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学者姓名：翁祖铨
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Abstract ：
The rise of antibiotic-resistant bacteria poses a serious global health threat, highlighting the urgent need for novel strategies beyond conventional antibiotic therapies. This study explores the potential of microbe-imprinted polymers (MIPs) as innovative, pathogen-specific affinity agents. Utilizing microbial surface-initiated polymerization, MIPs are in-situ synthesized on the surface of target microbes, creating flexible heteropolymers that precisely replicate microbial surface structures. This method exhibits high affinity (KD = 2.7×108 CFU/mL for E. coli) and selectivity at the strain level. MIPs offer significant advantages over traditional antibodies, including greater stability, cost-effectiveness, and a broader spectrum of binding capabilities, making them effective for identifying and targeting various microbial strains, including unidentified or drug-resistant variants. Moreover, their favorable biocompatibility and functional resilience in diverse environments position MIPs as promising candidates for rapid pathogen detection and therapeutic applications. This research paves the way for advanced biomimetic materials in microbe-specific diagnostics and combating infections, addressing the critical need for effective tools in antibiotic resistance surveillance. © 2025
Keyword ：
Affinity Affinity Antibiotic resistance Antibiotic resistance Antibody mimics Antibody mimics Microbe-imprinted polymers Microbe-imprinted polymers Microbial recognition Microbial recognition
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| GB/T 7714 | Wu, Y. , Zhou, K. , Li, W. et al. Microbe-imprinted polymers for rapid drug-resistant bacteria recognition [J]. | Chemical Engineering Journal , 2025 , 512 . |
| MLA | Wu, Y. et al. "Microbe-imprinted polymers for rapid drug-resistant bacteria recognition" . | Chemical Engineering Journal 512 (2025) . |
| APA | Wu, Y. , Zhou, K. , Li, W. , Huan, M. , Yu, Z. , Yan, F. et al. Microbe-imprinted polymers for rapid drug-resistant bacteria recognition . | Chemical Engineering Journal , 2025 , 512 . |
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The persistence of T-2 toxin in food and feed matrices renders it a pervasive contaminant, impacting both human and animal health. Traditional detection methods suffer from cumbersome instrumentation and intricate procedures, rendering on-site detection of T-2 toxin unfeasible. Therefore, we have constructed a real-time detection method for T-2 toxin detection by employing a target-responsive DNA hydrogel in conjunction with potassium iodide starch test paper. This method integrates both colorimetric and distance-based signal outputs, offering a streamlined and effective approach for the on-site detection of T-2 toxin. The specific binding of the target to the aptamer in the DNA hydrogel results in the collapse of the hydrogels structure, which changes the viscosity of the system and released horseradish peroxidase in the hydrogel wrapped, and then produces blue-purple marks of different lengths on the starch iodide papers to achieve the specific detection of T-2 toxin. Under optimized conditions, the assay exhibits a detection range spanning from 10 ng/mL to 10 mg/mL for the toxin, with a detection limit of 12.83 ng/mL. The proposed method has been successfully applied for the detection of real corn samples with satisfied result. Such colorimetric-distance dual signal detection method offers notable advantages, including straightforward operation, clear signal interpretation, and practical utility. Its implementation enables rapid, on-the-spot detection of T-2 toxin, particularly beneficial in resource-limited regions and less developed countries.
Keyword ：
Point-of-care testing Point-of-care testing Starch iodide paper Starch iodide paper T-2 toxin T-2 toxin Target-responsive DNA hydrogel Target-responsive DNA hydrogel
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| GB/T 7714 | Deng, Ye , Lin, Jiarong , Wang, Jingxuan et al. Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper [J]. | MICROCHEMICAL JOURNAL , 2025 , 210 . |
| MLA | Deng, Ye et al. "Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper" . | MICROCHEMICAL JOURNAL 210 (2025) . |
| APA | Deng, Ye , Lin, Jiarong , Wang, Jingxuan , Lin, Yue , Luo, Fang , Weng, Zuquan et al. Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper . | MICROCHEMICAL JOURNAL , 2025 , 210 . |
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Abstract ：
The intracellular delivery of protein drugs via nanocarriers offers significant potential for expanding their therapeutic applications. However, the unintended activation of innate immune responses and inflammation triggered by the carriers presents a major challenge, often compromising therapeutic efficacy. Here, we present oligoethylenimine-thioketal (OEI-TK), a reactive oxygen species-responsive cationic polymer with intrinsic anti-inflammatory properties, to overcome this challenge. OEI-TK self-assembles electrostatically with bovine serum albumin (BSA) to form stable nanoparticles (OTB NPs) with excellent encapsulation efficiency. In vitro studies confirmed that OTB NPs retained OEI-TK's antioxidant and anti-inflammatory properties, enhanced biocompatibility, and efficiently delivered BSA into cells. Furthermore, OEI-TK facilitated the intracellular delivery of beta-galactosidase while preserving its enzymatic activity, demonstrating its potential for functional protein transport. These findings highlight OEI-TK as a promising platform with dual benefits of inflammation modulation and intracellular protein delivery, holding potential for the synergistic treatment of inflammation-related diseases.
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| GB/T 7714 | Wang, Yongming , Ming, Yangcan , Yu, Zhichao et al. ROS-Responsive Cationic Polymers with Intrinsic Anti-Inflammatory Activity for Intracellular Protein Delivery [J]. | BIOMACROMOLECULES , 2025 , 26 (4) : 2268-2281 . |
| MLA | Wang, Yongming et al. "ROS-Responsive Cationic Polymers with Intrinsic Anti-Inflammatory Activity for Intracellular Protein Delivery" . | BIOMACROMOLECULES 26 . 4 (2025) : 2268-2281 . |
| APA | Wang, Yongming , Ming, Yangcan , Yu, Zhichao , Xu, Zhenjin , Zou, Minglang , Chen, Cuiping et al. ROS-Responsive Cationic Polymers with Intrinsic Anti-Inflammatory Activity for Intracellular Protein Delivery . | BIOMACROMOLECULES , 2025 , 26 (4) , 2268-2281 . |
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Dual-signal point-of-care testing (POCT) method relying on multicolor changes have demonstrated a promising improvement in performance. In this work, we have developed a highly sensitive and rapid POCT method for detecting aflatoxin B1 (AFB1), utilizing a dual-signal readout mode based on temperature and multicolor changes. A synthetic enzyme mimics, Al-Cu-Santa Barbara Amorphous material (Al-Cu-SBA), has been used to enable the dual-signal changes of gold nanobipyramids (Au NBPs) for the first time. Specifically, the aptamer was immobilized on magnetic beads, facilitating hybridization with complementary strands functionalized with Al-Cu-SBA and hence forming double-stranded DNA. Upon introducing AFB1 into the system, it bound to the aptamer chain, resulting in the release of Al-Cu-SBA into solution. The liberated Al-Cu-SBA was subsequently collected and used to oxidize 3, 3′, 5, 5′-tetramethylbenzidine (TMB). The oxidized TMB was used to etch Au NBPs, inducing significant color changes. Meanwhile, by leveraging the photothermal properties of Au NBPs, we observed a temperature difference generated upon exposure to infrared laser irradiation. This method exhibited a linear range from 0.5 μg·mL−1 to 100 μg·mL−1, with a detection limit of 0.167 μg·mL−1. The method's applicability was extended to successfully detect AFB1 in both peanut oil and milk samples. Given the application of enzyme mimics and the dual-signal readout integrating temperature and multicolor changes, our study successfully overcomes the limitations inherent in traditional biological enzyme-based methods and the conventional single-signal readout approach. Additionally, it surpasses the limitations associated with dual-signal readout systems that rely solely on monochromatic colorimetric analysis. © 2024 Elsevier B.V.
Keyword ：
Aluminum Aluminum Amorphous materials Amorphous materials Colorimetry Colorimetry Copper Copper Enzymes Enzymes Silica Silica
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| GB/T 7714 | Zheng, Zhenjie , Zhan, Linxiu , Wang, Liang et al. Aluminium-copper-mesoporous silica molecular sieve-enabled dual-signal point-of-care aptasensor with integrated temperature and multicolor readout [J]. | Sensors and Actuators B: Chemical , 2024 , 418 . |
| MLA | Zheng, Zhenjie et al. "Aluminium-copper-mesoporous silica molecular sieve-enabled dual-signal point-of-care aptasensor with integrated temperature and multicolor readout" . | Sensors and Actuators B: Chemical 418 (2024) . |
| APA | Zheng, Zhenjie , Zhan, Linxiu , Wang, Liang , Deng, Ye , Lin, Yue , Luo, Fang et al. Aluminium-copper-mesoporous silica molecular sieve-enabled dual-signal point-of-care aptasensor with integrated temperature and multicolor readout . | Sensors and Actuators B: Chemical , 2024 , 418 . |
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Unexpected drug-drug interactions (DDIs) are important issues for both pharmaceutical research and clinical applications due to the high risk of causing severe adverse drug reactions or drug withdrawals. Many deep learning models have achieved high performance in DDI prediction, but model interpretability to reveal the underlying causes of DDIs has not been extensively explored. Here we propose MeTDDI-a deep learning framework with local-global self-attention and co-attention to learn motif-based graphs for DDI prediction. MeTDDI achieved competitive performance compared with state-of-the-art models. Regarding interpretability, we conducted extensive assessments on 73 drugs with 13,786 DDIs and MeTDDI can precisely explain the structural mechanisms for 5,602 DDIs involving 58 drugs. Besides, MeTDDI shows potential to explain complex DDI mechanisms and mitigate DDI risks. To summarize, MeTDDI provides a new perspective on exploring DDI mechanisms, which will benefit both drug discovery and polypharmacy for safer therapies for patients. A transformer-based approach that predicts drug-drug interactions in polypharmacy has been shown, which also identifies perpetrator drugs and the chemical mechanisms causing the interactions. The method could facilitate high-throughput optimization of drug combinations and mitigate adverse drug-drug interaction risks.
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| GB/T 7714 | Zhong, Yi , Li, Gaozheng , Yang, Ji et al. Learning motif-based graphs for drug-drug interaction prediction via local-global self-attention [J]. | NATURE MACHINE INTELLIGENCE , 2024 , 6 (9) . |
| MLA | Zhong, Yi et al. "Learning motif-based graphs for drug-drug interaction prediction via local-global self-attention" . | NATURE MACHINE INTELLIGENCE 6 . 9 (2024) . |
| APA | Zhong, Yi , Li, Gaozheng , Yang, Ji , Zheng, Houbing , Yu, Yongqiang , Zhang, Jiheng et al. Learning motif-based graphs for drug-drug interaction prediction via local-global self-attention . | NATURE MACHINE INTELLIGENCE , 2024 , 6 (9) . |
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Abstract ：
Dual-signal point-of-care testing (POCT) method relying on multicolor changes have demonstrated a promising improvement in performance. In this work, we have developed a highly sensitive and rapid POCT method for detecting aflatoxin B1 (AFB 1 ), utilizing a dual-signal readout mode based on temperature and multicolor changes. A synthetic enzyme mimics, Al-Cu-Santa Barbara Amorphous material (Al-Cu-SBA), has been used to enable the dual-signal changes of gold nanobipyramids (Au NBPs) for the first time. Specifically, the aptamer was immobilized on magnetic beads, facilitating hybridization with complementary strands functionalized with AlCu-SBA and hence forming double-stranded DNA. Upon introducing AFB 1 into the system, it bound to the aptamer chain, resulting in the release of Al-Cu-SBA into solution. The liberated Al-Cu-SBA was subsequently collected and used to oxidize 3, 3 ' , 5, 5 '-tetramethylbenzidine (TMB). The oxidized TMB was used to etch Au NBPs, inducing significant color changes. Meanwhile, by leveraging the photothermal properties of Au NBPs, we observed a temperature difference generated upon exposure to infrared laser irradiation. This method exhibited a linear range from 0.5 mu g & sdot; mL- 1 to 100 mu g & sdot; mL- 1 , with a detection limit of 0.167 mu g & sdot; mL- 1 . The method ' s applicability was extended to successfully detect AFB 1 in both peanut oil and milk samples. Given the application of enzyme mimics and the dual-signal readout integrating temperature and multicolor changes, our study successfully overcomes the limitations inherent in traditional biological enzyme-based methods and the conventional single-signal readout approach. Additionally, it surpasses the limitations associated with dual-signal readout systems that rely solely on monochromatic colorimetric analysis.
Keyword ：
Aflatoxin B1 Aflatoxin B1 Al -Cu -Santa Barbara Amorphous Al -Cu -Santa Barbara Amorphous Dual -signal readout Dual -signal readout Gold nanobipyramids Gold nanobipyramids Point -of -care testing Point -of -care testing
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| GB/T 7714 | Zheng, Zhenjie , Zhan, Linxiu , Wang, Liang et al. Aluminium-copper-mesoporous silica molecular sieve-enabled dual-signal point-of-care aptasensor with integrated temperature and multicolor readout [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 418 . |
| MLA | Zheng, Zhenjie et al. "Aluminium-copper-mesoporous silica molecular sieve-enabled dual-signal point-of-care aptasensor with integrated temperature and multicolor readout" . | SENSORS AND ACTUATORS B-CHEMICAL 418 (2024) . |
| APA | Zheng, Zhenjie , Zhan, Linxiu , Wang, Liang , Deng, Ye , Lin, Yue , Luo, Fang et al. Aluminium-copper-mesoporous silica molecular sieve-enabled dual-signal point-of-care aptasensor with integrated temperature and multicolor readout . | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 418 . |
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Halide perovskites have emerged as a highly promising class of photoelectric materials. However, the application of lead-based perovskites has been hindered by their toxicity and relatively weak stability. In this work, a composite material comprising a lead-free perovskite cesium copper iodide (CsCu2I3) nanocrystal and a metal-organic framework (MOF-801) has been synthesized through an in situ growth approach. The resulting composite material, denoted as CsCu2I3/MOF-801, demonstrates outstanding stability and exceptional optoelectronic characteristics. MOF-801 may serve a dual role by acting as a protective barrier between CsCu2I3 nanocrystals and the external environment, as well as promoting the efficient transfer of photogenerated charge carriers, thereby mitigating their recombination. Consequently, CsCu2I3/MOF-801 demonstrates its utility by providing both stability and a notably high initial photocurrent. Leveraging the inherent reactivity between H2S and the composite material, which results in the formation of Cu2S and structural alteration, an exceptionally sensitive photoelectrochemical sensor for H2S detection has been designed. This sensor exhibits a linear detection range spanning from 0.005 to 100 mu M with a remarkable detection limit of 1.67 nM, rendering it highly suitable for precise quantification of H2S in rat brains. This eco-friendly sensor significantly broadens the application horizon of perovskite materials and lays a robust foundation for their future commercialization.
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| GB/T 7714 | Mao, Mengfan , Zu, Yexin , Zhang, Yating et al. Photoelectrochemical Sensor for H2S Based on a Lead-Free Perovskite/Metal-Organic Framework Composite [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (10) : 4290-4298 . |
| MLA | Mao, Mengfan et al. "Photoelectrochemical Sensor for H2S Based on a Lead-Free Perovskite/Metal-Organic Framework Composite" . | ANALYTICAL CHEMISTRY 96 . 10 (2024) : 4290-4298 . |
| APA | Mao, Mengfan , Zu, Yexin , Zhang, Yating , Qiu, Yongzhen , Lin, Yue , Luo, Fang et al. Photoelectrochemical Sensor for H2S Based on a Lead-Free Perovskite/Metal-Organic Framework Composite . | ANALYTICAL CHEMISTRY , 2024 , 96 (10) , 4290-4298 . |
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Hydrogel dressings capable of infection monitoring and precise treatment administration show promise for advanced wound care. Existing methods involve embedd ingorganic dyes or flexible electronics into preformed hydrogels, which raise safety issues and adaptability challenges. In this study, an injectable hydrogel based smart wound dressing is developed by integrating food-derived anthocyanidin as a visual pH probe for infection monitoring and poly(L-lactic acid) microcapsules as ultrasound-responsive delivery systems for antibiotics into a poly(ethylene glycol) hydrogel. This straightforwardly prepared hydrogel dressing maintains its favorable properties for wound repair, including porous morphology and excellent biocompatibility. In vitro experiments demonstrated that the hydrogel enabled visual assessment of pH within the range of 5 similar to 9.Meanwhile, the release of antibiotics could be triggered and controlled by ultrasound. In vivo evaluations using infected wounds and diabetic wounds revealed that the wound dressing effectively detected wound infection by monitoring pH levels and achieved antibacterial effects through ultrasound-triggered drug release. This led to significantly enhanced wound healing, as validated by histological analysis and the measurement of inflammatory cytokine levels. This injectable hydrogel-based smart wound dressing holds great potential for use in clinical settings to inform timely and precise clinical intervention and in community to improve wound care management. The study presents an injectable hydrogel dressing with flexibility to fit irregularly shaped wounds and excellent biocompatibility for visual monitoring of infection and on-demand treatment. It utilizes food-derived anthocyanidin as a pH probe and poly(L-lactic acid) microcapsules for ultrasound-responsive drug delivery. In diabetic wounds, the dressing detects infections through pH monitoring and enhances healing via ultrasound-triggered drug release.image
Keyword ：
chronic wounds chronic wounds hydrogels hydrogels on-demand treatment on-demand treatment pH detection pH detection ultrasound responsive ultrasound responsive wound monitoring wound monitoring
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| GB/T 7714 | Huang, Da , Du, Jiahao , Luo, Fang et al. Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (9) . |
| MLA | Huang, Da et al. "Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds" . | ADVANCED HEALTHCARE MATERIALS 13 . 9 (2024) . |
| APA | Huang, Da , Du, Jiahao , Luo, Fang , He, Gang , Zou, Minglang , Wang, Yongming et al. Injectable Hydrogels with Integrated Ph Probes and Ultrasound-Responsive Microcapsules as Smart Wound Dressings for Visual Monitoring and On-Demand Treatment of Chronic Wounds . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (9) . |
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Curcumin (CUR) is a natural polyphenol that holds promise for treating ulcerative colitis (UC), yet oral administration of CUR exhibits limited bioavailability and existing formulations for oral delivery of CUR often suffer from unsatisfactory loading capacity. This study presents hydroxyethyl starch-curcumin microspheres (HCMSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19.91 %), for combination therapy of UC. The microspheres were successfully engineered, retaining the antioxidative and anti-inflammatory activities of parental CUR and demonstrating excellent biocompatibility and controlled release properties, notably triggered by alpha-amylase, facilitating targeted drug delivery to inflamed sites. In a mouse UC model induced by dextran sulfate sodium, the microspheres effectively accumulated in inflamed colons and both HC-MSs and DHC-MSs exhibited superior therapeutic efficacy in alleviating UC symptoms compared to free DEX. Moreover, mechanistic exploration uncovered the multifaceted therapeutic mechanisms of these formulations, encompassing anti-inflammatory actions, mitigation of spleen enlargement, and modulation of gut microbiota composition. These findings underscore the potential of HC-MSs and DHC-MSs as promising formulations for UC, with implications for advancing treatment modalities for various inflammatory bowel disorders.
Keyword ：
Anti-inflammatory Anti-inflammatory Curcumin Curcumin Gut microbiota Gut microbiota Microspheres Microspheres Oral delivery Oral delivery Ulcerative colitis Ulcerative colitis
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| GB/T 7714 | Huang, Da , Wang, Yongming , Xu, Chenlan et al. Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 266 . |
| MLA | Huang, Da et al. "Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 266 (2024) . |
| APA | Huang, Da , Wang, Yongming , Xu, Chenlan , Zou, Minglang , Ming, Yangcan , Luo, Fang et al. Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 266 . |
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The increasing prevalence of antibiotic resistance in Cutibacterium acnes (C. acnes) requires the search for alternative therapeutic strategies. Antimicrobial peptides (AMPs) offer a promising avenue for the development of new treatments targeting C. acnes. In this study, to design peptides with the specific inhibitory activity against C. acnes, we employed a deep learning pipeline with generators and classifiers, using transfer learning and pretrained protein embeddings, trained on publicly available data. To enhance the training data specific to C. acnes inhibition, we constructed a phylogenetic tree. A panel of 42 novel generated linear peptides was then synthesized and experimentally evaluated for their antimicrobial selectivity and activity. Five of them demonstrated their high potency and selectivity against C. acnes with MIC of 2-4 mu g/mL. Our findings highlight the potential of these designed peptides as promising candidates for anti-acne therapeutics and demonstrate the power of computational approaches for the rational design of targeted antimicrobial peptides.
Keyword ：
Antimicrobial peptides Antimicrobial peptides Cutibacterium acnes Cutibacterium acnes Deep learning Deep learning Pretrained protein language embedding Pretrained protein language embedding Transfer learning Transfer learning
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| GB/T 7714 | Dong, Qichang , Wang, Shaohua , Miao, Ying et al. Novel antimicrobial peptides against Cutibacterium acnes designed by deep learning [J]. | SCIENTIFIC REPORTS , 2024 , 14 (1) . |
| MLA | Dong, Qichang et al. "Novel antimicrobial peptides against Cutibacterium acnes designed by deep learning" . | SCIENTIFIC REPORTS 14 . 1 (2024) . |
| APA | Dong, Qichang , Wang, Shaohua , Miao, Ying , Luo, Heng , Weng, Zuquan , Yu, Lun . Novel antimicrobial peptides against Cutibacterium acnes designed by deep learning . | SCIENTIFIC REPORTS , 2024 , 14 (1) . |
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