrichment. The platform regulates ATP capture and release through magnesium ions in the liquid phase, eliminating matrix interferences and enabling platform reuse. Integrating efficient molecular enrichment, separation, an interference-free internal standard, a liquid flow channel, and a detection chamber, our platform offers simplicity in operation, exceptional sensitivity and accuracy, and rapid analysis (∼10 min). Employing PB as an internal calibration standard, ratiometric Raman signals (I732/I2123) facilitate precise ATP quantification, achieving a remarkable limit of detection down to 0.62 pM. Furthermore, this platform has been proven to be highly reproducible and validated for ATP quantification in both mouse cerebrospinal fluid and human serum, underscoring its immense potential for POCT applications. © 2024
Keyword ：
Adenosine triphosphate quantification Adenosine triphosphate quantification Multifunction integration Multifunction integration Point-of-care testing application Point-of-care testing application Reusability Reusability Surface-enhanced Raman scattering microplatform Surface-enhanced Raman scattering microplatform
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| GB/T 7714 | Chi, J. , Xie, Q. , Huang, G. et al. Versatile, reusable and highly sensitive SERS-based point-of-care testing microplatform for reliable ATP detection [J]. | Biosensors and Bioelectronics , 2024 , 265 . |
| MLA | Chi, J. et al. "Versatile, reusable and highly sensitive SERS-based point-of-care testing microplatform for reliable ATP detection" . | Biosensors and Bioelectronics 265 (2024) . |
| APA | Chi, J. , Xie, Q. , Huang, G. , Xie, S. , Lin, X. . Versatile, reusable and highly sensitive SERS-based point-of-care testing microplatform for reliable ATP detection . | Biosensors and Bioelectronics , 2024 , 265 . |
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Accurate quantitation of trace-level ATP biomarkers often suffers from interference of sample matrix and remains a challenge. Herein, a novel magnetic biological nanosensor (MBNS) integrating tetrahedral framework nucleic acid (tFNA)-confined aptamers and ultrasensitive laser-induced fluorescence (LIF) was tailored and evaluated. The fluorescent aptamer nanoprobe hybridized with FAM-labelled cDNA was particularly incorporated into the inner cavity of tFNA, enabling a dual-mode mechanism that integrates molecular size selection and aptamer affinity recognition. By this strategy, the benefits of tFNA molecular sieve, the super sensitive properties of LIF, and the specific recognition of 'aptamer gene codes' were integrated, as triggered the superior response of ATP. The structures, properties and reaction mechanism of tFNA, as well as tFNA modified with aptamer probe at different sites, were characterized in detail. A high level of anti-interference was achieved, shielding against non-specific adsorption even in matrices with high protein and analogue content, 103∼105 times higher than ATP. The release of fluorescent beacon from aptamer probe was facilely driven by specific binding of ATP, and an ultra-sensitive detection of 75 pmol/L ATP was obtained without amplification. It was 2–3 orders of magnitude more sensitive than most fluorescent aptasensors. Applied to serum samples, the stability and reproducibility of the resultant aptasensor have been validated with the intra- and inter-assay RSD in 1.6–6.4 % and -1.5–8.4 %, respectively. Acceptable recoveries of 96.5–106.8 % were achieved, consistent with the LC-MS method. It was expected to open a simple and efficient protocol for highly specific and ultrasensitive ATP detection in clinical diagnostics. © 2024 Elsevier B.V.
Keyword ：
Biomolecules Biomolecules Fluorescence Fluorescence Ion beams Ion beams Laser optics Laser optics Laser produced plasmas Laser produced plasmas Nucleic acids Nucleic acids Probes Probes
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| GB/T 7714 | Huang, Guobin , Xie, Qian , Chi, Jinxin et al. Magneto-fluorescent nanobiosensor with tetrahedral framework nucleic acid-confined aptamer for trace adenosine triphosphate detection [J]. | Sensors and Actuators B: Chemical , 2024 , 417 . |
| MLA | Huang, Guobin et al. "Magneto-fluorescent nanobiosensor with tetrahedral framework nucleic acid-confined aptamer for trace adenosine triphosphate detection" . | Sensors and Actuators B: Chemical 417 (2024) . |
| APA | Huang, Guobin , Xie, Qian , Chi, Jinxin , Lin, Chenchen , Lin, Xucong , Xie, Zenghong . Magneto-fluorescent nanobiosensor with tetrahedral framework nucleic acid-confined aptamer for trace adenosine triphosphate detection . | Sensors and Actuators B: Chemical , 2024 , 417 . |
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Okadaic acid (OA) biotoxin acts a well-established inhibitor of protein phosphatase even a tumor promoter of human being, arouse great attention in safety monitoring. However, the powerful and convenient nanosensing technologies for addressing the demands such as rapidity, high sensitivity, and stability in the in-field test of OA shellfish toxin is still scarce. Herein, a high-performance magnetic biometric nanosensor (MBNS) integrating oriented aptamers and ultrasensitive laser-induced fluorescence (LIF) was firstly proposed for the in-field detection of trace OA in seafoods. High-density aptamers hybridized with FAM-labeled cDNA were tethered to the surface of AuNPs on magnetic MIL-101@Fe3O4, and then finely regulated by mercaptohexyl alcohol (MCH) to be orderly assembled, as was successfully utilized to engineer an active biological nanosensor for highly specific recognition of OA. Aptamers anchored on magnetic Fe3O4@MOF@AuNPs activate a biometric micro -reactor of OA, in which the superior LIF properties, conformation regulation of aptamer, and the specific recognition using aptamer genes were adopted. The magnetic nanosensor with an excellent specificity and super sensitivity for OA analysis was achieved within 20 min. Moreover, the content of captured OA could facilely be recorded by measuring the fluorescence intensity, and the limit of detection (LOD) and limit of quantitation of OA (LOQ) reached 0.015 and 0.050 ng/mL respectively, which was far better than most aptamer-based biometric sensing methods. The feasibility for accurate test of trace OA toxin in the fortified shellfish samples was validated with the recovery yields of 88.2-107.5% and RSD of 0.5-7.6%, respectively. The result demonstrated that the oriented-aptamer encoded MNS had significant practical values in rapid and ultrasensitive detection of OA biotoxin and the related safety applications.
Keyword ：
Laser-induced fluorescence Laser-induced fluorescence Magnetic nanosensor Magnetic nanosensor Okadaic acid Okadaic acid Oriented aptamer Oriented aptamer Ultrasensitive test Ultrasensitive test
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| GB/T 7714 | Zhou, Yuwei , Chen, Qingai , Huang, Guobin et al. Oriented-aptamer encoded magnetic nanosensor with laser-induced fluorescence for ultrasensitive test of okadaic acid [J]. | TALANTA , 2024 , 266 . |
| MLA | Zhou, Yuwei et al. "Oriented-aptamer encoded magnetic nanosensor with laser-induced fluorescence for ultrasensitive test of okadaic acid" . | TALANTA 266 (2024) . |
| APA | Zhou, Yuwei , Chen, Qingai , Huang, Guobin , Huang, Shukun , Lin, Chenchen , Lin, Xucong et al. Oriented-aptamer encoded magnetic nanosensor with laser-induced fluorescence for ultrasensitive test of okadaic acid . | TALANTA , 2024 , 266 . |
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The differentiation of 3-AminoPyrrolidine (3AP) and its derivative isomers is significant due to their use as intermediates in drug synthesis. However, the separation of these isomers, which exhibit both chiral and positional isomerism, has consistently posed challenges. In this study, an efficient analytical method was developed to discrimination between the four isomers of R/S-I/N-Boc-3-AminoPyrrolidine (R/S-l/N-Boc-3AP) and four groups of derived chiral isomers, namely R/S-N-Methyl-3-AminoPyrrolidine (R/S-N-Me-3AP), R/S-N-Ethyl-3AminoPyrrolidine (R/S-N-Et-3AP), R/S-1-Bzl-3-AminoPyrrolidine (R/S-1-Bzl-3AP), and R/S-1-Cbz-3AminoPyrrolidine (R/S-1-Cbz-3AP). The discrimination was achieved by utilizing natamycin (Nat) as a differentiation agent and 2/3/4-aminobenzenesulphonic acid (2/3/4-ABSA) as ligand. The facile discrimination of the four positional isomers of R/S-1-Boc-3AP and R/S-N-Boc-3AP was achieved using ion mobility spectrometry (IMS) based on their formed diastereomeric complexes [Nat + (Boc-3AP)2 + (2-ABSA)2 + H]+. The isomers were also studied via tandem mass spectrometry (MS/MS) using the formed ternary complexes, different fragment ions were observed for l-Boc-3AP and N-Boc-3AP, but the R/S enantiomers cannot be discriminated either. In addition, the enantiomers R/S-l-Bzl-3AP and R/S-l-Cbz-3AP were differentiated based on mobility using [Nat + (R/Sl-Bzl-3AP) + (3-ABSA)2 + H]+ and [Nat + (R/S-l-Cbz-3AP) + 2-ABSA + H]+; however for the small enantiomeric molecules of R/S-N-Me-3AP and R/S-N-Et-3AP, chiral discrimination was not achieved via the ternary complexes of Nat + R/S-N-Me-3AP-ABSA and Nat + R/S-N-Et-3AP-ABSA. Importantly, the separation was greatly improved by the coordinated alkali metal ions, where the separation resolution (Rp-p) increased with the radius of the metal ions. Finally, quantitative analysis and method validation were carried out for the four Boc-3AP isomers using both MS/MS and IMS-MS. Overall, the proposed method opens possibilities for the rapid discrimination and quantification of isomers exhibiting both chiral and positional isomerism in MS/MS and IMS-MS analyses.
Keyword ：
3-AminoPyrrolidine derivatives 3-AminoPyrrolidine derivatives Chiral and positional isomerism Chiral and positional isomerism Diastereomeric complexes Diastereomeric complexes Differentiation Differentiation Ion mobility spectrometry Ion mobility spectrometry
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| GB/T 7714 | He, Sisi , Liu, Yiyi , Chi, Chaoxian et al. Discrimination of 3-aminopyrrolidine derivatives with chiral and positional isomerism through mobility disparity based on non-covalent interactions [J]. | MICROCHEMICAL JOURNAL , 2024 , 197 . |
| MLA | He, Sisi et al. "Discrimination of 3-aminopyrrolidine derivatives with chiral and positional isomerism through mobility disparity based on non-covalent interactions" . | MICROCHEMICAL JOURNAL 197 (2024) . |
| APA | He, Sisi , Liu, Yiyi , Chi, Chaoxian , Zhou, Dongdong , Ding, Chuan-Fan , Lin, Xucong et al. Discrimination of 3-aminopyrrolidine derivatives with chiral and positional isomerism through mobility disparity based on non-covalent interactions . | MICROCHEMICAL JOURNAL , 2024 , 197 . |
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Abstract ：
The advancement in miniaturized Raman spectrometers, coupled with the single-molecule-level sensitivity and unique fingerprint identification capability of surface-enhanced Raman scattering (SERS), offers great potential for point-of-care testing (POCT). Despite this, accurately quantifying analyte molecules, particularly in complex samples with limited sample volumes, remains difficult. Herein, we present a versatile and reusable SERS microplatform for highly sensitive and reliable quantitative detection of adenosine triphosphate (ATP) in biological fluids. The platform utilizes gold-Prussian blue core-shell nanoparticles modified with polyethyleneimine (Au@PB@PEI NPs), embedded within gold nanoparticle-immobilized capillary-based silica monolithic materials. PB acts as an internal standard, while PEI enhances molecular capture. The periodic, bimodal porous structure of the silica monolithic materials provides uniform and abundant sites for nanoparticle attachment, facilitating rapid liquid permeation, intense SERS enhancement, and efficient enrichment. The platform regulates ATP capture and release through magnesium ions in the liquid phase, eliminating matrix interferences and enabling platform reuse. Integrating efficient molecular enrichment, separation, an interference-free internal standard, a liquid flow channel, and a detection chamber, our platform offers simplicity in operation, exceptional sensitivity and accuracy, and rapid analysis (similar to 10 min). Employing PB as an internal calibration standard, ratiometric Raman signals (I-732/I-2123) facilitate precise ATP quantification, achieving a remarkable limit of detection down to 0.62 pM. Furthermore, this platform has been proven to be highly reproducible and validated for ATP quantification in both mouse cerebrospinal fluid and human serum, underscoring its immense potential for POCT applications.
Keyword ：
Adenosine triphosphate quantification Adenosine triphosphate quantification microplatform microplatform Multifunction integration Multifunction integration Point-of-care testing application Point-of-care testing application Reusability Reusability Surface-enhanced Raman scattering Surface-enhanced Raman scattering
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| GB/T 7714 | Chi, Jinxin , Xie, Qian , Huang, Guobin et al. Versatile, reusable and highly sensitive SERS-based point-of-care testing microplatform for reliable ATP detection [J]. | BIOSENSORS & BIOELECTRONICS , 2024 , 265 . |
| MLA | Chi, Jinxin et al. "Versatile, reusable and highly sensitive SERS-based point-of-care testing microplatform for reliable ATP detection" . | BIOSENSORS & BIOELECTRONICS 265 (2024) . |
| APA | Chi, Jinxin , Xie, Qian , Huang, Guobin , Xie, Shulun , Lin, Xucong , Huang, Guihua . Versatile, reusable and highly sensitive SERS-based point-of-care testing microplatform for reliable ATP detection . | BIOSENSORS & BIOELECTRONICS , 2024 , 265 . |
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Abstract ：
Accurate quantitation of trace-level ATP biomarkers often suffers from interference of sample matrix and remains a challenge. Herein, a novel magnetic biological nanosensor (MBNS) integrating tetrahedral framework nucleic acid (tFNA)-confined aptamers and ultrasensitive laser-induced fluorescence (LIF) was tailored and evaluated. The fluorescent aptamer nanoprobe hybridized with FAM-labelled cDNA was particularly incorporated into the inner cavity of tFNA, enabling a dual-mode mechanism that integrates molecular size selection and aptamer affinity recognition. By this strategy, the benefits of tFNA molecular sieve, the super sensitive properties of LIF, and the specific recognition of "aptamer gene codes" were integrated, as triggered the superior response of ATP. The structures, properties and reaction mechanism of tFNA, as well as tFNA modified with aptamer probe at different sites, were characterized in detail. A high level of anti-interference was achieved, shielding against nonspecific adsorption even in matrices with high protein and analogue content, 10(3)similar to 10(5) times higher than ATP. The release of fluorescent beacon from aptamer probe was facilely driven by specific binding of ATP, and an ultra-sensitive detection of 75 pmol/L ATP was obtained without amplification. It was 2-3 orders of magnitude more sensitive than most fluorescent aptasensors. Applied to serum samples, the stability and reproducibility of the resultant aptasensor have been validated with the intra- and inter-assay RSD in 1.6-6.4 % and -1.5-8.4 %, respectively. Acceptable recoveries of 96.5-106.8 % were achieved, consistent with the LC-MS method. It was expected to open a simple and efficient protocol for highly specific and ultrasensitive ATP detection in clinical diagnostics.
Keyword ：
Aptamer affinity Aptamer affinity Aptasensor Aptasensor Laser-induced fluorescence Laser-induced fluorescence Size selection Size selection Tetrahedral framework nucleic acid Tetrahedral framework nucleic acid
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| GB/T 7714 | Huang, Guobin , Xie, Qian , Chi, Jinxin et al. Magneto-fluorescent nanobiosensor with tetrahedral framework nucleic acid-confined aptamer for trace adenosine triphosphate detection [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 417 . |
| MLA | Huang, Guobin et al. "Magneto-fluorescent nanobiosensor with tetrahedral framework nucleic acid-confined aptamer for trace adenosine triphosphate detection" . | SENSORS AND ACTUATORS B-CHEMICAL 417 (2024) . |
| APA | Huang, Guobin , Xie, Qian , Chi, Jinxin , Lin, Chenchen , Lin, Xucong , Xie, Zenghong . Magneto-fluorescent nanobiosensor with tetrahedral framework nucleic acid-confined aptamer for trace adenosine triphosphate detection . | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 417 . |
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Androgenetic alopecia (AGA) is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment, leading to cell apoptosis and eventual loss of hair follicles (HFs). Traditional therapeutic formulations, such as Minoxidil (MXD) tincture, have limitations in reshaping the perifollicular microenvironment and exhibit limited effectiveness. Here, we report a multi-synergistic therapeutic platform for high-performance hair regeneration therapy. The platform combines microneedle (MN) patches loaded with MXD-encapsulated nanostructured lipid carriers (MXD-NLC-MNs) and cold atmospheric plasma (CAP). The MNs' mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells, promoting cell proliferation. Furthermore, in collaboration with MXD, the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor, leading to neoangiogenesis. Meanwhile, the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAP-generated nitric oxide (NO) to the sites of HF lesions, whereby the synergistic interaction between MXD and NO boosts perifollicular vasodilation. Consequently, the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine models. This multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.
Keyword ：
androgenetic alopecia androgenetic alopecia cold atmospheric plasma cold atmospheric plasma drug delivery drug delivery microneedle microneedle nanomedicine nanomedicine
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| GB/T 7714 | Chen, Hao , Tang, Xianzhe , Huang, Yueye et al. Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia [J]. | NANO RESEARCH , 2024 , 17 (7) : 6411-6419 . |
| MLA | Chen, Hao et al. "Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia" . | NANO RESEARCH 17 . 7 (2024) : 6411-6419 . |
| APA | Chen, Hao , Tang, Xianzhe , Huang, Yueye , Chen, Chen , Yang, Yuheng , Hao, Chaojie et al. Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia . | NANO RESEARCH , 2024 , 17 (7) , 6411-6419 . |
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Sensitive detection of dopamine (DA) is essential for the diagnosis of nervous system diseases. Herein, a nanozyme-based colorimetric platform for DA determination was proposed. Using an imine-type covalent organic framework (COF-TD) as a host matrix, a nanozyme (AgNPs@COF-TD) was fabricated by anchoring silver nanoparticles (AgNPs) on the surface of COF-TD via in situ reduction of silver ions. Various characterization results confirmed the successful synthesis of flower-like AgNPs@COF-TD with surface-anchored AgNPs, which could expose more active sites. The as-prepared AgNPs@COF-TD exhibited satisfactory oxidase-mimicking activity with a low Km, which could catalyze the oxidation of colorless 3,3 ',5,5 '-tetramethylbenzidine (TMB) to blue oxidized TMB (oxTMB) with significant absorbance at 657 nm. The introduction of DA not only reduced blue oxTMB to colorless TMB but also competed with TMB for the active sites of AgNPs@COF-TD, making a significant decrease in absorbance. Therefore, a label-free sensing strategy based on the oxidase-mimicking activity of AgNPs@COF-TD was successfully established for the colorimetric detection of DA, with a detection limit down to 0.2 mu M. The practical applicability of this assay was further validated by analyzing DA-spiked human urine samples. This work provided a facile approach to prepare COF-based nanozymes, and demonstrated their great potential in colorimetric detection and bioanalysis.
Keyword ：
Colorimetric detection Colorimetric detection Covalent organic frameworks Covalent organic frameworks Dopamine Dopamine Oxidase-mimicking activity Oxidase-mimicking activity Silver nanoparticles Silver nanoparticles
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| GB/T 7714 | Jia, Zixiao , Shi, Dapeng , Wang, Jiabin et al. Covalent organic frameworks surface-anchored with silver nanoparticles for colorimetric detection of dopamine based on its oxidase-mimicking activity [J]. | MICROCHEMICAL JOURNAL , 2024 , 200 . |
| MLA | Jia, Zixiao et al. "Covalent organic frameworks surface-anchored with silver nanoparticles for colorimetric detection of dopamine based on its oxidase-mimicking activity" . | MICROCHEMICAL JOURNAL 200 (2024) . |
| APA | Jia, Zixiao , Shi, Dapeng , Wang, Jiabin , Lin, Xucong . Covalent organic frameworks surface-anchored with silver nanoparticles for colorimetric detection of dopamine based on its oxidase-mimicking activity . | MICROCHEMICAL JOURNAL , 2024 , 200 . |
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基于单糖与1-苯基-3-甲基-5-吡唑啉酮的柱前衍生，采用反相高效液相色谱（HPLC）梯度洗脱/紫外检测联用技术，建立了凉粉草多糖水解单糖的HPLC指纹图谱，用于凉粉草水提溶液中多糖水解单糖组分分析，鉴别测定了水解单糖组分中核糖、鼠李糖、葡萄糖醛酸、半乳糖醛酸、葡萄糖、半乳糖、木糖、阿拉伯糖等8种单糖含量，开展了不同地区的凉粉草多糖水解单糖的HPLC指纹图谱相似度分析、聚类分析和主成分分析。研究表明，不同地区凉粉草水解单糖组分中半乳糖、半乳糖醛酸和葡萄糖是样本聚类的重要变量，地区差异导致聚类分析差异，不同产地的凉粉草中多糖水解产生的单糖组分含量和分布具有一定的差异。方法可为凉粉草水提溶液中多糖水解单糖组分的评价提供一定的技术支持。
Keyword ：
HPLC HPLC 凉粉草 凉粉草 单糖 单糖 多糖 多糖 指纹图谱 指纹图谱
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| GB/T 7714 | 齐国敏 , 曹华斌 , 林旭聪 . 凉粉草多糖水解单糖成分的高效液相色谱指纹图谱分析 [J]. | 分析试验室 , 2023 , 42 (04) : 501-506 . |
| MLA | 齐国敏 et al. "凉粉草多糖水解单糖成分的高效液相色谱指纹图谱分析" . | 分析试验室 42 . 04 (2023) : 501-506 . |
| APA | 齐国敏 , 曹华斌 , 林旭聪 . 凉粉草多糖水解单糖成分的高效液相色谱指纹图谱分析 . | 分析试验室 , 2023 , 42 (04) , 501-506 . |
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